Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis
Shunsuke Miura
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Yoshihide Asano
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Correspondence: Yoshihide Asano, M.D., Ph.D., or Takafumi Kadono, M.D., Ph.D., Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Email: [email protected] or [email protected]
Search for more papers by this authorRyosuke Saigusa
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakashi Yamashita
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakashi Taniguchi
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakehiro Takahashi
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorYohei Ichimura
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTetsuo Toyama
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorZenshiro Tamaki
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorYayoi Tada
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorMakoto Sugaya
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorShinichi Sato
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Takafumi Kadono
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Correspondence: Yoshihide Asano, M.D., Ph.D., or Takafumi Kadono, M.D., Ph.D., Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Email: [email protected] or [email protected]
Search for more papers by this authorShunsuke Miura
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Yoshihide Asano
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Correspondence: Yoshihide Asano, M.D., Ph.D., or Takafumi Kadono, M.D., Ph.D., Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Email: [email protected] or [email protected]
Search for more papers by this authorRyosuke Saigusa
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakashi Yamashita
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakashi Taniguchi
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTakehiro Takahashi
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorYohei Ichimura
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorTetsuo Toyama
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorZenshiro Tamaki
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorYayoi Tada
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorMakoto Sugaya
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorShinichi Sato
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Takafumi Kadono
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Correspondence: Yoshihide Asano, M.D., Ph.D., or Takafumi Kadono, M.D., Ph.D., Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Email: [email protected] or [email protected]
Search for more papers by this authorAbstract
Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis (SSc). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SSc and control subjects, serum vaspin levels were significantly decreased in SSc patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.
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