Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment
First published: 08 August 2024
Graphical Abstract
Glioblastoma Treatment
In article number 2400081, Qianxue Chen, Xuan Xiao, Shenqi Zhang, and co-workers developed and validated a novel nanotechnology-based approach for glioblastoma treatment. They synthesized autocatalytic, brain tumor-targeting nanoparticles composed of self-assembled bardoxolone methyl. The resulting p28-LBM nanoparticles demonstrate remarkable capability in penetrating brain tumors and exhibit high efficacy in inhibiting glioblastoma growth. This approach represents a promising new avenue for improving outcomes in patients with glioblastoma.
