Journal of Pediatric Gastroenterology and Nutrition

Original Article: Hepatologyand Nutrition

Seasonal Vitamin D Status of Healthy Schoolchildren and Predictors of Low Vitamin D Status

Corresponding Author

Gülay Karagüzel

[email protected]

Department of Pediatric Endocrinology, Karadeniz Technical University, Trabzon, Turkey

Address correspondence and reprint requests to Gülay Karagüzel, MD, Department of Pediatric Endocrinology, School of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey (e-mail: [email protected]).Search for more papers by this author

Beril Dilber,

Beril Dilber

Department of Pediatrics, School of Medicine, Karadeniz Technical University, Trabzon, Turkey

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Gamze Çan,

Gamze Çan

Department of Public Health, Karadeniz Technical University, Trabzon, Turkey

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Ayşenur Ökten,

Ayşenur Ökten

Department of Pediatric Endocrinology, Karadeniz Technical University, Trabzon, Turkey

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Orhan Değer,

Orhan Değer

Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey

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Michael F. Holick,

Michael F. Holick

Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA

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Gülay Karagüzel,

Corresponding Author

Gülay Karagüzel

[email protected]

Department of Pediatric Endocrinology, Karadeniz Technical University, Trabzon, Turkey

Beril Dilber,

Beril Dilber

Department of Pediatrics, School of Medicine, Karadeniz Technical University, Trabzon, Turkey

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Gamze Çan,

Gamze Çan

Department of Public Health, Karadeniz Technical University, Trabzon, Turkey

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Ayşenur Ökten,

Ayşenur Ökten

Department of Pediatric Endocrinology, Karadeniz Technical University, Trabzon, Turkey

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Orhan Değer,

Orhan Değer

Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey

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Michael F. Holick,

Michael F. Holick

Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA

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First published: 01 May 2014

https://doi.org/10.1097/MPG.0000000000000274

Citations: 44

This study was supported by Karadeniz Technical University Research Project Unit under protocol no. 2009.114.003.09, and it was presented as a poster at ESPE 2012, Leipzeg, Germany.

The authors report no conflict of interest.

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ABSTRACT

Objectives:

The aim of the study was to assess seasonal prevalence of vitamin D deficiency according to sex and to determine the relations between serum levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) and sociodemographic characteristics in otherwise healthy schoolchildren during spring and autumn.

Methods:

In a cross-sectional study, 746 healthy students aged between 11 and 18 years were recruited during spring (n = 375) and autumn (n = 371). Sociodemographic data were collected by a questionnaire. Serum 25(OH)D, PTH, calcium, phosphate, and alkaline phosphatase were measured. Serum 25(OH)D levels were categorized as <50 nmol/L (vitamin D deficiency) and <25 nmol/L (severe deficiency).

Results:

Mean ± standard deviation 25(OH)D levels were 22.3 ± 10.5 nmol/L in girls and 28.5 ± 17.0 nmol/L in boys during spring (P < 0.001) and 36.5 ± 20.3 nmol/L in girls and 45.0 ± 18.5 nmol/L in boys during autumn (P < 0.001). The prevalence of vitamin D deficiency was 93% during spring and 71% during autumn. There was a negative correlation between 25(OH)D and PTH levels (P < 0.01). We determined a cutoff point of serum 25(OH)D in which the mean serum PTH concentration began to increase as 35.8 nmol/L (P < 0.0001). The age, sex, and calcium level were found to be independent predictors for vitamin D deficiency.

Conclusions:

Vitamin D deficiency is prevalent among healthy schoolchildren. It is noteworthy that 25(OH)D levels were significantly lower in girls and during autumn. We recommend vitamin D supplementation for children in addition to more time spent for outdoor activities for sensible sunlight exposure.

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Volume58, Issue5

May 2014

Pages 654-660

Seasonal Vitamin D Status of Healthy Schoolchildren and Predictors of Low Vitamin D Status

ABSTRACT

Objectives:

Methods:

Results:

Conclusions:

REFERENCES

Citing Literature

References

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Seasonal Vitamin D Status of Healthy Schoolchildren and Predictors of Low Vitamin D Status

ABSTRACT

Objectives:

Methods:

Results:

Conclusions:

REFERENCES

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