Intracisternal octreotide does not ameliorate orthodromic trigeminovascular nociception
RHA Kemper,
M Jeuring,
WJ Meijler,
J Korf,
GJ Ter Horst,
RHA Kemper
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorM Jeuring
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorWJ Meijler
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorJ Korf
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorGJ Ter Horst
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorRHA Kemper,
M Jeuring,
WJ Meijler,
J Korf,
GJ Ter Horst,
RHA Kemper
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorM Jeuring
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorWJ Meijler
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorJ Korf
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this authorGJ Ter Horst
Department of Psychiatry and Anaesthesiology/Pain Centre, University and Academic Hospital Groningen, Groningen, The Netherlands
Search for more papers by this author
Gert J. Ter Horst, Department of Psychiatry, Rm 7.15, University Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands. Tel. 31 50 3612105, fax. 31 50 3611699, e-mail:
[email protected] Received 6 August 1999, accepted 31 March 2000
Abstract
Octreotide is a long-acting somatostatin analogue that has been effectively used to treat migraine. Octreotide poorly penetrates the blood–brain barrier, but has potential central target sites in the trigeminal nucleus caudalis, which is the primary central relay station for trigeminal nociceptive information in the brain. We studied the effect of intracisternally applied octreotide in a model of trigeminovascular stimulation in the unrestrained rat using intracisternal capsaicin infusion to stimulate intracranial trigeminal nerves. Fos expression in the outer layers of the trigeminal nucleus caudalis (TNC I-II) and behavioural analysis were used to measure the effects of octreotide on capsaicin-induced trigeminovascular activation. Increases of head grooming and scratching behaviour are an indication of octreotide-induced trigeminal activation. However, octreotide did not alter the average capsaicin-induced Fos expression in the TNC I-II and capsaicin sensitive behaviours were not modified by octreotide pre-treatment. This argues against a role for central (TNC I-II) somatostatin receptors in the processing of the nociceptive trigeminovascular signals.
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