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Contributions of an orthopteran to the understanding of neuronal pathfinding
DIEGO SANCHEZ,
MARIA D GANEORNINA,
MICHAEL J BASTIANI,
DIEGO SANCHEZ
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorMARIA D GANEORNINA
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorMICHAEL J BASTIANI
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorDIEGO SANCHEZ,
MARIA D GANEORNINA,
MICHAEL J BASTIANI,
DIEGO SANCHEZ
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorMARIA D GANEORNINA
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorMICHAEL J BASTIANI
Biology Department, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorCorrespondence: Michael J. Bastiani, Biology Department, University of Utah, Salt Lake City, UT 84112, USA.
Summary
During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specific interaction of receptors on the neuronal surface with molecular cues in the environment. We review the information obtained in an invertebrate model system, the grasshopper embryo, about the specific role of the cell surface in wiring the nervous system.
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