TOPOISOMERASE II INHIBITOR-RELATED ACUTE MYELOID LEUKAEMIA
Ching-Hon Pui,
Mary V. Relling,
Ching-Hon Pui
St Jude Children's Research Hospital and the University of Tennessee, Memphis, TN, USA
Search for more papers by this authorMary V. Relling
St Jude Children's Research Hospital and the University of Tennessee, Memphis, TN, USA
Search for more papers by this authorChing-Hon Pui,
Mary V. Relling,
Ching-Hon Pui
St Jude Children's Research Hospital and the University of Tennessee, Memphis, TN, USA
Search for more papers by this authorMary V. Relling
St Jude Children's Research Hospital and the University of Tennessee, Memphis, TN, USA
Search for more papers by this authorDr Ching-Hon Pui St Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105.

References
- 1 Albain, K.S., Le Beau, M.M., Ullirsch, R., Schumacher, H. (1990) Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation. Genes, Chromosomes and Cancer, 2, 53 58.
- 2 Amylon, M.D., Shuster, J., Pullen, J., Berard, C., Link, M.P., Wharam, M., Katz, J., Yu, A., Laver, J., Ravindranath, Y., Kurtzberg, J., Desai, S., Camitta, B., Murphy, S.B. (1999) Intensive high-dose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advanced stage lymphoblastic lymphoma: a Pediatric Oncology Group study. Leukemia, 13, 335 342.
- 3 Andersen, M.K., Johansson, B., Larsen, S.O., Pedersen-Bjergaard, J. (1998) Chromosomal abnormalities in secondary MDS and AML. Relationship to drugs and radiation with specific emphasis on the balanced rearrangements. Haematologica, 83, 483 488.
- 4
Andersson, M.,
Philip, P.,
Pedersen-Bjergaard, J. (1990) High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer.
Cancer, 65, 2460 2464.
10.1002/1097-0142(19900601)65:11<2460::AID-CNCR2820651110>3.0.CO;2-S CAS PubMed Web of Science® Google Scholar
- 5 Aplan, P.D., Chervinsky, D.S., Stanulla, M., Burhans, W.C. (1996) Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood, 87, 2649 2658.
- 6 Archimbaud, E., Charrin, C., Magaud, J.P., Campos, L., Thomas, X., Fiere, D., Rimokh, R. (1998) Clinical and biological characteristics of adult de novo and secondary acute myeloid leukemia with balanced 11q23 chromosomal anomaly or MLL gene rearrangement compared to cases with unbalanced 11q23 anomaly: confirmation of the existence of different entities with 11q23 breakpoint. Leukemia, 12, 25 33.
- 7 Arnold, R., De Witte, T., Van Biezen, A., Hermans, J., Jacobsen, N., Runde, V., Gratwohl, A., Apperley, J.F. (1998) Unrelated bone marrow transplantation in patients with myelodysplastic syndromes and secondary acute myeloid leukemia: an EBMT survey. European Blood and Marrow Transplantation Group. Bone Marrow Transplantation, 21, 1213 1216.
- 8 Atlas, M., Head, D., Behm, F., Schmidt, E., Zeleznik-Le, N.H., Roe, B.A., Burian, D., Domer, P.H. (1998) Cloning and sequence analysis of four t (9;11) therapy-related leukemia breakpoints. Leukemia, 12, 1895 1902.
- 9 Bajorin, D.F., Motzer, R.J., Rodriguez, E., Murphy, B., Bosl, G.J. (1993) Acute nonlymphocytic leukemia in germ cell tumor patients treated with etoposide-containing chemotherapy. Journal of the National Cancer Institute, 85, 60 62.
- 10 Bokemeyer, C. & Schmoll, H.J. (1995) Treatment of testicular cancer and the development of secondary malignancies. Journal of Clinical Oncology, 13, 283 292.
- 11 Bokemeyer, C., Schmoll, H.J., Kuczyk, M.A., Beyer, J., Siegert, W. (1995) Risk of secondary leukemia following high cumulative doses of etoposide during chemotherapy for testicular cancer. Journal of the National Cancer Institute, 87, 58 60.
- 12 Boshoff, C., Begent, R.H., Oliver, R.T., Rustin, G.J., Newlands, E.S., Andrews, R., Skelton, M., Holden, L., Ong, J. (1995) Secondary tumours following etoposide containing therapy for germ cell cancer. Annals of Oncology, 6, 35 40.
- 13 Broeker, P.L., Super, H.G., Thirman, M.J., Pomykala, H., Yonebayashi, Y., Tanabe, S., Zeleznik-Le, N., Rowley, J.D. (1996) Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood, 87, 1912 1922.
- 14 Cavalli-Sforza, L.L. (1998) The DNA revolution in population genetics. Trends in Genetics, 14, 60 65.
- 15 Chen, C.-L., Fuscoe, J.C., Liu, Q., Relling, M.V. (1996a) Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells. Blood, 89, 2210 2218.
- 16 Chen, C.-L., Fuscoe, J.C., Liu, Q., Pui, C.-H., Mahmoud, H.H., Relling, M.V. (1996b) Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide. Journal of the National Cancer Institute, 88, 1840 1847.
- 17 Chiang, P.K., Gordon, R.K., Tal, J., Zeng, G.C., Doctor, B.P., Pardhasaradhi, K., McCann, P.P. (1996) S-Adenosylmethionine and methylation. FASEB Journal, 10, 471 480.
- 18 Cimino, G., Moir, D.T., Canaani, O., Williams, K., Crist, W.M., Katzav, S., Cannizzaro, L., Lange, B., Nowell, P.C., Croce, C.M. (1991) Cloning of ALL-1, the locus involved in leukemias with the t(4;11) (q21;q23), t(9;11) (p22;q23), and t(11;19) (q23;p13) chromosome translocations. Cancer Research, 51, 6712 6714.
- 19 Cimino, G., Rapanotti, M.C., Biondi, A., Elia, L., Lo Coco, F., Price, C.M., Rossi, V., Rivolta, A., Canaani, E., Croce, C.M., Mandelli, F., Greaves, M. (1997) Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias. Cancer Research, 57, 2879 2883.
- 20 Corral, J., Lavenir, I., Impey, H., Warren, A.J., Forster, A., Larson, T.A., Bell, S., McKenzie, A.N., King, G., Rabbitts, T.H. (1996) An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell, 85, 853 861.
- 21 Cortes, J., O'Brien, S., Kantarjian, H., Cork, A., Stass, S., Freireich, E.J., Keating, M., Pierce, S., Estey, E. (1994) Abnormalities in the long arm of chromosome 11(11q) in patients with de novo and secondary acute myelogenous leukemias and myelodysplastic syndromes. Leukemia, 8, 2174 2178.
- 22 Detourmignies, L., Castaigne, S., Stoppa, A.M., Harousseau, J.L., Sadoun, A., Janvier, M., Demory, J.L., Sanz, M., Berger, R., Bauters, F., Chomienne, C., Fenaux, P. (1992) Therapy-related acute promyelocytic leukemia: a report on 16 cases. Journal of Clinical Oncology, 10, 1430 1435.
- 23 DeVore, R., Whitlock, J., Hainsworth, J.D., Johnson, D.H. (1989) Therapy-related acute nonlymphocytic leukemia with monocytic features and rearrangement of chromosome 11q. Annals of Internal Medicine, 110, 740 742.
- 24 DiMartino, J.F. & Cleary, M.L. (1999) MLL rearrangements in haematological malignancies: lessons from clinical and biological studies. British Journal of Haematology, 106, 614 626.
- 25 Dissing, M., Le Beau, M.M., Pedersen-Bjergaard, J. (1998) Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: rare events related to DNA-topoisomerase II inhibitors? Journal of Clinical Oncology, 16, 1890 1896.
- 26 Djabali, M., Selleri, L., Parry, P., Bower, M., Young, B.D., Evans, G.A. (1992) A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nature Genetics, 2, 113 118.
- 27 Domer, P.H., Head, D.R., Renganathan, N., Raimondi, S.C., Yang, E., Atlas, M. (1995) Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11). Leukemia, 9, 1305 1312.
- 28 Downing, J.R. & Look, A.T. (1996) MLL fusion genes in the 11q23 acute leukemias. Cancer Treatment Research, 84, 73 92.
- 29 Felix, C.A., Walker, A.H., Lange, B.J., Williams, T.M., Winick, N.J., Cheung, N.K., Lovett, B.D., Nowell, P.C., Blair, I.A., Rebbeck, T.R. (1998) Association of CYP3A4 genotype with treatment-related leukemia. Proceedings of the National Academy of Sciences USA, 95, 13176 13181.
- 30 Felix, C.A., Winick, N.J., Negrini, M., Bowman, W.P., Croce, C.M., Lange, B.J. (1993) Common region of ALL-1 gene disrupted in epipodophyllotoxin- related secondary acute myeloid leukemia. Cancer Research, 53, 2954 2956.
- 31 Fidanza, V., Melotti, P., Yano, T., Nakamura, T., Bradley, A., Canaani, E., Calabretta, B., Croce, C.M. (1996) Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro. Cancer Research, 56, 1179 1183.
- 32 Fry, D.W. (1990) Cytotoxic synergism between trimetrexate and etoposide. Evidence that trimetrexate potentiates etoposide-induced protein-associated DNA strand breaks in L1210 leukemia cells through alterations in intracellular ATP concentrations. Biochemical Pharmacology, 40, 1981 1988.
- 33 Gill Super, H.J., Rothberg, P.G., Kobayashi, H., Freeman, A.I., Diaz, M.O., Rowley, J.D. (1994) Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23 . Blood, 83, 641 644.
- 34 Giralt, S., Estey, E., Albitar, M., Van Besien, K., Rondon, G., Anderlini, P., O'Brien, S., Khouri, I., Gajewski, J., Mehra, R., Claxton, D., Andersson, B., Beran, M., Przepiorka, D., Koller, C., Kornblau, S., Korbling, M., Keating, M., Kantarjian, H., Champlin, R., Korbling, M. (1997) Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy. Blood, 89, 4531 4536.
- 35 Gu, Y., Alder, H., Nakamura, T., Schichman, S.A., Prasad, R., Canaani, O., Saito, H., Croce, C.M., Canaani, E. (1994) Sequence analysis of the breakpoint cluster region in the ALL- 1 gene involved in acute leukemia. Cancer Research, 54, 2326 2330.
- 36 Gu, Y., Cimino, G., Alder, H., Nakamura, T., Prasad, R., Canaani, O., Moir, D.T., Jones, C., Nowell, P.C., Croce, C.M., Canaani, E. (1992b) The (4;11) (q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase. Proceedings of the National Academy of Sciences USA, 89, 10464 10468.
- 37 Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O., Cimino, G., Croce, C.M., Canaani, E. (1992a) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene . Cell, 71, 701 708.
- 38 Hale, G.A., Heslop, H.E., Bowman, L.C., Rochester, R.M., Pui, C.-H., Brenner, M.K., Krance, R.A. (1999) Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies. Bone Marrow Transplantation, 24, 735 739.
- 39
Haupt, R.,
Fears, T.R.,
Heise, A.,
Gadner, H.,
Loiacono, G.,
De Terlizzi, M.,
Tucker, M.A. (1997) Risk of secondary leukemia after treatment with etoposide (VP-16) for Langerhans' cell histiocytosis in Italian and Austrian–German populations.
International Journal of Cancer, 71, 9 13.
10.1002/(SICI)1097-0215(19970328)71:1<9::AID-IJC3>3.0.CO;2-Y CAS PubMed Web of Science® Google Scholar
- 40 Hawkins, M.M., Wilson, L.M., Stovall, M.A., Marsden, H.B., Potok, M.H., Kingston, J.E., Chessells, J.M. (1992) Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer. British Medical Journal, 304, 951 958.
- 41 Height, S.E., Dainton, M.G., Kearney, L., Swansbury, G.J., Matutes, E., Dyer, M.J.S., Treleaven, J.G., Powles, R.L., Catovsky, D. (1994) Acute myelomonocytic leukemia with t(10;11) (p13;q23): heterogeneity of breakpoints at 11q23 with recombinase activation. Genes, Chromosomes and Cancer, 11, 136 139.
- 42 Hess, J.L., Yu, B.D., Li, B., Hanson, R., Korsmeyer, S.J. (1997) Defects in yolk sac hematopoiesis in Mll-null embryos. Blood, 90, 1799 1806.
- 43 Heyn, R., Khan, F., Ensign, L.G., Donaldson, S.S., Ruymann, F., Smith, M.A., Vietti, T., Maurer, H.M. (1994) Acute myeloid leukemia in patients treated for rhabdomyosarcoma with cyclophosphamide and low-dose etoposide on Intergroup Rhabdomyosarcoma Study III: an interim report. Medical and Pediatric Oncology, 23, 99 106.
- 44
Horibe, K.,
Matsushita, T.,
Numata, S.,
Miyajima, Y.,
Katayama, I.,
Kitabayashi, T.,
Yanai, M.,
Sekiguchi, N.,
Egi, S. (1993) Acute promyelocytic leukemia with t(15;17) abnormality after chemotherapy containing etoposide for Langerhans cell histiocytosis.
Cancer, 72, 3723 3726.
10.1002/1097-0142(19931215)72:12<3723::AID-CNCR2820721226>3.0.CO;2-Y CAS PubMed Web of Science® Google Scholar
- 45 Hunger, S.P., Sklar, J., Link, M.P. (1992) Acute lymphoblastic leukemia occurring as a second malignant neoplasma in childhood: report three cases and review of the literature. Journal of Clinical Oncology, 10, 156 163.
- 46 James, S.J., Basknakian, A.G., Miller, B.J. (1994) In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Research, 54, 5075 5080.
- 47 Kakihara, T., Tanaka, A., Kataoka, S., Yamamoto, K., Okada, R., Watanabe, A., Uchiyama, M., Kishi, K. (1996) Differentiation induction therapy with all-trans retinoic acid (ATRA) in a patient with secondary 11q23 leukemia. Journal of Pediatric Hematology and Oncology, 18, 405 408.
- 48 Kollmannsberger, C., Beyer, J., Droz, J.P., Harstrick, A., Hartmann, J.T., Biron, P., Flechon, A., Schoffski, P., Kuczyk, M., Schmoll, H.J., Kanz, L., Bokemeyer, C. (1998) Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumors. Journal of Clinical Oncology, 16, 3386 3391.
- 49 Kudo, K., Yoshida, H., Kiyoi, H., Numata, S., Horibe, K., Naoe, T. (1998) Etoposide-related acute promyelocytic leukemia. Leukemia, 12, 1171 1175.
- 50 Kushner, B.H., Cheung, N.K., Kramer, K., Heller, G., Jhanwar, S.C. (1998) Neuroblastoma and treatment-related myelodysplasia/leukemia: the Memorial Sloan-Kettering experience and a literature review. Journal of Clinical Oncology, 16, 3880 3889.
- 51 Leahey, A.M., Friedman, D.L., Bunin, N. (1999) Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia. Bone Marrow Transplantation, 23, 21 25.
- 52 Malkin, D., Jolly, K.W., Barbier, N., Look, A.T., Friend, S.H., Gebhardt, M.C., Andersen, T.I., Borresen, A., Li, F.P., Garber, J., Strong, L.C. (1992) Germline mutation of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. New England Journal of Medicine, 336, 1309 1315.
- 53 Marcucci, G., Strout, M.P., Bloomfield, C.D., Caligiuri, M.A. (1998) Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: distinct origin of normal versus leukemic ALL1 fusion transcripts. Cancer Research, 58, 790 793.
- 54 Marty, M. (1993) Epirubicin and the risk of leukemia: not substantiated? International Collaborative Cancer Group Steering Committee. Journal of Clinical Oncology, 11, 1431 1433.
- 55 Matsuzaki, A., Inamitsu, T., Watanabe, T., Ohga, S., Ishii, E., Nagotoshi, Y., Tasaka, H., Suda, M., Ueda, K. (1994) Acute promyelocytic leukaemia in a patient treated with etoposide for Langerhans cell histiocytosis. British Journal of Haematology, 86, 887 889.
- 56 Matthews, D.C., Appelbaum, F.R., Eary, J.F., Fisher, D.R., Durack, L.D., Bush, S.A., Hui, T.E., Martin, P.J., Mitchell, D., Press, O.W. (1995) Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood, 85, 1122 1131.
- 57 Megonigal, M.D., Rappaport, E.F., Jones, D.H., Williams, T.M., Lovett, B.D., Kelly, K.M., Lerou, P.H., Moulton, T., Budarf, M.L., Felix, C.A. (1998a) t(11;22) (q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proceedings of the National Academy of Sciences USA, 95, 6413 6418.
- 58 Megonigal, M.D., Rappaport, E.F., Nowell, P.C., Lange, B.J., Felix, C.A. (1998b) Potential role for wild-type p53 in leukemias with MLL gene translocations. Oncogene, 16, 1351 1356.
- 59 Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R.P., Lange, B., Crist, W.M., Nowell, P.C., Croce, C.M., Canaani, E. (1993) Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proceedings of the National Academy of Sciences USA, 90, 4631 4635.
- 60 Naoe, T., Kudo, K., Yoshida, H., Horibe, K., Ohno, R. (1997) Molecular analysis of the t(15;17) translocation in de novo and secondary acute promyelocytic leukemia. Leukemia, 11, 287 288.
- 61 Negrini, M., Felix, C.A., Martin, C., Lange, B.J., Nakamura, T., Canaani, E., Croce, C.M. (1993) Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. Cancer Research, 53, 4489 4492.
- 62 Nichols, C.R., Breeden, E.S., Loehrer, P.J., Williams, S.D., Einhorn, L.H. (1993) Secondary leukemia associated with a conventional dose of etoposide: review of serial germ cell tumor protocols. Journal of the National Cancer Institute, 85, 36 40.
- 63
Nishiyama, M.,
Arai, Y.,
Tsunematsu, Y.,
Kobayashi, H.,
Asami, K.,
Yabe, M.,
Kato, S.,
Oda, M.,
Eguchi, H.,
Ohki, M.,
Kaneko, Y. (1999) 11p15 translocations involving NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome.
Genes, Chromosomes and Cancer, 26, 215 220.
10.1002/(SICI)1098-2264(199911)26:3<215::AID-GCC5>3.0.CO;2-1 CAS PubMed Web of Science® Google Scholar
- 64 Parry, P., Djabali, M., Bower, M., Khristich, J., Waterman, M., Gibbons, B., Young, B.D., Evans, G. (1993) Structure and expression of the human trithorax-like gene 1 involved in acute leukemias. Proceedings of the National Academy of Sciences USA, 90, 4738 4742.
- 65 Pedersen-Bjergaard, J., Brondum-Nielsen, K., Karle, H., Johansson, B. (1997) Chemotherapy-related — late occurring — Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors? Leukemia, 11, 1571 1574.
- 66 Pedersen-Bjergaard, J., Daugaard, G., Hansen, S.W., Philip, P., Larsen, S.O., Rorth, M. (1991) Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet, 338, 359 363.
- 67 Pedersen-Bjergaard, J., Johansson, B., Philip, P. (1994) Translocation (3;21) (q26;q22) in therapy-related myelodysplasia following drugs targeting DNA-topoisomerase II combined with alkylating agents, and in myeloproliferative disorders undergoing spontaneous leukemic transformation. Cancer Genetics and Cytogenetics, 76, 50 55.
- 68 Pedersen-Bjergaard, J., Philip, P., Larsen, S.O., Andersson, M., Daugaard, G., Ersboll, J., Hansen, S.W., Hou-Jensen, K., Nielsen, D., Sigsgaard, T.C., Specht, L., Osterlind, K. (1993) Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series. Leukemia, 7, 1975 1986.
- 69 Pedersen-Bjergaard, J., Philip, P., Larsen, S.O., Jensen, G., Byrsting, K. (1990) Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia. Blood, 76, 1083 1091.
- 70 Pedersen-Bjergaard, J. & Rowley, J.D. (1994) The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood, 83, 2780 2786.
- 71 Pedersen-Bjergaard, J., Sigsgaard, T.C., Nielsen, D., Gjedde, S.B., Philip, P., Hansen, M., Larsen, S.O., Rorth, M., Mouridsen, H., Dombernowsky, P., Rrth, M. (1992) Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer. Journal of Clinical Oncology, 10, 1444 1451.
- 72 Prasad, R., Yano, T., Sorio, C., Nakamura, T., Rallapalli, R., Gu, Y., Leshkowitz, D., Croce, C.M., Canaani, E. (1995) Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia. Proceedings of the National Academy of Sciences USA, 92, 12160 12164.
- 73 Pratt, C.B. & Pui, C.-H. (1992) Secondary acute lymphoblastic leukemia in childhood. Journal of Clinical Oncology, 10, 866.
- 74 Prieto, F., Palau, F., Badia, L., Beneyto, M., Perez-Sirvent, M.L., Orts, A., Castel, V. (1990) 11q23 abnormalities in children with acute nonlymphocytic leukemia (M4–M5). Association with previous chemotherapy. Cancer Genetics and Cytogenetics, 45, 1 11.
- 75 Pui, C.-H. (1991) Epipodophyllotoxin-related acute myeloid leukaemia. Lancet, 338, 1468.
- 76 Pui, C.-H. (1992) Acute leukemias with the t(4;11) (q21;q23). Leukemia and Lymphoma, 7, 173 179.
- 77 Pui, C.-H., Behm, F.G., Raimondi, S.C., Dodge, R.K., George, S.L., Rivera, G.K., MirroJ., Kalwinsky, D.K., Dahl, G.V., Murphy, S.B., Crist, W.M., Williams, D.L. (1989) Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. New England Journal of Medicine, 321, 136 142.
- 78 Pui, C.-H., Hancock, M.L., Raimondi, S.C., Head, D.R., Thompson, E., Wilimas, J., Kun, L.E., Bowman, L.C., Crist, W.M., Pratt, C.B. (1990) Myeloid neoplasia in children treated for solid tumours. Lancet, 336, 417 421.
- 79 Pui, C.-H., Relling, M.V., Rivera, G.K., Hancock, M.L., Raimondi, S.C., Heslop, H.E., Santana, V.M., Ribeiro, R.C., Sandlund, J.T., Mahmoud, H.H., Evans, W.E., Krance, R.A. (1995a) Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia, 9, 1990 1996.
- 80 Pui, C.H., Relling, M.V., Behm, F.G., Hancock, M.L., Boyett, J.M., Raimondi, S.C., Krance, R.A., Mahmoud, H.H., Ribeiro, R.C., Sandlund, J.T., Head, D.R., Evans, W.E. (1995b) L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins. Leukemia, 9, 1680 1684.
- 81 Pui, C.-H., Ribeiro, R.C., Hancock, M.L., Rivera, G.K., Evans, W.E., Raimondi, S.C., Head, D.R., Behm, F.G., Mahmoud, M.H., Sandlund, J.T., Crist, W. (1991) Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphocytic leukemia. New England Journal of Medicine, 325, 1682 1687.
- 82 Quesnel, B., Kantarjian, H., Bjergaard, J.P., Brault, P., Estey, E., Lai, J.L., Tilly, H., Stoppa, A.M., Archimbaud, E., Harousseau, J.L. (1993) Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature. Journal of Clinical Oncology, 11, 2370 2379.
- 83 Rasio, D., Schichman, S.A., Negrini, M., Canaani, E., Croce, C.M. (1996) Complete exon structure of the ALL1 gene. Cancer Research, 56, 1766 1769.
- 84 Ratain, M.J., Kaminer, L.S., Bitran, J.D., Larson, R.A., LeBeau, M.M., Skosey, C., Purl, S., Hoffman, P.C., Wade, J., Vardiman, J.W., Kaly, K., Rowley, J.D., Golomb, H.M. (1987) Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood, 70, 1412 1417.
- 85 Ratain, M.J. & Rowley, J.D. (1992) Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes. Annals of Oncology, 3, 107 111.
- 86 Relling, M.V., Yanishevski, Y., Nemec, J., Evans, W.E., Boyett, J.M., Behm, F.G., Pui, C.H. (1998) Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia, 12, 346 352.
- 87 Riggi, M. & Riva, A. (1993) Therapy-related leukemia: what is the role of 4-epi-doxorubicin? Journal of Clinical Oncology, 11, 1430 1431.
- 88 Ross, J.A., Potter, J.D., Robison, L.L. (1994) Infant leukemia, topoisomerase II inhibitors, and the MLL gene. Journal of the National Cancer Institute, 86, 1678 1680.
- 89 Rubnitz, J.E., Behm, F.G., Downing, J.R. (1996) 11q23 rearrangements in acute leukemia. Leukemia, 10, 74 82.
- 90
Sandler, E.S.,
Friedman, D.J.,
Mustafa, M.M.,
Winick, N.J.,
Bowman, W.P.,
Buchanan, G.R. (1997) Treatment of children with epipodophyllotoxin-induced secondary acute myeloid leukemia.
Cancer, 79, 1049 1054.
10.1002/(SICI)1097-0142(19970301)79:5<1049::AID-CNCR24>3.0.CO;2-0 PubMed Web of Science® Google Scholar
- 91 Sandoval, C., Pui, C.-H., Bowman, L.C., Heaton, D., Hurwitz, C.A., Raimondi, S.C., Behm, F.G., Head, D.R. (1993) Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. Journal of Clinical Oncology, 11, 1039 1045.
- 92 Santana, V.M., Hurwitz, C.A., Blakley, R.L., Crom, W.R., Luo, X., Roberts, W.M., Ribeiro, R., Mahmoud, H., Krance, R.A. (1994) Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia. Blood, 84, 1237 1242.
- 93 Schichman, S.A., Caligiuri, M.A., Strout, M.P., Carter, S.L., Gu, Y., Canaani, E., Bloomfield, C.D., Croce, C.M. (1994) ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements. Cancer Research, 54, 4277 4280.
- 94 Schnittger, S., Wormann, B., Hiddemann, W., Griesinger, F. (1998) Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors. Blood, 92, 1728 1734.
- 95 Secker-Walker, L.M., Moorman, A.V., Bain, B.J., Mehta, A.B. (1998) Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. Leukemia, 12, 840 844.
- 96 Smith, M.A., McCaffrey, R.P., Karp, J.E. (1996) The secondary leukemias: challenges and research directions. Journal of the National Cancer Institute, 88, 407 418.
- 97 Smith, M.A., Rubinstein, L., Anderson, J.R., Arthur, D., Catalano, P.J., Freidlin, B., Heyn, R., Khayat, A., Krailo, M., Land, V.J., Miser, J., Shuster, J., Vena, D. (1999) Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. Journal of Clinical Oncology, 17, 569 577.
- 98 Smith, M.A., Rubinstein, L., Ungerleider, R.S. (1995) Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks. Medical Pediatrics and Oncology, 23, 86 98.
- 99 So, C.W., Ma, Z.G., Price, C.M., Dong, S., Chen, S.J., Gu, L.J., So, C.K., Wiedemann, L.M., Chan, L.C. (1997) MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes. Cancer Research, 57, 117 122.
- 100 Stanulla, M., Wang, J., Chervinsky, D.S., Aplan, P.D. (1997a) Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. Leukemia, 11, 490 496.
- 101 Stanulla, M., Wang, J., Chervinsky, D.S., Thandla, S., Aplan, P.D. (1997b) DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Molecular & Cellular Biology, 17, 4070 4079.
- 102 Stanulla, M., Schunemann, H.J., Thandla, S., Brecher, M.L., Aplan, P.D. (1998) Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients. Molecular Pathology, 51, 85 89.
- 103 Stine, K.C., Saylors, R.L., Sawyer, J.R., Becton, D.L. (1997) Secondary acute myelogenous leukemia following safe exposure to etoposide. Journal of Clinical Oncology, 15, 1583 1586.
- 104 Strissel, P.L., Strick, R., Rowley, J.D., Zeleznik-Le, N.J. (1998) An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region. Blood, 92, 3793 3803.
- 105 Sugita, K., Furukawa, T., Tsuchida, M., Okawa, Y., Nakazawa, S., Akatsuka, J., Ohira, M., Nishimura, K. (1993) High frequency of etoposide-related secondary leukemia in children with non-Hodgkin's lymphoma. American Journal of Pediatric Hematology/Oncology, 15, 99 104.
- 106 Super, H.J., McCabe, N.R., Thirman, M.J., Larson, R.A., Le Beau, M.M., Pedersen-Bjergaard, J., Philip, P., Diaz, M.O., Rowley, J.D. (1993) Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood, 82, 3705 3711.
- 107
Super, H.G.,
Strissel, P.L.,
Sobulo, O.M.,
Burian, D.,
Reshmi, S.C.,
Roe, B.,
Zeleznik-Le, N.J.,
Diaz, M.O.,
Rowley, J.D. (1997) Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.
Genes, Chromosomes and Cancer, 20, 185 195.
10.1002/(SICI)1098-2264(199710)20:2<185::AID-GCC9>3.0.CO;2-# CAS PubMed Web of Science® Google Scholar
- 108 Thirman, M.J., Gill, H.J., Burnett, R.C., Mbangkollo, D., McCabe, N.R., Kobayashi, H., Ziemin-van der Poel, S., Kaneko, Y., Morgan, R., Sandberg, A.A., Chaganti, R.S.K., Larson, R.A., LeBeau, M.M., Diaz, M.O., Rowley, J.D. (1993) Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. New England Journal of Medicine, 329, 909 914.
- 109 Tkachuk, D.C., Kohler, S., Cleary, M.L. (1992) Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias . Cell, 71, 691 700.
- 110 Uckun, F.M., Herman-Hatten, K., Crotty, M.L., Sensel, M.G., Sather, H.N., Tuel-Ahlgren, L., Sarquis, M.B., Bostrom, B., Nachman, J.B., Steinherz, P.G., Gaynon, P.S., Heerema, N. (1998) Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11) (q21;q23) chromosomal translocation. Blood, 92, 810 821.
- 111 Verdeguer, A., Ruiz, J.G., Ferris, J., Esquembre, C., Tasso, M.J., Fernandez, J.M., Prieto, F., Castel, V. (1992) Acute nonlymphoblastic leukemia in children treated for acute lymphoblastic leukemia with an intensive regimen including teniposide. Medical and Pediatric Oncology, 20, 48 52.
- 112
Weisburger, E.K. (1977) Bioassay program for carcinogenic hazards of cancer chemotherapeutic agents.
Cancer, 40, 1935 1949.
10.1002/1097-0142(197710)40:4+<1935::AID-CNCR2820400827>3.0.CO;2-R CAS PubMed Web of Science® Google Scholar
- 113
Whitlock, J.A.,
Greer, J.P.,
Lukens, J.N. (1991) Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia.
Cancer, 68, 600 604.
10.1002/1097-0142(19910801)68:3<600::AID-CNCR2820680326>3.0.CO;2-F CAS PubMed Web of Science® Google Scholar
- 114 Winick, N.J., McKenna, R.W., Shuster, J.J., Schneider, N.R., Borowitz, M.J., Bowman, W.P., Jacaruso, D., Kamen, B.A., Buchanan, G.R. (1993) Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide. Journal of Clinical Oncology, 11, 209 217.
- 115 Woo, M.H., Shuster, J.J., Chen, C.-L., Bash, R.J., Behm, F.G., Camitta, B., Felix, C.A., Kamen, B.A., Pui, C.-H., Raimondi, S.C., Winick, N.J., Amylon, M.D., Relling, M.V. (2000) Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid neoplasias . Leukemia (in press).
- 116 Xue, Y., Lu, D., Guo, Y., Lin, B. (1992) Specific chromosomal translocations and therapy-related leukemia induced by bimolane therapy for psoriasis. Leukemia Research, 16, 1113 1123.
- 117 Yagita, M., Ieki, Y., Onishi, R., Huang, C.L., Adachi, M., Horiike, S., Konaka, Y., Taki, T., Miyake, M. (1998) Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer. International Journal of Oncology, 13, 91 96.
- 118 Yu, B.D., Hanson, R.D., Hess, J.L., Horning, S.E., Korsmeyer, S.J. (1998) MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proceedings of the National Academy of Sciences USA, 95, 10632 10636.
- 119 Yu, B.D., Hess, J.L., Horning, S.E., Brown, G.A., Korsmeyer, S.J. (1995) Altered Hox expression and segmental identity in Mll-mutant mice. Nature, 378, 505 508.
- 120 Zeleznik-Le, N.J., Harden, A.M., Rowley, J.D. (1994) 11q23 translocations split the ‘AT-hook’ cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proceedings of the National Academy of Sciences USA, 91, 10610 10614.
- 121 Ziemin-van der Poel, S., McCabe, N.R., Gill, H.J., EspinosaR., Patel, Y., Harden, A., Rubinelli, P., Smith, S.D., LeBeau, M.M., Rowley, J.D., Diaz, M.O. (1991) Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proceedings of the National Academy of Sciences USA, 88, 10735 10739.