Relation Between Basic and Clinical Electrophysiologic Characteristics in Brugada Syndrome: Facts or Fiction?
ARTHUR A.M. WILDE M.D. PhD.,
ARTHUR A.M. WILDE M.D. PhD.
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this author HANNO L. TAN M.D. PhD.,
HANNO L. TAN M.D. PhD.
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this author
ARTHUR A.M. WILDE M.D. PhD.,
ARTHUR A.M. WILDE M.D. PhD.
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this author HANNO L. TAN M.D. PhD.,
HANNO L. TAN M.D. PhD.
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this author
First published: 23 April 2003
Address for correspondence: Arthur A.M. Wilde, M.D., Ph.D., Experimental and Molecular Cardiology Group, Academic Medical Center, Room M0-052, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands. Fax: 31-20-6975458; E-mail:
[email protected]
No abstract is available for this article.
References
- 1
Brugada P,
Brugada J: Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome.
J Am Coll Cardiol
1992; 20: 1391-1396.
- 2
Wilde AAM,
Antzelevitch C,
Borggrefe M,
Brugada J,
Brugada R,
Brugada P,
Corrado D,
Hauer RNW,
Kass RS,
Nademanee K,
Priori SG,
Towbin JA, for the study group on the molecular basis of arrhythmias of the European Society of Cardiology. Proposed diagnostic criteria for the Brugada syndrome: A consensus report.
Eur Heart J
2002; 23: 1648-1654.
- 3
Mok N-S,
Priori SG,
Napolitano C,
Chan N-Y,
Chahine M,
Baroudi G.
A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia.
J Cardiovasc Electrophysiol
2003; 14: 407-411.
- 4
Alings M,
Wilde A: “Brugada” syndrome: Clinical data and suggested pathophysiological mechanism.
Circulation
1999; 99: 666-673.
- 5
Weiss R,
Barmada MM,
Nguyen T,
Seibel JS,
Cavlovich D,
Kornblit CA,
Angelilli A,
Villanueva F,
McNamara DM,
London B: Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3.
Circulation
2002; 105: 707-713.
- 6
Tan HL,
Bezzina CR,
Smits JPP,
Verkerk AO,
Wilde AAM: Genetic control of sodium channel function.
Cardiovasc Res
2003; 57: 961-973.
- 7
Smits JPP,
Eckardt L,
Probst V,
Bezzina CR,
Schott JJ,
Remme CA,
Haverkamp W,
Breithardt G,
Escande D,
Schulze-Bahr E,
Le Marec H,
Wilde AAM: Genotype-phenotype relationship in Brugada syndrome: Electrocardiographic features differentiate SCN5A-related patients from non SCN5A related patients.
J Am Coll Cardiol
2002; 40: 350-356.
- 8
Dumaine R,
Towbin JA,
Brugada P,
Vatta M,
Nesterenko DV,
Nesterenko VV,
Brugada J,
Brugada R,
Antzelevitch C: Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent.
Circ Res
1999; 85: 803-809.
- 9
Saura D,
García-Alberola A,
Carrillo P,
Pascual D,
Martínez-Sanchez J,
Valdés M: Brugada-like electrocardiographic pattern induced by fever.
Pacing Clin Electrophysiol
2002; 25: 856-859.
- 10
Tan HL,
Bink-Boelkens MT,
Bezzina CR,
Viswanathan PC,
Beaufort-Krol GCM,
Van Tintelen JP,
Van den Berg MP,
Wilde AAM,
Balser JR: A sodium-channel mutation causes isolated cardiac conduction disease.
Nature
2001; 409: 1043-1047.
- 11
Antzelevitch C: The Brugada syndrome: diagnostic criteria and cellular mechanisms.
Eur Heart J
2001; 22: 356-363.
- 12
Wedekind H,
Smits JPP,
Schulze-Bahr E,
Arnold R,
Veldkamp MW,
Bajanowski T,
Borggrefe M. Brinkmann B,
Warnecke I,
Funke H,
Bhuiyan ZA,
Wilde AAM,
Breithardt G, Haverkamp W: De novo mutation in the SCN5A gene associated with early onset of sudden infant death.
Circulation
2001; 104: 1158-1164.
- 13
Wang DW,
Yazawa K,
George AL,
Bennett PB: Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.
Proc Natl Acad Sci USA
1996; 93: 13200-13205.
- 14
Ong BH,
Tomaselli GF,
Balser JR: A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.
J Gen Physiol
2000; 116: 653-661.
- 15
Tan HL,
Kupershmidt S,
Zhang R,
Stepanovic S,
Roden DM,
Wilde AAM,
Anderson ME,
Balser JR: A calcium sensor in the sodium channel modulates cardiac excitability.
Nature
2002; 415: 442-447.
- 16
Pu J,
Balser JR,
Boyden PA: Lidocaine actions on Na+ currents in ventricular myocytes from the epicardial border zone of the infarcted heart.
Circ Res
1998; 83: 431-440.
- 17
Veldkamp MW,
Viswanathan PC,
Bezzina C,
Baartscheer A,
Wilde AAM,
Balser JR: Two distinct congenital arrhythmias evoked by a multidysfunctional Na+ channel.
Circ Res
2000; 86: e91-e97.