The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene ^†

Risk

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Mills,

Mills

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Garde,

Garde

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Dunn,

Dunn

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Evans,

Evans

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Hollstein,

Hollstein

German Cancer Research Center, Im Neunheimer Feld 280, D-69120 Heidelberg, Germany

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Field,

Field

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Risk,

Risk

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Mills,

Mills

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Garde,

Garde

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Dunn,

Dunn

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Evans,

Evans

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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Hollstein,

Hollstein

German Cancer Research Center, Im Neunheimer Feld 280, D-69120 Heidelberg, Germany

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Field,

Field

Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK,

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First published: 24 December 2001

https://doi.org/10.1046/j.1442-2050.1999.00042.x

Citations: 3

Field Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool L69 3BX, UK. Tel: (+44) 151 794 8900; Fax: (+44) 151 794 8989.

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Abstract

Tylosis (focal non-epidermolytic palmoplantar keratoderma; NEPPK) is associated with esophageal cancer in three families, two of which contain six or seven generations. The causative locus, the tylosis esophageal cancer (TOC) gene, has been localized to a small region on chromosome 17q25. Recent loss of heterozygosity (LOH) studies have indicated a role for the TOC gene in sporadic squamous cell esophageal cancer and Barrett’s adenocarcinoma. We have now integrated genetic and physical mapping data from the TOC region, based on microsatellite markers and radiation hybrid, yeast (YAC), bacterial (BAC) and P1 artificial chromosomal (PAC) clones, and formed a partial minimal contig of one non-chimeric YAC (330 kb) and one PAC. Twenty-three candidate genes, including envoplakin (EVPL), were mapped against this contig, but only one was shown to be located within the minimal region. This physical map will allow further characterization of the region and identification of a gene implicated in both familial and sporadic squamous cell esophageal carcinoma and Barrett’s adenocarcinoma.

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Volume12, Issue3

November 1999

Pages 173-176

The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene ^†

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The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene †

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The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene ^†