Sustainable Positive Response to Sirolimus in Juvenile Polyposis of Infancy
Muriel Quaranta
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorNolwenn Laborde
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France
Search for more papers by this authorAudrey Ferrand
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorMarie Danjoux
Département d’Anatomie et de Cytologie pathologiques, IUCT Oncopole, Toulouse, France
Search for more papers by this authorNathalie Vergnolle
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorFrédérick Barreau
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorClaire Racaud-Sultan
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorEmmanuel Mas
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France
Search for more papers by this authorMuriel Quaranta
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorNolwenn Laborde
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France
Search for more papers by this authorAudrey Ferrand
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorMarie Danjoux
Département d’Anatomie et de Cytologie pathologiques, IUCT Oncopole, Toulouse, France
Search for more papers by this authorNathalie Vergnolle
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorFrédérick Barreau
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorClaire Racaud-Sultan
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Search for more papers by this authorEmmanuel Mas
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France
Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France
Search for more papers by this author
REFERENCES
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- 2.Menko FH, Kneepkens CM, de Leeuw N, et al. Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes. Clin Genet 2008; 74: 145–154.
- 3.He XC, Zhang J, Tong WG, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 2004; 36: 1117–1121.
- 4.Marsh V, Winton DJ, Williams GT, et al. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet 2008; 40: 1436–1444.
- 5.Fujishita T, Aoki K, Lane HA, et al. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 2008; 105: 13544–13549.
- 6.Hardiman KM, Liu J, Feng Y, et al. Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model. PLoS One 2014; 9: e96023.
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