Perspective
Tissue-resident macrophages — how to humanize our knowledge
Andreas Schlitzer,
Joachim L Schultze,
Andreas Schlitzer
Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany
Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
Search for more papers by this authorCorresponding Author
Joachim L Schultze
Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany
Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany
Professor JL Schultze, Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Carl Troll Strasse 31, 53115 Bonn, Germany. E-mail: [email protected]Search for more papers by this authorAndreas Schlitzer,
Joachim L Schultze,
Andreas Schlitzer
Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany
Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
Search for more papers by this authorCorresponding Author
Joachim L Schultze
Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany
Single Cell Genomics and Epigenomics Unit, German Center for Neurodegenerative Diseases, University of Bonn, Bonn, Germany
Professor JL Schultze, Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Carl Troll Strasse 31, 53115 Bonn, Germany. E-mail: [email protected]Search for more papers by this authorAbstract
Tissue macrophages of fetal and adult origin have pivotal roles in tissue homeostasis and organ inflammation. Recently several functional and transcriptomic studies have revealed their unique module-like transcriptomic organization leading to enormous tissue-dependent functional plasticity. In this review, we discuss the development, tissue adaption and function of resident murine and human macrophages. Finally, we discuss our limited knowledge on human tissue macrophages and provide our opinion on their relevance during disease and for clinical application. At last we discuss a path towards a better understanding of human tissue macrophage populations using state of the art transcriptomic and epigenetic techniques to enable understanding of these powerful tissue-resident phagocytes.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
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