REVIEW
Macrophage functions in wound healing
Malgorzata Kloc,
Rafik M. Ghobrial,
Jarek Wosik,
Aneta Lewicka,
Sławomir Lewicki,
Jacek Z. Kubiak,
Corresponding Author
Malgorzata Kloc
Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA
Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA
MD Anderson Cancer Center, University of Texas, Houston, Texas, USA
Correspondence
Malgorzata Kloc, The Houston Methodist Research Institute, Houston, Texas 77030, USA.
Email: [email protected]
Search for more papers by this authorRafik M. Ghobrial
Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA
Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA
Search for more papers by this authorJarek Wosik
Electrical and Computer Engineering Department, University of Houston, Houston, Texas, USA
Texas Center for Superconductivity, University of Houston, Houston, Texas, USA
Search for more papers by this authorAneta Lewicka
Laboratory of Epidemiology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Search for more papers by this authorSławomir Lewicki
Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Search for more papers by this authorJacek Z. Kubiak
Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Cell Cycle Group, Faculty of Medicine, Univ Rennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Rennes, France
Search for more papers by this authorMalgorzata Kloc,
Rafik M. Ghobrial,
Jarek Wosik,
Aneta Lewicka,
Sławomir Lewicki,
Jacek Z. Kubiak,
Corresponding Author
Malgorzata Kloc
Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA
Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA
MD Anderson Cancer Center, University of Texas, Houston, Texas, USA
Correspondence
Malgorzata Kloc, The Houston Methodist Research Institute, Houston, Texas 77030, USA.
Email: [email protected]
Search for more papers by this authorRafik M. Ghobrial
Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA
Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA
Search for more papers by this authorJarek Wosik
Electrical and Computer Engineering Department, University of Houston, Houston, Texas, USA
Texas Center for Superconductivity, University of Houston, Houston, Texas, USA
Search for more papers by this authorAneta Lewicka
Laboratory of Epidemiology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Search for more papers by this authorSławomir Lewicki
Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Search for more papers by this authorJacek Z. Kubiak
Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
Cell Cycle Group, Faculty of Medicine, Univ Rennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Rennes, France
Search for more papers by this authorAbstract
Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.
CONFLICTS OF INTEREST
The authors have declared that there is no conflict of interest.
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