Volume 114, Issue 1 pp. 198-200

Autoimmune neutropenia in pregnant women causing neonatal neutropenia

Junichi Kameoka

Junichi Kameoka

Department of Rheumatology and Haematology,

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Tadao Funato

Tadao Funato

Department of Molecular Diagnostics, Tohoku University School of Medicine,

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Toshihiko Miura

Toshihiko Miura

Department of Molecular Diagnostics, Tohoku University School of Medicine,

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Hideo Harigae

Hideo Harigae

Department of Molecular Diagnostics, Tohoku University School of Medicine,

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Junko Saito

Junko Saito

Department of Paediatrics, Kosei Nenkin Hospital,

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Hisayuki Yokoyama

Hisayuki Yokoyama

Department of Rheumatology and Haematology,

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Shinichiro Takahashi

Shinichiro Takahashi

Department of Rheumatology and Haematology,

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Minami Yamada

Minami Yamada

Department of Rheumatology and Haematology,

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Osamu Sasaki

Osamu Sasaki

Department of Rheumatology and Haematology,

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Masue Imaizumi

Masue Imaizumi

Department of Paediatric Haematology and Oncology, Tohoku University School of Medicine, Sendai, and

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Noboru Takata

Noboru Takata

Division of Blood Transfusion Services, Hiroshima University Medical Hospital, Hiroshima, Japan

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Kuniaki Meguro

Kuniaki Meguro

Department of Rheumatology and Haematology,

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Takeshi Sasaki

Takeshi Sasaki

Department of Rheumatology and Haematology,

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First published: 12 January 2002
Citations: 21
Junichi Kameoka, M.D. PhD., Department of Rheumatology and Haematology, Tohoku University School of Medicine, 1–1, Seiryo-cho, Aoba-ku, Sendai, 980–8572, Japan. E-mail: [email protected]

Abstract

Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal neutropenia occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of AIN during pregnancy, both of which caused severe yet transient neonatal neutropenia (< 0·3 × 109/l), probably as a result of transplacental maternal anti-neutrophil autoantibodies. The anti-neutrophil antibodies seemed to be against antigens other than NA1/NA2 because the autoantibodies did not bind to neutrophils of specific NA types selectively in the granulocyte indirect immunofluorescence test. Although AIN is a relatively uncommon disease, neonatal neutropenia caused by maternal AIN may not be quite as rare.

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