Volume 14, Issue 40 1870185
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Fluorescence-Activated Cell Sorters: Standing Surface Acoustic Wave (SSAW)-Based Fluorescence-Activated Cell Sorter (Small 40/2018)

Liqiang Ren

Liqiang Ren

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802 USA

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Shujie Yang

Shujie Yang

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708 USA

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Peiran Zhang

Peiran Zhang

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708 USA

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Zhiguo Qu

Zhiguo Qu

Key Laboratory of Thermo-Fluid Science and Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049 China

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Zhangming Mao

Zhangming Mao

Ascent Bio-Nano Technologies, Inc., Research Triangle Park, NC, 27709 USA

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Po-Hsun Huang

Po-Hsun Huang

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708 USA

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Yuchao Chen

Yuchao Chen

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802 USA

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Mengxi Wu

Mengxi Wu

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708 USA

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Lin Wang

Lin Wang

Ascent Bio-Nano Technologies, Inc., Research Triangle Park, NC, 27709 USA

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Peng Li

Peng Li

C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506 USA

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Tony Jun Huang

Tony Jun Huang

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27708 USA

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First published: 04 October 2018
Citations: 2

Graphical Abstract

In article number 1801996, Zhiguo Qu, Tony Jun Huang, and co-workers develop an acoustic-based fluorescence-activated cell sorter (FACS), in which cells are focused and deflected by standing surface acoustic waves, and are detected with an in-plane optical fiber system. The cell-focusing, cell-detection, and cell-deflection units of the FACS are integrated onto a small chip and work cooperatively to sort mammalian cells with high throughput and biocompatibility.

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