Epidemiology
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An epidemiologic study of tracheoesophageal fistula and esophageal atresia in North Carolina
Carl D. Ozimek,
Roger C. Grimson,
Arthur S. Aylsworth,
Carl D. Ozimek
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorRoger C. Grimson
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorArthur S. Aylsworth
Department of Pediatrics and Biological Sciences Research Center, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorCarl D. Ozimek,
Roger C. Grimson,
Arthur S. Aylsworth,
Carl D. Ozimek
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorRoger C. Grimson
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorArthur S. Aylsworth
Department of Pediatrics and Biological Sciences Research Center, University of North Carolina, Chapel Hill, North Carolina 27514
Search for more papers by this authorAbstract
Two hundred and eighty-five cases of TEF/EA occurring in North Carolina from 1952–1978 were reviewed. Except for a greater incidence of low-birth-weight infants and hydramnios during pregnancy, the cases appeared to be representative of the population. Clustering of cases over time was statistically confirmed. The cyclic variation suggested an association with an infectious agent. The variation of reported infectious hepatitis cases during the period of this study resembled the variation of TEF/EA cases that had no other documented congenital malformations.
Literature Cited
- Aikat, B. K. and K. P. Sen Gupta (1956) Fetal and neonatal hepatitis. Indian J. Med. Sci. 10: 169–185.
- Babbott, J. G. and T. H. Ingalls (1961) Tracheoesophageal fistula occurring in Pennsylvania. Q. Rev. Pediatr. 16: 86–92.
- Babbott, J. G. and T. H. Ingalls (1962) Field studies of selected congenital malformations occurring in Pennsylvania. Am. J. Public Health, 52: 2009–2017.
- Bianchine, J. W., W. Burney, R. Moore, and L. Pavone (1976) Esophageal atresia with tracheoesophageal fistula in four male members of a kindred. South. Med. J. 69: 1098–1099.
- Calverly, R. K. and A. E. Johnston (1972) The anesthetic management of tracheo-oesophageal fistula: A review of ten years' expeience. Can. Anaesth. Soc. J. 19: 270–282.
- Center for Disease Control (1979) Temporal trends in the incidence of birth defects. Morbidity and Mortality Weekly Report 28: 401–403.
- Cozzi, F. and A. W. Wilkinson (1975) Low birth weight babies with oesophageal atresia or tracheo-oesophageal fistula. Arch. Dis. Childh. 50: 791–795.
- D'Cruz, I. A., S. G. Balani, and L. S. Iyer (1968) Infectious hepatitis and pregnancy. Obstet. Gynecol. 31: 449–455.
- Dennis, N. R., J. L. Nicholas, and I. Kovar (1973) Oesophageal atresia: 3 cases in 2 generations. Arch. Dis. Child. 48: 980–982.
- Ederer, F., M. H. Myers, and N. Mantel (1964) A statistical problem in space and time: Do leukemia cases come in clusters? Biometrics 20: 626–638.
- Engel, P. M. A., L. M. J. Vos, J. A. De Vries, and P. J. Kuijjer (1970) Esophageal atresia with tracheoesophageal fistula in mother and child. J. Pediatr. Surg. 5: 564–565.
- Fasting, H. and L. K. Winther (1978) Oesophageal atresia and tracheooesophageal fistula. Early and late results in 86 patients. Scand. J. Thorac. Cardiovasc. Surg. 12: 147–151.
- Freeman, M. G., W. L. Graves, and R. L. Thompson (1970) Indigent Negro and Caucasian birth weight-gestational age tables. Pediatrics 46: 9–15.
- Frost, O. (1976) Tracheooesophageal fistula associated with hormonal contraception during pregnancy. Br. Med. J. 2: 978.
- Grimson, R. C. (1979) Association of influenza with congenital tracheoesophageal fistula and esophageal atresia: An analysis of clusters, N.C. Dept. of Human Resources PHSB Studies 14: 1.
- Haight, C. and H. A. Towsley (1943) Congenital atresia of the esophagus with tracheoesophageal fistula: Extrapleural ligation of fistula and end to end anastomosis of esophageal segments. Surg. Gynecol. Obstet. 76: 672–688.
- Heiber, J. P., D. Dalton, J. Shorey, and B. Combes (1977) Hepatitis and pregnancy. J. Pediatr. 91: 545–549.
- Holden, M. P. and G. H. Wooler (1970) Tracheooesophageal fistula and oesophageal atresia: Results of 30 years' experience. Thorax 25: 406–412.
- Holder, T. M., D. T. Cloud, J. E. Lewis, Jr., and G. P. Pilling (1964) Esophageal atresia and tracheosophageal fistula: A survey of its members by the Surgical Section of the American Academy of Pediatrics. Pediatrics 34: 542–549.
- Jacobs, R. G. and E. M. Papper (1959) Anesthetic management of congenital atresia of the esophagus and tracheoesophageal fistula: A review of seven years experience and 72 cases. NY State J. Med. 59: 995–1002.
- King, S. L., R. L. Ladda, and S. J. Shochat (1977) Monozygotic twins concordant for tracheooesophageal fistula and discordant for the VATER association. Acta Paediatr. Scand. 66: 783–785.
- Knox, E. G. (1959) Secular pattern of congenital oesophageal atresia. Br. J. Prev. Soc. Med. 13: 222–226.
- Knox, E. G. (1971) Epidemics of rare diseases. Br. Med. Bull. 27: 43–47.
- Koop, C. E. (1971) Recent advances in the surgery of oesophageal atresia. Prog. Pediatr. Surg. 2: 41–56.
- Malkani, P. K. and A. L. Grewal (1957) Observations on infectious hepatitis in pregnancy. Indian J. Med. Res. 45(1 Suppl.) (). 77–84.
- Mansell, R. V. (1955) Infectious hepatitis in the first trimester of pregnancy and its effect on the fetus. Am. J. Obstet. Gynecol. 69: 1136–1139.
- Mantel, N., R. J. Kryscio, and M. H. Myers (1976) Tables and formulas for extended use of the Ederer-Myers-Mantel disease clustering procedure. Am. J. Epidemiol. 104: 576–584.
- Narayana Rao, A. V., C. Sita Devi, P. Svaithri, and E. Seshirekha (1969) Infectious hepatitis in pregnancy and puerperium-A study of 60 cases. Indian J. Med. Sci. 25: 471–478.
- NCCDMS (1950-1978) Communicable Disease Morbidity Statistics, 1950-1978, Published by the North Carolina Dept. of Human Resources.
- NCMCHS (1973, 1976) Maternal and Child Health Statistics, vol. 1, 1973 and 1976, p. 102-0-B, Published by the North Carolina Dept. of Human Resources.
- NCVS (1950-1978) North Carolina Vital Statistics, vol. Annual Reports, 1950-1978, Published by the North Carolina Dept. of Human Resources.
- Queenan, J. T. and E. Gadow (1970) Amniography for detection of congenital malformation. Obstet. Gynecol. 35: 648–657.
- Romsdahl, M. M., J. A. Hunter, and W. J. Grove (1966) Tracheoesophageal fistula and esophageal atresia: Surgical management and results at a university hospital. J. Thorac. Cardiovasc. Surg. 52: 571–578.
- Rothman, K. J. (1976) Detecting cyclic variation. Am. J. Epidemiol. 104: 585–586.
- Sall, J. P. (1979) SPECTRA procedure. In J. A. Helmig and K. A. Council (eds): SAS User's Guide. Raleigh, N.C.: SAS Institute, p. 381.
- Schimke, R. N., L. L. Leape, and T. M. Holder (1972) Familial occurrence of esophageal atresia: A preliminary report. Birth Defects Original Article Series VIII Williams and Williams, Baltimore, (2): 22–23. enpox, measles, mumps, and hepatitis: Results of a cohort study. JAMA 226:1521–1524.
- Slater, B. C. S., G. I. Watson, and J. C. McDonald (1964) Seasonal variation in congenital abnormalities. Preliminary report of a survey conducted by the Research Committee of the Council of the College of General Practitioners. Br. J. Prev. Soc. Med. 18: 1–7.
- Smith, E. I. (1957) The early development of the trachea and esophagus in relation to atresia of the esophagus and tracheoesophageal fistula. Contrib. Embryol. 36: 43–57.
- Stokes, J., I. J. Wolman, M. C. Blanchard, and J. D. Darquahr (1951) Viral hepatitis in the newborn. Clinical features, epidemiology and pathology. Am. J. Dis. Child. 82: 213–216.
- Strodel, W. E., A. G. Coran, M. M. Kirsh, W. H. Weintraub, J. R. Wesley, and H. Sloan (1979) Esophageal atresia: a 41-year experience. Arch. Surg. 114: 523–527.
- Wallenstein, S. (1980) A test for detection of clustering over time. Am. J. Epidemiol. 111: 367–372.
-
Waterston, D. J.,
R. E. B. Carter, and
E. Aberdeen
(1962)
Oesophageal atresia: Tracheooesophageal fistula. A study of survival in 218 infants.
Lancet
282: 819–822.
10.1016/S0140-6736(62)91837-8 Google Scholar
- Wayson, E. E., W. Garnjobst, J. J. Chandler, and C. G. Peterson (1965) Esophageal atresia with tracheoesophageal fistula: Lessons of a quarter century's experience. Am. J. Surg. 110: 162–167.
