S292: NIRMATRELVIR/RITONAVIR IN COVID-19 PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES: A REPORT FROMTHE EPICOVIDEHA REGISTRY
Jon Salmanton-García
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorFrancesco Marchesi
HEMatology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
Search for more papers by this authorMaria Gomes Da Silva
Portuguese Institute of Oncology, Lisbon, Portugal
Search for more papers by this authorJulio Dávila-Valls
Hospital Nuestra Señora de Sonsoles, Ávila, Spain
Search for more papers by this authorYavuz M. Bilgin
Department of Internal Medicine, ADRZ, Goes, Netherlands
Search for more papers by this authorAndreas Glenthøj
Department of HEMatology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorIker Falces-Romero
“La Paz University Hospital, Madrid, Spain CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain
Search for more papers by this authorJaap Van Doesum
University Medical Center Groningen, Groningen, Netherlands
Search for more papers by this authorJorge Labrador
Department of HEMatology, Research Unit, Hospital Universitario de Burgos, Burgos, Spain Facultad de Ciencias de la Salud, Universidad Isabel I, Burgos, Spain
Search for more papers by this authorCaterina Buquicchio
Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta, Italy
Search for more papers by this authorShaimaa EL-Ashwah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorVerena Petzer
Department of HEMatology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
Search for more papers by this authorJens VAN Praet
Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium
Search for more papers by this authorMartin Schönlein
Department of Oncology, HEMatology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Search for more papers by this authorMichelina Dargenio
HEMatology and Stem Cell transplan Unit, Vito Fazzi, Lecce
Search for more papers by this authorGustavo-Adolfo Méndez
Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Argentina
Search for more papers by this authorFederico Itri
San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy
Search for more papers by this authorAntonio Giordano
HEMatology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy
Search for more papers by this authorLaszlo Imre Pinczes
Division of HEMatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorIldefonso Espigado
Department of HEMatology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
Search for more papers by this authorZlate Stojanoski
University Clinic of HEMatology, Skopje, North Macedonia
Search for more papers by this authorAlberto Lopez-Garcia
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorLucia Prezioso
Hospital University of Parma - HEMatology and Bone Marrow Unit, Parma, Italy
Search for more papers by this authorOzren Jaksic
Department of HEMatology, University Hospital Dubrava, Zagreb, Croatia
Search for more papers by this authorNicola Stefano Fracchiolla
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Search for more papers by this authorTomas Jose Gonzalez-Lopez
Department of HEMatology, Hospital Universitario de Burgos, Burgos, Spain
Search for more papers by this authorNatasa Čolović
University Clinical Center Serbia, Medical Faculty University Belgrade, Belgrade, Serbia
Search for more papers by this authorMario Delia
HEMatology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
Search for more papers by this authorBarbora Weinbergerová
Department of Internal Medicine - HEMatology and Oncology, Masaryk University Hospital Brno, Brno, Czech Republic
Search for more papers by this authorMonia Marchetti
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
Search for more papers by this authorJoyce Marques DE Almeida
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
Search for more papers by this authorCaroline Besson
Université Paris-Saclay, UVSQ, Inserm, Équipe “Exposome et Hérédité”, CESP, Villejuif, France
Centre Hospitalier de Versailles, Le Chesnay, France
Search for more papers by this authorMonika M. Biernat
Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
Search for more papers by this authorToni Valkovic
University Hospital Centre Rijeka, Rijeka, Croatia Croatian Cooperative Group for HEMatological Diseases (CROHEM) Faculty of Medicine and Faculty of Health Studies University of Rijeka, Rijeka, Croatia
Search for more papers by this authorTobias Lahmer
Medizinische Klinik II, Klinikum rechts der Isar, TU München, Munich, Germany
Search for more papers by this authorAnnarosa Cuccaro
HEMatology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, Livorno, Italy
Search for more papers by this authorIrati Ormazabal Velez
Complejo Hospitalario de Navarra, Iruña-Pamplona, Spain
Search for more papers by this authorJosip Batinic
University Hospital Centre Zagreb, Zagreb, Croatia School of Medicine University of Zagreb, Zagreb, Croatia
Search for more papers by this authorNoemí Fernández
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Search for more papers by this authorNick de Jonge
Amsterdam UMC, location VUmc, Amsterdam, Netherlands
Search for more papers by this authorCarlo Tascini
Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
Search for more papers by this authorAmalia N. Anastasopoulou
Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Search for more papers by this authorRémy Duléry
Service d’Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Inserm UMRs 938, Paris, France
Search for more papers by this authorMaria Ilaria DEL Principe
HEMatology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
Search for more papers by this authorGaëtan Plantefeve
Head ICU and CRC, Centre Hospitalier Victor DUPOUY, Argenteuil, France
Search for more papers by this authorMario Virgilio Papa
Azienda Ospedaliera Sant’Anna e San Sebastiano, Caserta, Italy
Search for more papers by this authorMarcio Nucci
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Search for more papers by this authorMoraima Carmen Jimenez Balarezo
Department of HEMatology, Vall d’Hebron Hospital Universitari, Experimental HEMatology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
Search for more papers by this authorAvinash Aujayeb
Northumbria Healthcare, Newcastle, United Kingdom
Search for more papers by this authorJose Angel Hernandez Rivas
Hospital Universitario Infanta Leonor, Madrid, Spain Departmento de Medicina, Universidad Complutense de Madrid, Madrid, Spain
Search for more papers by this authorMaria Merelli
Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
Search for more papers by this authorChiara Cattaneo
HEMatology Unit, ASST-Spedali Civili, Brescia, Italy
Search for more papers by this authorOla Blennow
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorAnna Nordlander
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorAlba Cabirta
Department of HEMatology, Vall d’Hebron Hospital Universitari, Experimental HEMatology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
Search for more papers by this authorGina Varricchio
Azienda Ospedaliera Sant’Anna e San Sebastiano, Caserta, Italy
Search for more papers by this authorMaria Vittoria Sacchi
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
Search for more papers by this authorRaul Cordoba
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorElena Arellano
Department of HEMatology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
Search for more papers by this authorStefanie Gräfe
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorDominik Wolf
Department of HEMatology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
Search for more papers by this authorZiad Emarah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorEmanuele Ammatuna
University Medical Center Groningen, Groningen, Netherlands
Search for more papers by this authorDitte Stampe Hersby
Department of HEMatology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorSonia Martín-Pérez
Hospital Nuestra Señora de Sonsoles, Ávila, Spain
Search for more papers by this authorRaquel Nunes Rodrigues
Portuguese Institute of Oncology, Lisbon, Portugal
Search for more papers by this authorLaman Rahimli
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorLivio Pagano
HEMatology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy
Search for more papers by this authorOliver A. Cornely
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany
German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
Search for more papers by this authorJon Salmanton-García
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorFrancesco Marchesi
HEMatology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
Search for more papers by this authorMaria Gomes Da Silva
Portuguese Institute of Oncology, Lisbon, Portugal
Search for more papers by this authorJulio Dávila-Valls
Hospital Nuestra Señora de Sonsoles, Ávila, Spain
Search for more papers by this authorYavuz M. Bilgin
Department of Internal Medicine, ADRZ, Goes, Netherlands
Search for more papers by this authorAndreas Glenthøj
Department of HEMatology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorIker Falces-Romero
“La Paz University Hospital, Madrid, Spain CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain
Search for more papers by this authorJaap Van Doesum
University Medical Center Groningen, Groningen, Netherlands
Search for more papers by this authorJorge Labrador
Department of HEMatology, Research Unit, Hospital Universitario de Burgos, Burgos, Spain Facultad de Ciencias de la Salud, Universidad Isabel I, Burgos, Spain
Search for more papers by this authorCaterina Buquicchio
Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta, Italy
Search for more papers by this authorShaimaa EL-Ashwah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorVerena Petzer
Department of HEMatology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
Search for more papers by this authorJens VAN Praet
Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium
Search for more papers by this authorMartin Schönlein
Department of Oncology, HEMatology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Search for more papers by this authorMichelina Dargenio
HEMatology and Stem Cell transplan Unit, Vito Fazzi, Lecce
Search for more papers by this authorGustavo-Adolfo Méndez
Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Argentina
Search for more papers by this authorFederico Itri
San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy
Search for more papers by this authorAntonio Giordano
HEMatology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy
Search for more papers by this authorLaszlo Imre Pinczes
Division of HEMatology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Search for more papers by this authorIldefonso Espigado
Department of HEMatology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
Search for more papers by this authorZlate Stojanoski
University Clinic of HEMatology, Skopje, North Macedonia
Search for more papers by this authorAlberto Lopez-Garcia
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorLucia Prezioso
Hospital University of Parma - HEMatology and Bone Marrow Unit, Parma, Italy
Search for more papers by this authorOzren Jaksic
Department of HEMatology, University Hospital Dubrava, Zagreb, Croatia
Search for more papers by this authorNicola Stefano Fracchiolla
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Search for more papers by this authorTomas Jose Gonzalez-Lopez
Department of HEMatology, Hospital Universitario de Burgos, Burgos, Spain
Search for more papers by this authorNatasa Čolović
University Clinical Center Serbia, Medical Faculty University Belgrade, Belgrade, Serbia
Search for more papers by this authorMario Delia
HEMatology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
Search for more papers by this authorBarbora Weinbergerová
Department of Internal Medicine - HEMatology and Oncology, Masaryk University Hospital Brno, Brno, Czech Republic
Search for more papers by this authorMonia Marchetti
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
Search for more papers by this authorJoyce Marques DE Almeida
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
Search for more papers by this authorCaroline Besson
Université Paris-Saclay, UVSQ, Inserm, Équipe “Exposome et Hérédité”, CESP, Villejuif, France
Centre Hospitalier de Versailles, Le Chesnay, France
Search for more papers by this authorMonika M. Biernat
Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
Search for more papers by this authorToni Valkovic
University Hospital Centre Rijeka, Rijeka, Croatia Croatian Cooperative Group for HEMatological Diseases (CROHEM) Faculty of Medicine and Faculty of Health Studies University of Rijeka, Rijeka, Croatia
Search for more papers by this authorTobias Lahmer
Medizinische Klinik II, Klinikum rechts der Isar, TU München, Munich, Germany
Search for more papers by this authorAnnarosa Cuccaro
HEMatology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, Livorno, Italy
Search for more papers by this authorIrati Ormazabal Velez
Complejo Hospitalario de Navarra, Iruña-Pamplona, Spain
Search for more papers by this authorJosip Batinic
University Hospital Centre Zagreb, Zagreb, Croatia School of Medicine University of Zagreb, Zagreb, Croatia
Search for more papers by this authorNoemí Fernández
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Search for more papers by this authorNick de Jonge
Amsterdam UMC, location VUmc, Amsterdam, Netherlands
Search for more papers by this authorCarlo Tascini
Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
Search for more papers by this authorAmalia N. Anastasopoulou
Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Search for more papers by this authorRémy Duléry
Service d’Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Inserm UMRs 938, Paris, France
Search for more papers by this authorMaria Ilaria DEL Principe
HEMatology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
Search for more papers by this authorGaëtan Plantefeve
Head ICU and CRC, Centre Hospitalier Victor DUPOUY, Argenteuil, France
Search for more papers by this authorMario Virgilio Papa
Azienda Ospedaliera Sant’Anna e San Sebastiano, Caserta, Italy
Search for more papers by this authorMarcio Nucci
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Search for more papers by this authorMoraima Carmen Jimenez Balarezo
Department of HEMatology, Vall d’Hebron Hospital Universitari, Experimental HEMatology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
Search for more papers by this authorAvinash Aujayeb
Northumbria Healthcare, Newcastle, United Kingdom
Search for more papers by this authorJose Angel Hernandez Rivas
Hospital Universitario Infanta Leonor, Madrid, Spain Departmento de Medicina, Universidad Complutense de Madrid, Madrid, Spain
Search for more papers by this authorMaria Merelli
Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
Search for more papers by this authorChiara Cattaneo
HEMatology Unit, ASST-Spedali Civili, Brescia, Italy
Search for more papers by this authorOla Blennow
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorAnna Nordlander
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
Search for more papers by this authorAlba Cabirta
Department of HEMatology, Vall d’Hebron Hospital Universitari, Experimental HEMatology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
Search for more papers by this authorGina Varricchio
Azienda Ospedaliera Sant’Anna e San Sebastiano, Caserta, Italy
Search for more papers by this authorMaria Vittoria Sacchi
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
Search for more papers by this authorRaul Cordoba
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorElena Arellano
Department of HEMatology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
Search for more papers by this authorStefanie Gräfe
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorDominik Wolf
Department of HEMatology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
Search for more papers by this authorZiad Emarah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorEmanuele Ammatuna
University Medical Center Groningen, Groningen, Netherlands
Search for more papers by this authorDitte Stampe Hersby
Department of HEMatology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for more papers by this authorSonia Martín-Pérez
Hospital Nuestra Señora de Sonsoles, Ávila, Spain
Search for more papers by this authorRaquel Nunes Rodrigues
Portuguese Institute of Oncology, Lisbon, Portugal
Search for more papers by this authorLaman Rahimli
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Search for more papers by this authorLivio Pagano
HEMatology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy
Search for more papers by this authorOliver A. Cornely
University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany
University of Cologne, Faculty of Medicine, University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany
German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
Search for more papers by this authorBackground: Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients.
Aims: We aime to discover factors associated with mortality in patients receiving nirmatrelvir/ritonavir for the COVID-19 treatment.
Methods: This is a retrospective cohort study from the multicentre EPICOVIDEHA registry on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample.
Additionally, a Cox regression was modelled to detect factors associated with mortality.
Results: A total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received ≥1 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, versus 74% in patients with no nirmatrelvir/ritonavir (p=0.003). Nirmatrelvir/ritonavir recipients were more likely to have received a 2nd vaccine booster than patients without (13% versus 7%, p=0.04), 5% were admitted to ICU, less than patients not receiving nirmatrelvir/ritonavir (12%, p=0.021). Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448-4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619-8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093-0.732) and obesity (aOR 0.105, 95%CI 0.014-0.776) were not associated with nirmatrelvir/ritonavir use. Overall mortality rate was 11%, and COVID-19 attributable mortality was 9%. In patients treated with nirmatrelvir/ritonavir the mortality rate was 7%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (15%, p=0.023). No other factor was observed explaining the mortality difference.
Summary/Conclusion: Haematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was significantly lower than in patients with targeted drugs other than nirmatrelvir/ritonavir.
Keywords: Hematological malignancy, Immune deficiency, COVID-19, Infection
