Fecal Transplant for Recurrent Clostridium difficile Infection in Children With and Without Inflammatory Bowel Disease
Corresponding Author
George H. Russell
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Address correspondence and reprint requests to George H. Russell, MD, MS, Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, 175 Cambridge St, CPZ-S5, Boston, MA 02114 (e-mail: [email protected]).Search for more papers by this authorJess L. Kaplan
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorIlan Youngster
Division of Pediatric Infectious Diseases, Children's Hospital Boston, Boston, MA
Search for more papers by this authorMariah Baril-Dore
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorLili Schindelar
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorElizabeth Hohmann
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA
Search for more papers by this authorHarland S. Winter
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorCorresponding Author
George H. Russell
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Address correspondence and reprint requests to George H. Russell, MD, MS, Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, 175 Cambridge St, CPZ-S5, Boston, MA 02114 (e-mail: [email protected]).Search for more papers by this authorJess L. Kaplan
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorIlan Youngster
Division of Pediatric Infectious Diseases, Children's Hospital Boston, Boston, MA
Search for more papers by this authorMariah Baril-Dore
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorLili Schindelar
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorElizabeth Hohmann
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA
Search for more papers by this authorHarland S. Winter
Division of Pediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, MA
Search for more papers by this authorThe authors report no conflicts of interest.
ABSTRACT
Ten children at our institution received single-infusion fecal microbiome transplant (FMT) using healthy, related screened donor stool to treat recurrent Clostridium difficile infection (RCDI) via nasogastric tube (2 patients) or colonoscopic delivery. Nine of the 10 (90%) children had resolution of their symptoms after a single-infusion FMT with follow-up of 1 month to 4 years. No concerning related adverse events were recognized during short- or long-term follow-up. Three of these children had concomitant inflammatory bowel disease and 2 of these 3 (66%) patients cleared RCDI with no clinical change in their underlying inflammatory bowel disease clinical activity as assessed by Physician's Global Assessment. All of the patients who had clinical improvement of gastrointestinal symptoms of RCDI while treated with antibiotics had lasting return of baseline health after FMT.
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