Rosacea-like demodicidosis associated with acquired immunodeficiency syndrome
T. Jansen
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorU. Kastner
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorA. Kreuter
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorP. Altmeyer
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorT. Jansen
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorU. Kastner
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorA. Kreuter
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorP. Altmeyer
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
Search for more papers by this authorAbstract
We present a 35-year-old patient with acquired immunodeficiency syndrome who had demodicidosis on his face, characterized by multiple papules and papulopustules, associated pruritus, numerous mites on skin-surface biopsy and in biopsy specimens, and rapid response to topical treatment with permethrin. It seems likely that Demodex infestation does not manifest unless local or systemic immune function is altered, leading to the proliferation of the organism and subsequent disease.
References
- 1 Burns DA. Follicle mites and their role in disease. Clin Exp Dermatol 1992; 17: 552 – 5.
- 2 Aylesworth R & Vance JC. Demodex folliculorum and Demodex brevis in cutaneous biopsies. J Am Acad Dermatol 1982; 7: 583 – 9.
- 3 Roth AM. Demodex folliculorum in hair follicles of eyelid skin. Ann Ophthalmol 1979; 11: 37 – 40.
- 4 Kirk RW, (ed. ). Current Veterinary Therapy, Vol. 9. Philadelphia: W.B.Saunders, 1986; 531 – 4.
- 5 Grosshans E, Kremer M & Maleville J. Demodex folliculorum und die Histogenese der granulomatösen Rosazea. Hautarzt 1974; 25: 166 – 77.
- 6 Roihu T & Kariniemi AL. Demodex mites in acne rosacea. J Cutan Pathol 1998; 25: 550 – 2.
- 7 Rufli T, Mumcuoglu Y & Cajacob A et al. Demodex folliculorum: zur Ätiopathogenese und Therapie der Rosazea und der perioralen Dermatitis. Dermatologica 1981; 162: 12 – 26.
- 8 Purcell SM, Hayes TJ & Dixon SL. Pustular folliculitis associated with Demodex folliculorum. J Am Acad Dermatol 1986; 15: 1159 – 62.
- 9 Miskjian HG. Demodicidosis (Demodex infestation of the scalp). Arch Dermatol 1951; 63: 282 – 3.
- 10
Post CF &
Juhlin E.
Demodex folliculorum and blepharitis.
Arch Dermatol
1963; 88: 114
–
18.
10.1001/archderm.1963.01590210056008 Google Scholar
- 11 Fariña MC, Requena L & Sarasa JL et al. Spinulosis of the face as a manifestation of demodicidosis. Br J Dermatol 1998; 138: 901 – 3.
- 12 Ecker RI & Winkelmann RK. Demodex granuloma. Arch Dermatol 1979; 115: 343 – 4.
- 13 Ashack R, Frost M & Norins A. Papular pruritic eruption of Demodex folliculitis in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989; 21: 306 – 7.
- 14 Dominey A, Rosen T & Tschen J. Papulonodular demodicidosis associated with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989; 20: 197 – 201.
- 15 Bañuls J, Ramon D & Aniz E et al. Papular pruritic eruption with human immunodeficiency virus infection. Int J Dermatol 1991; 30: 801 – 3.
- 16 Mateo JR, Guzmán OS, Rubio EF & Franjo Fd. Demodex-attributed rosacea-like lesions in AIDS. Acta Derm Venereol (Stockh) 1993; 73: 437.
- 17 Barrio J, Lecona M & Heranz JM et al. Rosacea-like demodicidosis in an HIV-positive child. Dermatology 1996; 192: 143 – 5.
- 18 Sánchez-Viera M, Heranz JM & Sampelayo T et al. Granulomatous rosacea in a child infected with the human immunodeficiency virus. J Am Acad Dermatol 1992; 27: 1010 – 11.
- 19 Castanet J, Monpoux F & Mariani R et al. Demodicidosis in an immunodeficient child. Pediatr Dermatol 1997; 14: 219 – 20.
- 20 Ivy SP, Mackall CL & Gore L et al. Demodicidosis in childhood acute lymphoblastic leukemia: an opportunistic infection occurring with immunosuppression. J Pediatr 1995; 127: 751 – 4.
- 21 Sahn EE & Sheridan DM. Demodicidosis in a child with leukemia. J Am Acad Dermatol 1992; 27: 799 – 801.
- 22 Forton F & Seys B. Density of Demodex folliculorum in rosacea: a case–control study using standardized skin-surface biopsy. Br J Dermatol 1993; 128: 650 – 9.
- 23 Forton F, Seys B & Marchal JL. Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy. Br J Dermatol 1998; 138: 461 – 6.
- 24 Fearfield LA, Rowe A & Francis N et al. Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. Br J Dermatol 1999; 141: 3 – 11.DOI: 10.1046/j.1365-2133.1999.02914.x
- 25 Forstinger C, Kittler H & Binder M. Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. J Am Acad Dermatol 1999; 41: 775 – 7.
