Borrow Strength to Exert: Low-Crystallinity Prussian Blue for Reduction Overload Enhanced Photothermal Therapy
Yuxin Yao
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorJunlie Yao
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Search for more papers by this authorShiyi Xiong
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorYabing Sun
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorLiangxue Lai
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorChenglong He
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorShaohua Jiang
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037 P. R. China
Search for more papers by this authorKareem Elsayad
Division of Anatomy, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, A-1090 Austria
Search for more papers by this authorCorresponding Author
Hao Peng
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAiguo Wu
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Search for more papers by this authorCorresponding Author
Fang Yang
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorYuxin Yao
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorJunlie Yao
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Search for more papers by this authorShiyi Xiong
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorYabing Sun
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorLiangxue Lai
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorChenglong He
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300 P. R. China
Search for more papers by this authorShaohua Jiang
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037 P. R. China
Search for more papers by this authorKareem Elsayad
Division of Anatomy, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, A-1090 Austria
Search for more papers by this authorCorresponding Author
Hao Peng
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAiguo Wu
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
Search for more papers by this authorCorresponding Author
Fang Yang
Cixi Institute of Biomedical Engineering, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Ningbo, 315201 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
The strategy “Borrow strength to exert” in Sun Tzu's Art of War refers to borrowing external forces to withstand the enemy. Inspired by this, applying this thought to cancer treatment can achieve a more efficient therapeutic effect. Therefore, a fulcrum to borrow the force is vital and significant. Compared with normal cells, tumor cells are more sensitive to redox stress owing to their abnormal redox metabolism. Herein, a regulatory protocol based on chloroauric acid (HAuCl4) is proposed to prepare small-size and low-crystallinity Prussian blue nanoparticles (LcPB NPs). Notably, LcPB NPs possess higher superoxide dismutase (SOD)-like enzyme activity to induce reduction overload and destroy metabolic processes and organelle functions, which leverages the redox status defect in tumors as the fulcrum. Due to the down-regulation of heat shock proteins (HSPs) mediated by redox imbalance, the inherent photothermal therapy (PTT) mode of LcPB NPs effectively inhibits tumor growth and disrupts calcium homeostasis. Additionally, LcPB NPs can improve the anticancer effect by inhibiting symbiotic bacteria. Meanwhile, their magnetic and optical response performance empowers magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) for tumor diagnosis. Therefore, this work executing the strategy “Borrowing strength to exert” by disturbing the redox balance represents a new antineoplastic paradigm.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
Supporting Information
| Filename | Description |
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| smll202406145-sup-0001-SuppMat.docx5.7 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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