Efficacy of Oral Psyllium in Pediatric Irritable Bowel Syndrome
A Double-Blind Randomized Control Trial
Corresponding Author
Miranda A.L. van Tilburg PhD
University of North Carolina, Chapel Hill, NC
University of Washington, Seattle, WA
Marshall University, Huntington, WV
Cape Fear Valley Medical Center, Fayetteville, NC
Address correspondence and reprint requests to Miranda A.L. van Tilburg, PhD, University of North Carolina, Chapel Hill, NC (e-mail: [email protected]).Search for more papers by this authorBonney Reed PhD
Emory University/Children’s Healthcare of Atlanta, Atlanta, GA
Search for more papers by this authorMarc Benninga MD, PhD
Emma Children’s Hospital/Amsterdam University Medical Centers, Amsterdam, Netherlands
Search for more papers by this authorAshish Chogle MD
Children’s Hospital of Orange County, Orange, CA
Search for more papers by this authorBruno P. Chumpitazi MD, MPH
Baylor College of Medicine/Texas Children’s Hospital, Houston, TX
Search for more papers by this authorCarlo DiLorenzo MD
Nationwide Children’s Hospital, Columbus, OH
Search for more papers by this authorShaman Rajindrajith MBBS, FRCPCH, MD, PhD
University of Colombo, Colombo, Sri Lanka
Search for more papers by this authorRobert J. Shulman MD
Baylor College of Medicine/Texas Children’s Hospital, Houston, TX
Search for more papers by this authorAnnamaria Staiano MD
University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorNikhil Thapar MRCP, FRCPCH, FRACP, PhD
Queensland Children’s Hospital/University of Queensland/Queensland University of Technology, Brisbane, Australia
Search for more papers by this authorCarlos A. Velasco Benitez MD, MSc, PhD
Universidad del Valle: Cali, Valle, Colombia
Search for more papers by this authorArine Vlieger MD, PhD
St. Antonius Hospital, Utrecht, the Netherlands
Search for more papers by this authorCorresponding Author
Miranda A.L. van Tilburg PhD
University of North Carolina, Chapel Hill, NC
University of Washington, Seattle, WA
Marshall University, Huntington, WV
Cape Fear Valley Medical Center, Fayetteville, NC
Address correspondence and reprint requests to Miranda A.L. van Tilburg, PhD, University of North Carolina, Chapel Hill, NC (e-mail: [email protected]).Search for more papers by this authorBonney Reed PhD
Emory University/Children’s Healthcare of Atlanta, Atlanta, GA
Search for more papers by this authorMarc Benninga MD, PhD
Emma Children’s Hospital/Amsterdam University Medical Centers, Amsterdam, Netherlands
Search for more papers by this authorAshish Chogle MD
Children’s Hospital of Orange County, Orange, CA
Search for more papers by this authorBruno P. Chumpitazi MD, MPH
Baylor College of Medicine/Texas Children’s Hospital, Houston, TX
Search for more papers by this authorCarlo DiLorenzo MD
Nationwide Children’s Hospital, Columbus, OH
Search for more papers by this authorShaman Rajindrajith MBBS, FRCPCH, MD, PhD
University of Colombo, Colombo, Sri Lanka
Search for more papers by this authorRobert J. Shulman MD
Baylor College of Medicine/Texas Children’s Hospital, Houston, TX
Search for more papers by this authorAnnamaria Staiano MD
University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorNikhil Thapar MRCP, FRCPCH, FRACP, PhD
Queensland Children’s Hospital/University of Queensland/Queensland University of Technology, Brisbane, Australia
Search for more papers by this authorCarlos A. Velasco Benitez MD, MSc, PhD
Universidad del Valle: Cali, Valle, Colombia
Search for more papers by this authorArine Vlieger MD, PhD
St. Antonius Hospital, Utrecht, the Netherlands
Search for more papers by this author
REFERENCES
- 1.Menon J, Thapa BR, Kumari R, Puttaiah Kadyada S, Rana S, Lal SB. Efficacy of oral psyllium in pediatric irritable bowel syndrome: a double-blind randomized control trial. J Pediatr Gastroenterol Nutr 2023; 76: 14–9. doi:10.1097/MPG.0000000000003622.
- 2.Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 1997; 11: 395–402.
- 3.Saps M, Youssef N, Miranda A, et al. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology 2009; 137: 1261–9. doi:10.1053/j.gastro.2009.06.060.
- 4.Vlieger AM, Menko-Frankenhuis C, Wolfkamp SC, Tromp E, Benninga MA. Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial. Gastroenterology 2007; 133: 1430–6. doi:10.1053/j.gastro.2007.08.072.
- 5.Levy RL, Langer SL, van Tilburg MA, et al. Brief telephone-delivered cognitive behavioral therapy targeted to parents of children with functional abdominal pain: a randomized controlled trial. Pain 2017; 158: 618–28. doi:10.1097/j.pain.0000000000000800.
- 6.Shulman RJ, Hollister EB, Cain K, et al. Psyllium fiber reduces abdominal pain in children with irritable bowel syndrome in a randomized, double-blind trial. Clin Gastroenterol Hepatol 2017; 15: 712–719.e4. doi:10.1016/j.cgh.2016.03.045.
- 7.Zeevenhooven J, Rexwinkel R, Van Berge Henegouwen VWA, et al. A core outcome set for clinical trials in pediatric functional abdominal pain disorders. J Pediatr 2020; 221: 115–122.e5. doi:10.1016/j.jpeds.2020.02.032.
- 8.Saps M, van Tilburg MA, Lavigne JV, et al. Recommendations for pharmacological clinical trials in children with irritable bowel syndrome: the Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil 2016; 28: 1619–31. doi:10.1111/nmo.12896.
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