Volume 7, Issue 1 2370002
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Strain Gradient Programming in 3D Fibrous Hydrogels to Direct Graded Cell Alignment (Small Methods 1/2023)

Avraham Kolel

Avraham Kolel

Department of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, 69978 Israel

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Bar Ergaz

Bar Ergaz

Department of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, 69978 Israel

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Shahar Goren

Shahar Goren

School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, 69978 Israel

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Oren Tchaicheeyan

Oren Tchaicheeyan

School of Mechanical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, 69978 Israel

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Ayelet Lesman

Ayelet Lesman

School of Mechanical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, 69978 Israel

Center for Physics and Chemistry of Living Systems, Tel Aviv University, Tel-Aviv, 69978 Israel

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First published: 17 January 2023

Graphical Abstract

Inside Front Cover

In article number 2201070, Lesman and co-workers use controlled geometry and external stretch to generate programmable gradients in strain and fiber alignment across 3D biological gels, leading to spatial controlled over cell alignment patterns. It provides a new technology for mechanobiology and tissue engineering applications.

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