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Dual Biosignal-Functional Injectable Microspheres for Remodeling Osteogenic Microenvironment (Small 36/2022)
Graphical Abstract
Bone Defect Treatment
Inspired by the concept of macrophage reprogramming, Wenguo Cui, Youcheng Yu, and co-workers construct immuno-engineering porous microspheres (IL-4/loaded liposomes (Ls)/poly (l-lactic acid) (PLLA)) to realize bone repair through the “physical” porous structure and “molecular” IL-4 chemokines dual signal regulation. The immuno-reprogramming IL-4/Ls/PLLA microspheres achieve the precise immuno-reprogramming of macrophages by driving the activation of the signaling pathways. This immune reengineering strategy paves the way for clinical bone defect treatment.
