Evaluation of Risk for Thromboembolic Events in Pediatric Inflammatory Bowel Disease
Correction(s) for this article
-
Evaluation of Risk for Thromboembolic Events in Pediatric Inflammatory Bowel Disease
- Volume 77Issue 2Journal of Pediatric Gastroenterology and Nutrition
- pages: e53-e53
- First Published online: August 1, 2023
Corresponding Author
Anna Dilillo
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Address correspondence and reprint requests to Anna Dilillo, MD, PhD, Maternal and Child Health, Department, Santa Maria Goretti Hospital, Sapienza—University of Rome, Polo Pontino, via Antonio Canova, 04100 Latina, Italy (e-mail: [email protected], [email protected]).Search for more papers by this authorEmanuela Del Giudice
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSalvatore Cucchiara
Maternal Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy
Search for more papers by this authorFranca Viola
Maternal Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy
Search for more papers by this authorSaverio Maliardo
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSara Isoldi
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorDonatella lorfida
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSilvia Bloise
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorAlessia Marcellino
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorVanessa Martucci
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorMariateresa Sanseviero
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorEnrica De Luca
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorCarmela Protano
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorDaniela Marotta
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFlavia Ventriglia
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorRiccardo Lubrano
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorCorresponding Author
Anna Dilillo
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Address correspondence and reprint requests to Anna Dilillo, MD, PhD, Maternal and Child Health, Department, Santa Maria Goretti Hospital, Sapienza—University of Rome, Polo Pontino, via Antonio Canova, 04100 Latina, Italy (e-mail: [email protected], [email protected]).Search for more papers by this authorEmanuela Del Giudice
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSalvatore Cucchiara
Maternal Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy
Search for more papers by this authorFranca Viola
Maternal Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy
Search for more papers by this authorSaverio Maliardo
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSara Isoldi
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorDonatella lorfida
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorSilvia Bloise
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorAlessia Marcellino
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorVanessa Martucci
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorMariateresa Sanseviero
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorEnrica De Luca
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorCarmela Protano
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorDaniela Marotta
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
Search for more papers by this authorFlavia Ventriglia
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorRiccardo Lubrano
Pediatric and Neonatology Unit, Maternal and Child Department, Sapienza University of Rome, Polo Pontino, Latina
Search for more papers by this authorDrs Anna Dilillo and Emanuela Del Giudice contributed equally to this study.
Disclosures: No honorarium, grant, or other form of payment was given to anyone to write and to produce the manuscript.
The authors report no conflict of interest.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).
ABSTRACT
Objectives:
The occurrence of thrombotic events in adult patients with inflammatory bowel disease (IBD) is linked to multiple interactions between hereditary and acquired risk factors. There are few published data concerning children with iBD. The aim of this study was to investigate the presence of thromboembolic risk factors also in children with iBD.
Methods:
We enrolled three groups of children: one with Crohn disease (cD), one with ulcerative colitis (Uc), and a control group of healthy subjects. For all the participants the potential thromboembolic risk was evaluated clinically and with laboratory tests.
Results:
We studied: 30 children (25.6%) with CD, 28 (23.9%) with UC, and 59 (50.4%) healthy control subjects. Regarding Pediatric Crohn Disease Activity Index, no significant differences between thromboembolic risk factors and disease activity were detected. Instead, in the patients with UC, stratified with the Pediatric Ulcerative Colitis Activity Index, there was a statistically significant difference in serum fibrinogen levels between patients with mild and moderate/severe disease [3.8 (3.2–4.5) g/L vs 5.7 (4.8–6.2) g/L, P < 0.0032]. serum homocysteine levels were lower in healthy controls than in CD (P = 0.176) and UC (P = 0.026). An increased level ofhomocysteine in UC with a homozygous mutation in the methylene tetrahydrofolate reductase C677T gene was also observed.
Conclusions:
Our study showed that children with IBD have clinical features, acquired and congenital factors that can increase thrombotic risk, similarly to adults.
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