Volume 16, Issue 31 2070174
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Cancer Therapy: A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy (Small 31/2020)

Yuxin Guo

Yuxin Guo

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Hao-Ran Jia

Hao-Ran Jia

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Xiaodong Zhang

Xiaodong Zhang

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Xinping Zhang

Xinping Zhang

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Qing Sun

Qing Sun

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Shao-Zhe Wang

Shao-Zhe Wang

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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Jing Zhao

Jing Zhao

Institute of Neurobiology, School of Medicine, Southeast University, Nanjing, 210096 P. R. China

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Fu-Gen Wu

Fu-Gen Wu

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 P. R. China

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First published: 06 August 2020

Graphical Abstract

Sustainable and cascade anticancer strategies have attracted great attention due to their excellent therapeutic performance. In article number 2000897, Fu-Gen Wu and co-workers present a self-amplified nanoreactor for cancer treatment. The nanoreactor can convert oxygen into HO• for chemodynamic therapy, consume glucose for starvation therapy, and provide a hypoxic environment for hypoxia-activated chemotherapy.

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