Biointerfacing Antagonizing T-Cell Inhibitory Nanoparticles Potentiate Hepatocellular Carcinoma Checkpoint Blockade Therapy (Small 51/2021)
Han Wu
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorJia-Qi Zhu
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorXin-Fei Xu
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorHao Xing
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorMing-Da Wang
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorLei Liang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorChao Li
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorHang-Dong Jia
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorFeng Shen
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorDong-Sheng Huang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorTian Yang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorHan Wu
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorJia-Qi Zhu
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorXin-Fei Xu
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorHao Xing
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorMing-Da Wang
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorLei Liang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorChao Li
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorHang-Dong Jia
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorFeng Shen
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Search for more papers by this authorDong-Sheng Huang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorTian Yang
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014 China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310014 China
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200438 China
Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorGraphical Abstract
Biointerfacing Nanoparticles
In article number 2105237, Dong-Sheng Huang, Tian Yang, and co-workers develop a strategy of targeting therapeutic nanoparticles effectively reversing the immune-inhibiting microenvironment for enhanced PD-L1 checkpoint combination therapy. The platelet membrane cloaked nanoparticles activate the CD8+ T lymphocytes and antigen presentation of dendritic cells as well as the polarization of M1-type macrophages with the application of TIM-3 antibodies. With the collagen deposition, starvation therapy can enhance the efficacy of immunotherapy under a hypoxic microenvironment.
