Volume 18, Issue 20 202270100
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Supramolecular Core–Shell Nanoassemblies with Tumor Microenvironment-Triggered Size and Structure Switch for Improved Photothermal Therapy (Small 20/2022)

Ziyao Wang

Ziyao Wang

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Yanqiu Wang

Yanqiu Wang

School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009 P. R. China

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Xiaohuan Sun

Xiaohuan Sun

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Jinfeng Zhou

Jinfeng Zhou

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Xiaolin Chen

Xiaolin Chen

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Juqun Xi

Juqun Xi

School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009 P. R. China

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Lei Fan

Lei Fan

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Jie Han

Jie Han

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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Rong Guo

Rong Guo

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002 P. R. China

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First published: 19 May 2022

Graphical Abstract

Photothermal Therapy

In article number 2200588, Xiaohuan Sun, Jie Han, and co-workers construct size switchable core–shell nanostructures regulated by the tumor acidic microenvironment for benefits of both tumor accumulation and penetration. Superior photothermal performance of the core–shell nanostructures is achieved at the tumor site. The nanoplatform is demonstrated for improved antitumor efficacy.

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