S149: OTHER MALIGNANCIES IN THE HISTORY OF CLL: THE FINAL ANALYSIS OF THE INTERNATIONAL MULTICENTER STUDY CONDUCTED BY ERIC, IN HARMONY.
Thomas Chatzikonstantinou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorLydia Scarfò
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele
Search for more papers by this authorGeorgios Karakatsoulis
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Department of Mathematics, University of Ioannina, Ioannina, Greece
Search for more papers by this authorEva Minga
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorDimitra Chamou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorGloria Iacoboni
Department of Haematology, University Hospital Vall d’Hebron, Autonomous University, Barcelona, Spain
Search for more papers by this authorJana Kotaskova
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorChristos Demosthenous
Hematology Department and HCT Unit, G. Papanicolaou Hospital., Thessaloniki, Greece
Search for more papers by this authorMiguel Alcoceba
Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC (CB16/12/00233) and Cancer Research Centre (CIC-IBMCC, USAL-CSIC)., Salamanca, Spain
Search for more papers by this authorSalem Al-Shemari
Department of Medicine, Faculty of Medicine, Kuwait University., Kuwait City, Kuwait
Search for more papers by this authorThérèse Aurran-Schleinitz
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorFrancesca Bacchiarri
Division of Hematology, University of Siena, Siena, Italy
Search for more papers by this authorMar Bellido
Hematology Department, University Medical Center Groningen, University of Groningen., Groningen, The Netherlands
Search for more papers by this authorAnne Calleja
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorMehreen Ali Khan
Department of Hematology and Stem Cell Transplant, Armed Forces Bone Marrow Transplant Center/National Institute of Blood and Marrow Transplant, Rawalpindi, Pakistan
Search for more papers by this authorRamona Cassin
Hematology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
Search for more papers by this authorSofia Chatzileontiadou
Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece
Search for more papers by this authorRosa Collado
Servicio de Hematología, Consorcio Hospital General Universitario de Valencia, Spain. Fundación de Investigación Hospital General Universitario de Valencia, Valencia, Spain
Search for more papers by this authorZadie Davis
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorMaria Dimou
Department of Hematology and Bone Marrow transplantation Unit, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorDavid Donaldson
Clinical Haematology, Belfast City Hospital, Belfast, United Kingdom
Search for more papers by this authorBarbara Dreta
Division of hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Search for more papers by this authorMaria Efstathopoulou
Department of Haematology Athens Medical Center-Psychikon Branch, Athens, Greece
Search for more papers by this authorShaimaa El-Ashwah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorAlicia Enrico
Hospital Italiano La Plata, Buenos Aires, Argentina
Search for more papers by this authorAlberto Fresa
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Search for more papers by this authorSara Galimberti
Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy
Search for more papers by this authorAndrea Galitzia
Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS “G. Brotzu”, Cagliari, Italy
Search for more papers by this authorRocío García-Serra
Servicio de Hematología, Consorcio Hospital General Universitario de Valencia, Spain. Fundación de Investigación Hospital General Universitario de Valencia, Valencia, Spain
Search for more papers by this authorEva Gimeno
Department of Hematology, Hospital del Mar, Barcelona, Spain
Search for more papers by this authorIsabel González-Gascón-Y-Marín
Hematology Department Infanta Leonor University Hospital, Madrid, Spain
Search for more papers by this authorAlessandro Gozzetti
Division of Hematology, University of Siena, Siena, Italy
Search for more papers by this authorValerio Guarente
Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy
Search for more papers by this authorRomain Guieze
Department of Hematology and Cell Therapy, Estaing University Hospital, Clermont-Ferrand, France
Search for more papers by this authorAjay Gogia
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorRitu Gupta
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorSean Harrop
Peter MacCallum Cancer Centre, St Vincent’s Hospital, University of Melbourne, Melbourne, Victoria, 3000 Australia
University of Melbourne, Victoria, Australia
Search for more papers by this authorEleftheria Hatzimichael
Department of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece
Search for more papers by this authorYair Herishanu
Department of Hematology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorJosé-Ángel Hernández-Rivas
Hematology Department Infanta Leonor University Hospital, Madrid, Spain
Search for more papers by this authorLuca Inchiappa
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorOzren Jaksic
Department of Hematology, University hospital Dubrava, Zagreb, Croatia
Search for more papers by this authorSusanne Janssen
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorElżbieta Kalicińska
Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University, Wroclaw, Poland
Search for more papers by this authorLaribi Kamel
Department of Hematology, Centre Hospitalier Le Mans, Le Mans, France
Search for more papers by this authorVolkan Karakus
Antalya Training and Research Hospital, Antalya, Turkey
Search for more papers by this authorArnon P Kater
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorBonnie Kho
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
Search for more papers by this authorMaria Kislova
Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin’s City Hospital, Moscow, Russia
Search for more papers by this authorΕliana Konstantinou
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorMaya Koren-Michowitz
Department of Hematology, Shamir Medical Center, Zerifin, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Search for more papers by this authorIoannis Kotsianidis
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
Search for more papers by this authorRobert J Kreitman
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, United States
Search for more papers by this authorJorge Labrador
Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain
Search for more papers by this authorDeepesh Lad
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Search for more papers by this authorMark-David Levin
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands
Search for more papers by this authorThomas Longval
Service d’Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
Search for more papers by this authorAlberto Lopez-Garcia
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorJuan Marquet
Hematology Department, Ramón y Cajal University Hospital, Madrid, Spain
Search for more papers by this authorMarc Maynadié
Biological Haematology Department, Dijon Bourgogne University Hospital, Haematological Malignancies Registry, Dijon, France
Search for more papers by this authorStanislava Maslejova
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorCarlota Mayor-Bastida
Haematology Department, Hospital Universitario de La Princesa, Madrid, Spain
Search for more papers by this authorBiljana Mihaljevic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
Search for more papers by this authorIvana Milosevic
University of Novi Sad, Faculty of Medicine, Clinical Centre of Vojvodina, Novi Sad, Serbia
Search for more papers by this authorFatima Miras
Hematology Department Hospital Universitario 12 de Octubre, Madrid, Spain
Search for more papers by this authorRiccardo Moia
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorMarta Morawska
Experimental Hematooncology Department, Medical University of Lublin, Lublin, Poland
Hematology Department, St. John’s Cancer Center, Lublin, Poland
Search for more papers by this authorRoberta Murru
Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS “G. Brotzu”, Cagliari, Italy
Search for more papers by this authorUttam Kumar Nath
Department of Medical Oncology & Hematology, All India Institute of Medical Sciences, Rishikesh, India
Search for more papers by this authorAlmudena Navarro-Bailón
Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC (CB16/12/00233) and Cancer Research Centre (CIC-IBMCC, USAL-CSIC)., Salamanca, Spain
Search for more papers by this authorAna C. Oliveira
Department of Clinical Hematology, ICO, Hospital Duran i Reynals, IDIBELL, Barcelona, Spain
Search for more papers by this authorDavid Oscier
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorIrina Panovska-Stavridis
University Clinic of Hematology, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Macedonia
Search for more papers by this authorMaria Papaioannou
Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece
Search for more papers by this authorTomas Papajík
Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic
Search for more papers by this authorPunyarat Phumphukhieo
Hull York Medical School, Hull, United Kingdom
Search for more papers by this authorCheyenne Pierie
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorAnna Puiggros
Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar and Translational Research on Hematological Neoplasms Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
Search for more papers by this authorLata Rani
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorGianluigi Reda
Hematology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
Search for more papers by this authorGian Matteo Rigolin
St. Anna University Hospital, Ferrara, Italy
Search for more papers by this authorAharon Ronson
Department of Hematology, Shaare-Zedek Medical Center, affiliated with the Hebrew University Medical School, Jerusalem, Israel
Search for more papers by this authorRosa Ruchlemer
Department of Hematology, Shaare-Zedek Medical Center, affiliated with the Hebrew University Medical School, Jerusalem, Israel
Search for more papers by this authorMarcos Daniel de Deus Santos
Universidade Federal do Espírito Santo, Internal Medicine Department, Vila Velha, ES, Brazil
Search for more papers by this authorMattia Schipani
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorAnnett Schiwitza
Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
Search for more papers by this authorMartin Simkovic
4th Department of Internal Medicine -Haematology, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
Search for more papers by this authorSvetlana Smirnova
Consultative Hematology Department with a Day Hospital for Intensive High-Dose Chemotherapy, National Medical Research Center for Hematology, Moscow, Russia
Search for more papers by this authorDina Sameh Abdelrahman Soliman
Hematopathology Laboratory, Hamad Medical Corporation, Doha, Qatar
Search for more papers by this authorMartin Spacek
1st Department of Medicine - Hematology, First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic
Search for more papers by this authorTamar Tadmor
Hematology, Bnai-Zion Medical Center, Haifa, Israel
Search for more papers by this authorKristina Tomic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
Search for more papers by this authorEric Tse
Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, Hong Kong
Search for more papers by this authorTheodoros Vassilakopoulos
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorAndrea Visentin
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy
Search for more papers by this authorCandida Vitale
Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Search for more papers by this authorJulia von Tresckow
Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorGeorge Vrachiolias
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
Search for more papers by this authorVojin Vukovic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
University of Belgrade Faculty of Medicine, Belgrade, Serbia
Search for more papers by this authorRenata Walewska
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorEwa Wasik-Szczepanek
Dept. Hematooncology and Bone Marrow Transplantation Medical University in Lublin, Lublin, Poland
Search for more papers by this authorZhenshu Xu
Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
Search for more papers by this authorLucrecia Yañez
Hematology Department, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain
Search for more papers by this authorMohamed Yassin
Hematology section, Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar
Search for more papers by this authorJana Zuchnicka
Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic
Search for more papers by this authorMaria Angelopoulou
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorDarko Antic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
University of Belgrade Faculty of Medicine, Belgrade, Serbia
Search for more papers by this authorBella Biderman
Department of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia
Search for more papers by this authorMark Catherwood
Clinical Haematology, Belfast City Hospital, Belfast, United Kingdom
Search for more papers by this authorRainer Claus
Pathology, Faculty of Medicine, University of Augsburg, Stenglinstrasse 2, Augsburg, Germany
Comprehensive Cancer Center Augsburg, Faculty of Medicine, University of Augsburg, Stenglinstrasse 2, Augsburg, Germany
Search for more papers by this authorMarta Coscia
Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Search for more papers by this authorFatih Demirkan
Dokuz Eylul University, Division of Hematology, Izmir, Turkey
Search for more papers by this authorBlanca Espinet
Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar and Translational Research on Hematological Neoplasms Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
Search for more papers by this authorGianluca Gaidano
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorOlga Kalashnikova
Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, St. Petersburg, Russia
Search for more papers by this authorLuca Laurenti
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Search for more papers by this authorEugene Nikitin
Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin’s City Hospital, Moscow, Russia
Search for more papers by this authorGerassimos A. Pangalis
Department of Haematology Athens Medical Center-Psychikon Branch, Athens, Greece
Search for more papers by this authorPanagiotis Panagiotidis
Department of Hematology and Bone Marrow transplantation Unit, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorViola Maria Popov
Hematology Department Colentina Clinical Hospital, Bucharest, Romania
Search for more papers by this authorSarka Pospisilova
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Search for more papers by this authorLukas Smolej
4th Department of Internal Medicine -Haematology, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
Search for more papers by this authorPaolo Sportoletti
Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy
Search for more papers by this authorNiki Stavroyianni
Hematology Department and HCT Unit, G. Papanicolaou Hospital., Thessaloniki, Greece
Search for more papers by this authorConstantine Tam
Peter MacCallum Cancer Centre, St Vincent’s Hospital, University of Melbourne, Melbourne, Victoria, 3000 Australia
University of Melbourne, Victoria, Australia
Search for more papers by this authorLivio Trentin
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy
Search for more papers by this authorAnastasia Chatzidimitriou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorFrancesc Bosch
Department of Haematology, University Hospital Vall d’Hebron, Autonomous University, Barcelona, Spain
Search for more papers by this authorMichael Doubek
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorPaolo Ghia
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele
Search for more papers by this authorKostas Stamatopoulos
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorThomas Chatzikonstantinou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorLydia Scarfò
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele
Search for more papers by this authorGeorgios Karakatsoulis
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Department of Mathematics, University of Ioannina, Ioannina, Greece
Search for more papers by this authorEva Minga
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorDimitra Chamou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorGloria Iacoboni
Department of Haematology, University Hospital Vall d’Hebron, Autonomous University, Barcelona, Spain
Search for more papers by this authorJana Kotaskova
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorChristos Demosthenous
Hematology Department and HCT Unit, G. Papanicolaou Hospital., Thessaloniki, Greece
Search for more papers by this authorMiguel Alcoceba
Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC (CB16/12/00233) and Cancer Research Centre (CIC-IBMCC, USAL-CSIC)., Salamanca, Spain
Search for more papers by this authorSalem Al-Shemari
Department of Medicine, Faculty of Medicine, Kuwait University., Kuwait City, Kuwait
Search for more papers by this authorThérèse Aurran-Schleinitz
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorFrancesca Bacchiarri
Division of Hematology, University of Siena, Siena, Italy
Search for more papers by this authorMar Bellido
Hematology Department, University Medical Center Groningen, University of Groningen., Groningen, The Netherlands
Search for more papers by this authorAnne Calleja
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorMehreen Ali Khan
Department of Hematology and Stem Cell Transplant, Armed Forces Bone Marrow Transplant Center/National Institute of Blood and Marrow Transplant, Rawalpindi, Pakistan
Search for more papers by this authorRamona Cassin
Hematology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
Search for more papers by this authorSofia Chatzileontiadou
Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece
Search for more papers by this authorRosa Collado
Servicio de Hematología, Consorcio Hospital General Universitario de Valencia, Spain. Fundación de Investigación Hospital General Universitario de Valencia, Valencia, Spain
Search for more papers by this authorZadie Davis
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorMaria Dimou
Department of Hematology and Bone Marrow transplantation Unit, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorDavid Donaldson
Clinical Haematology, Belfast City Hospital, Belfast, United Kingdom
Search for more papers by this authorBarbara Dreta
Division of hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Search for more papers by this authorMaria Efstathopoulou
Department of Haematology Athens Medical Center-Psychikon Branch, Athens, Greece
Search for more papers by this authorShaimaa El-Ashwah
Oncology Center, Mansoura University, Mansoura, Egypt
Search for more papers by this authorAlicia Enrico
Hospital Italiano La Plata, Buenos Aires, Argentina
Search for more papers by this authorAlberto Fresa
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Search for more papers by this authorSara Galimberti
Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy
Search for more papers by this authorAndrea Galitzia
Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS “G. Brotzu”, Cagliari, Italy
Search for more papers by this authorRocío García-Serra
Servicio de Hematología, Consorcio Hospital General Universitario de Valencia, Spain. Fundación de Investigación Hospital General Universitario de Valencia, Valencia, Spain
Search for more papers by this authorEva Gimeno
Department of Hematology, Hospital del Mar, Barcelona, Spain
Search for more papers by this authorIsabel González-Gascón-Y-Marín
Hematology Department Infanta Leonor University Hospital, Madrid, Spain
Search for more papers by this authorAlessandro Gozzetti
Division of Hematology, University of Siena, Siena, Italy
Search for more papers by this authorValerio Guarente
Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy
Search for more papers by this authorRomain Guieze
Department of Hematology and Cell Therapy, Estaing University Hospital, Clermont-Ferrand, France
Search for more papers by this authorAjay Gogia
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorRitu Gupta
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorSean Harrop
Peter MacCallum Cancer Centre, St Vincent’s Hospital, University of Melbourne, Melbourne, Victoria, 3000 Australia
University of Melbourne, Victoria, Australia
Search for more papers by this authorEleftheria Hatzimichael
Department of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece
Search for more papers by this authorYair Herishanu
Department of Hematology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorJosé-Ángel Hernández-Rivas
Hematology Department Infanta Leonor University Hospital, Madrid, Spain
Search for more papers by this authorLuca Inchiappa
Department of Hemato-Oncology, Institut Paoli Calmette, Marseille, France
Search for more papers by this authorOzren Jaksic
Department of Hematology, University hospital Dubrava, Zagreb, Croatia
Search for more papers by this authorSusanne Janssen
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorElżbieta Kalicińska
Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University, Wroclaw, Poland
Search for more papers by this authorLaribi Kamel
Department of Hematology, Centre Hospitalier Le Mans, Le Mans, France
Search for more papers by this authorVolkan Karakus
Antalya Training and Research Hospital, Antalya, Turkey
Search for more papers by this authorArnon P Kater
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorBonnie Kho
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
Search for more papers by this authorMaria Kislova
Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin’s City Hospital, Moscow, Russia
Search for more papers by this authorΕliana Konstantinou
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorMaya Koren-Michowitz
Department of Hematology, Shamir Medical Center, Zerifin, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Search for more papers by this authorIoannis Kotsianidis
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
Search for more papers by this authorRobert J Kreitman
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, United States
Search for more papers by this authorJorge Labrador
Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain
Search for more papers by this authorDeepesh Lad
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Search for more papers by this authorMark-David Levin
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands
Search for more papers by this authorThomas Longval
Service d’Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
Search for more papers by this authorAlberto Lopez-Garcia
Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
Search for more papers by this authorJuan Marquet
Hematology Department, Ramón y Cajal University Hospital, Madrid, Spain
Search for more papers by this authorMarc Maynadié
Biological Haematology Department, Dijon Bourgogne University Hospital, Haematological Malignancies Registry, Dijon, France
Search for more papers by this authorStanislava Maslejova
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorCarlota Mayor-Bastida
Haematology Department, Hospital Universitario de La Princesa, Madrid, Spain
Search for more papers by this authorBiljana Mihaljevic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
Search for more papers by this authorIvana Milosevic
University of Novi Sad, Faculty of Medicine, Clinical Centre of Vojvodina, Novi Sad, Serbia
Search for more papers by this authorFatima Miras
Hematology Department Hospital Universitario 12 de Octubre, Madrid, Spain
Search for more papers by this authorRiccardo Moia
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorMarta Morawska
Experimental Hematooncology Department, Medical University of Lublin, Lublin, Poland
Hematology Department, St. John’s Cancer Center, Lublin, Poland
Search for more papers by this authorRoberta Murru
Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS “G. Brotzu”, Cagliari, Italy
Search for more papers by this authorUttam Kumar Nath
Department of Medical Oncology & Hematology, All India Institute of Medical Sciences, Rishikesh, India
Search for more papers by this authorAlmudena Navarro-Bailón
Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC (CB16/12/00233) and Cancer Research Centre (CIC-IBMCC, USAL-CSIC)., Salamanca, Spain
Search for more papers by this authorAna C. Oliveira
Department of Clinical Hematology, ICO, Hospital Duran i Reynals, IDIBELL, Barcelona, Spain
Search for more papers by this authorDavid Oscier
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorIrina Panovska-Stavridis
University Clinic of Hematology, Medical Faculty, University Ss. Cyril and Methodius, Skopje, Macedonia
Search for more papers by this authorMaria Papaioannou
Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece
Search for more papers by this authorTomas Papajík
Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic
Search for more papers by this authorPunyarat Phumphukhieo
Hull York Medical School, Hull, United Kingdom
Search for more papers by this authorCheyenne Pierie
Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorAnna Puiggros
Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar and Translational Research on Hematological Neoplasms Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
Search for more papers by this authorLata Rani
Laboratory Oncology Unit, Dr. B.R.A. IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Search for more papers by this authorGianluigi Reda
Hematology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
Search for more papers by this authorGian Matteo Rigolin
St. Anna University Hospital, Ferrara, Italy
Search for more papers by this authorAharon Ronson
Department of Hematology, Shaare-Zedek Medical Center, affiliated with the Hebrew University Medical School, Jerusalem, Israel
Search for more papers by this authorRosa Ruchlemer
Department of Hematology, Shaare-Zedek Medical Center, affiliated with the Hebrew University Medical School, Jerusalem, Israel
Search for more papers by this authorMarcos Daniel de Deus Santos
Universidade Federal do Espírito Santo, Internal Medicine Department, Vila Velha, ES, Brazil
Search for more papers by this authorMattia Schipani
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorAnnett Schiwitza
Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
Search for more papers by this authorMartin Simkovic
4th Department of Internal Medicine -Haematology, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
Search for more papers by this authorSvetlana Smirnova
Consultative Hematology Department with a Day Hospital for Intensive High-Dose Chemotherapy, National Medical Research Center for Hematology, Moscow, Russia
Search for more papers by this authorDina Sameh Abdelrahman Soliman
Hematopathology Laboratory, Hamad Medical Corporation, Doha, Qatar
Search for more papers by this authorMartin Spacek
1st Department of Medicine - Hematology, First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic
Search for more papers by this authorTamar Tadmor
Hematology, Bnai-Zion Medical Center, Haifa, Israel
Search for more papers by this authorKristina Tomic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
Search for more papers by this authorEric Tse
Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, Hong Kong
Search for more papers by this authorTheodoros Vassilakopoulos
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorAndrea Visentin
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy
Search for more papers by this authorCandida Vitale
Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Search for more papers by this authorJulia von Tresckow
Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorGeorge Vrachiolias
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece
Search for more papers by this authorVojin Vukovic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
University of Belgrade Faculty of Medicine, Belgrade, Serbia
Search for more papers by this authorRenata Walewska
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
Search for more papers by this authorEwa Wasik-Szczepanek
Dept. Hematooncology and Bone Marrow Transplantation Medical University in Lublin, Lublin, Poland
Search for more papers by this authorZhenshu Xu
Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
Search for more papers by this authorLucrecia Yañez
Hematology Department, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain
Search for more papers by this authorMohamed Yassin
Hematology section, Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar
Search for more papers by this authorJana Zuchnicka
Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic
Search for more papers by this authorMaria Angelopoulou
Haematology, University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorDarko Antic
Clinic for hematology, University Clinical Center of Serbia, Belgrade, Serbia
University of Belgrade Faculty of Medicine, Belgrade, Serbia
Search for more papers by this authorBella Biderman
Department of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia
Search for more papers by this authorMark Catherwood
Clinical Haematology, Belfast City Hospital, Belfast, United Kingdom
Search for more papers by this authorRainer Claus
Pathology, Faculty of Medicine, University of Augsburg, Stenglinstrasse 2, Augsburg, Germany
Comprehensive Cancer Center Augsburg, Faculty of Medicine, University of Augsburg, Stenglinstrasse 2, Augsburg, Germany
Search for more papers by this authorMarta Coscia
Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Search for more papers by this authorFatih Demirkan
Dokuz Eylul University, Division of Hematology, Izmir, Turkey
Search for more papers by this authorBlanca Espinet
Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar and Translational Research on Hematological Neoplasms Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
Search for more papers by this authorGianluca Gaidano
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Search for more papers by this authorOlga Kalashnikova
Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, St. Petersburg, Russia
Search for more papers by this authorLuca Laurenti
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Search for more papers by this authorEugene Nikitin
Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin’s City Hospital, Moscow, Russia
Search for more papers by this authorGerassimos A. Pangalis
Department of Haematology Athens Medical Center-Psychikon Branch, Athens, Greece
Search for more papers by this authorPanagiotis Panagiotidis
Department of Hematology and Bone Marrow transplantation Unit, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Search for more papers by this authorViola Maria Popov
Hematology Department Colentina Clinical Hospital, Bucharest, Romania
Search for more papers by this authorSarka Pospisilova
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Search for more papers by this authorLukas Smolej
4th Department of Internal Medicine -Haematology, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
Search for more papers by this authorPaolo Sportoletti
Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy
Search for more papers by this authorNiki Stavroyianni
Hematology Department and HCT Unit, G. Papanicolaou Hospital., Thessaloniki, Greece
Search for more papers by this authorConstantine Tam
Peter MacCallum Cancer Centre, St Vincent’s Hospital, University of Melbourne, Melbourne, Victoria, 3000 Australia
University of Melbourne, Victoria, Australia
Search for more papers by this authorLivio Trentin
Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy
Search for more papers by this authorAnastasia Chatzidimitriou
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorFrancesc Bosch
Department of Haematology, University Hospital Vall d’Hebron, Autonomous University, Barcelona, Spain
Search for more papers by this authorMichael Doubek
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for more papers by this authorPaolo Ghia
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele
Search for more papers by this authorKostas Stamatopoulos
Institute of Applied Biosciences, Centre for Research and Technology Hellas
Search for more papers by this authorBackground: Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear.
Aims: We aimed to (i) determine the incidence of OMs in a population of patients with CLL, (ii) assess the overall survival (OS) of patients with CLL and OM, and (iii) find risk factors for the occurrence of OM in patients with CLL.
Methods: This is a retrospective international multicenter study conducted by the European Research Initiative on CLL, in the context of HARMONY. Investigators at each participating site provided data on consecutive sets of patients diagnosed with CLL/small lymphocytic lymphoma (SLL) or high-count CLL-like monoclonal B-cell lymphocytosis (MBL) between 2000-2016. The study was approved by the local institutional ethics committees.
Results: Data on 19,705 patients from 85 different centers in 33 countries was collected. The median age at CLL diagnosis was 65 years [interquartile range (IQR) 57-73], and the median follow-up from CLL diagnosis was 6.2 years (IQR 3.72-9.6). The majority of patients had CLL (18,386, 93.3%), while 528 (2.7%) and 791 (4%) were diagnosed with SLL and MBL, respectively. At last follow-up, 10,146 (53%) patients had received at least one line of treatment (median 1, IQR 1-2).
Diagnosis of OM was reported in 4,134/19,705 (21%) patients with CLL [633 (3.2%) had Richter transformation (RT) or B cell prolymphocytic leukemia]. In 2,910/4,134 (70.4%) patients, the OM postdated the diagnosis of CLL; in 854/4,134 (20.6%), the OM either antedated or was diagnosed concurrently with CLL; finally, in 322/4,134 (7.8%), an OM was diagnosed both before and after CLL diagnosis. Overall, 3,513 OMs were diagnosed in 130,166.9 years of follow-up after CLL diagnosis (26.9 OMs/1,000 person-years).
The most common hematological OMs were myelodysplastic syndrome (MDS) (87/19,705, 0.44%), followed by acute myeloid leukemia (AML) (42/19,705, 0.21%) and multiple myeloma (37/19,705, 0.19%). Treatment with fludarabine and cyclophosphamide with/without rituximab (FC+/-R) was the only statistically significant risk factor for MDS/AML in the multivariate analysis, while only 13q deletions were associated with hematological OMs (excluding MDS/AML and RT).
Non-melanoma skin cancers (NMSC) (986/19,705, 5%) and prostate cancers (PCs) (530/19,705, 2.7%) were the most frequent solid tumors (ST), followed by colon (382/19,705, 1.9%) and breast cancers (343/19,705, 1.7%). Male patients and those with unmutated immunoglobulin heavy variable (IGHV) gene status had a higher risk of developing an ST (excluding NMSC).
The most frequent STs (>100 cases) were analyzed separately and statistically significant (p<0.05) associations were found between (i) NMSC development and male gender, older age at diagnosis, and FC+/-R treatment; (ii) male gender and colorectal and bladder cancers; (iii) unmutated IGHV gene status and melanoma, lung and breast cancers.
The effect of CLL-directed treatment varied between different STs. Treated patients were more likely to develop NMSC and PC (OR=1.8;95%CI=1.36-2.41; p<0.001/OR=2.11;95%CI=1.12-3.97; p=0.021), while breast cancers were more frequent in untreated patients (OR=0.17;95%CI=0.08-0.33; p<0.001).
Patients with CLL and an OM had inferior OS than those without. MDS/AML conferred the worst OS (Figure).
Summary/Conclusion: OMs in CLL impact on OS. FC+/-R is associated with increased risk of MDS/AML. Accurate assessment of the risk of OMs in patients treated with chemo-free regimens requires further investigation.
Keywords: B cell chronic lymphocytic leukemia