Very Low Birth Weight Infants as a Model to Study Genetic Influences on Neonatal Weight Gain
Corresponding Author
Juliane Spiegler
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Address correspondence and reprint requests to Juliane Spiegler, MD, Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany (e-mail: [email protected]).Search for more papers by this authorEvelyn Kattner
Department of Olgahospital, Stuttgart, Germany
Department of Kinderklinik auf der Bult, Hannover, Germany
Search for more papers by this authorMatthias Vochem
Department of Olgahospital, Stuttgart, Germany
Department of Kinderklinik auf der Bult, Hannover, Germany
Search for more papers by this authorHelmuth Küster
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, Greifswald University, Greifswald, Germany
Search for more papers by this authorJens Möller
Department of Olgahospital, Stuttgart, Germany
Children's Hospital Saarbrücken, Germany
Search for more papers by this authorDirk Müller
Department of Olgahospital, Stuttgart, Germany
Children's Hospital, Kassel, Germany
Search for more papers by this authorAngela Kribs
Department of Olgahospital, Stuttgart, Germany
Children's Hospital, University of Cologne, Germany
Search for more papers by this authorHugo Segerer
Department of Olgahospital, Stuttgart, Germany
Kinderklinik St. Hedwig, Regensburg, Germany
Search for more papers by this authorChristian Wieg
Department of Olgahospital, Stuttgart, Germany
Children's Hospital Aschaffenburg, Germany
Search for more papers by this authorWerner Nikischin
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Kiel, Germany
Search for more papers by this authorAxel von der Wense
Department of Olgahospital, Stuttgart, Germany
Altonaer Kinderkrankenhaus, Hamburg, Germany
Search for more papers by this authorCorinna Gebauer
Department of Olgahospital, Stuttgart, Germany
Universitätskinderklinik Leipzig, Germany
Search for more papers by this authorEgbert Herting
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Search for more papers by this authorWolfgang Göpel
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Search for more papers by this authorCorresponding Author
Juliane Spiegler
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Address correspondence and reprint requests to Juliane Spiegler, MD, Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany (e-mail: [email protected]).Search for more papers by this authorEvelyn Kattner
Department of Olgahospital, Stuttgart, Germany
Department of Kinderklinik auf der Bult, Hannover, Germany
Search for more papers by this authorMatthias Vochem
Department of Olgahospital, Stuttgart, Germany
Department of Kinderklinik auf der Bult, Hannover, Germany
Search for more papers by this authorHelmuth Küster
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, Greifswald University, Greifswald, Germany
Search for more papers by this authorJens Möller
Department of Olgahospital, Stuttgart, Germany
Children's Hospital Saarbrücken, Germany
Search for more papers by this authorDirk Müller
Department of Olgahospital, Stuttgart, Germany
Children's Hospital, Kassel, Germany
Search for more papers by this authorAngela Kribs
Department of Olgahospital, Stuttgart, Germany
Children's Hospital, University of Cologne, Germany
Search for more papers by this authorHugo Segerer
Department of Olgahospital, Stuttgart, Germany
Kinderklinik St. Hedwig, Regensburg, Germany
Search for more papers by this authorChristian Wieg
Department of Olgahospital, Stuttgart, Germany
Children's Hospital Aschaffenburg, Germany
Search for more papers by this authorWerner Nikischin
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Kiel, Germany
Search for more papers by this authorAxel von der Wense
Department of Olgahospital, Stuttgart, Germany
Altonaer Kinderkrankenhaus, Hamburg, Germany
Search for more papers by this authorCorinna Gebauer
Department of Olgahospital, Stuttgart, Germany
Universitätskinderklinik Leipzig, Germany
Search for more papers by this authorEgbert Herting
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Search for more papers by this authorWolfgang Göpel
Department of Olgahospital, Stuttgart, Germany
Department of Pediatrics, University of Lübeck, Germany
Search for more papers by this authorThe authors report no conflicts of interest.
ABSTRACT
In a cohort of 829 preterm infants (birth weight below 1500 g) we identified 13 monozygotic, 10 same-sex dizygotic, and 12 same-sex matched singleton pairs. The difference in daily weight gain within pairs was significantly lower in monozygotic twins compared with dizygotic twins or matched singleton pairs. Our data support a strong genetic influence on postnatal growth in preterm infants. Therefore, weight gain of preterm infants may be an interesting model to study polymorphic variants of genes regulating neonatal resorption, metabolism, or energy expenditure, and their influence on weight gain in preterm infants.
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