Coaggregation ability of Weissella cibaria isolates with Fusobacterium nucleatum and their adhesiveness to epithelial cells
Mi-Sun Kang
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
Search for more papers by this authorHee-Sam Na
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
Search for more papers by this authorCorresponding Author
Jong-Suk Oh
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
*Corresponding author. Tel.: +82 62 220 4134; fax: +82 62 228 7294., E-mail address: [email protected]Search for more papers by this authorMi-Sun Kang
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
Search for more papers by this authorHee-Sam Na
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
Search for more papers by this authorCorresponding Author
Jong-Suk Oh
Department of Microbiology and Immunology, School of Medicine, Chonnam National University, 5 Hak-Dong, Dong-Gu, Gwangju 501-746, Republic of Korea
*Corresponding author. Tel.: +82 62 220 4134; fax: +82 62 228 7294., E-mail address: [email protected]Search for more papers by this authorEdited by W. Wade
Abstract
In the present study, we evaluated the ability of Weissella cibaria isolated from the oral cavity to coaggregate with Fusobacterium nucleatum, and the adhesiveness of these strains to epithelial cells. W. cibaria efficiently coaggregated with F. nucleatum, and adhered to epithelial cells. We tested the effects of various factors on the coaggregation. The coaggregation and adhesiveness of W. cibaria disappeared upon exposure to pronase or LiCl, suggesting that proteinaceous components on the surface of W. cibaria mediated the coaggregation and adhesiveness. In conclusion, W. cibaria may serve as a potential probiotic with the ability to establish an oral flora protecting against oral pathogens.
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