Notch Ligand Presenting Acellular 3D Microenvironments for ex vivo Human Hematopoietic Stem-Cell Culture made by Layer-By-Layer Assembly†
Jungwoo Lee
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA)
Search for more papers by this authorCorresponding Author
Nicholas A. Kotov
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA)
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA).Search for more papers by this authorJungwoo Lee
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA)
Search for more papers by this authorCorresponding Author
Nicholas A. Kotov
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA)
Departments of Biomedical Engineering, Chemical Engineering, and Material Science & Engineering University of Michigan 3074 H. H. Dow Building 2300 Hayward Street Ann Arbor, MI 48109 (USA).Search for more papers by this authorAuthors thank Prof. Irwin Bernstein for his valuable comments on the manuscript and acknowledge the staff of the Electron Microscopy Analysis Laboratory.
Graphical Abstract
Notch ligands presenting artificial 3D thymic microenvironments are created on ICC scaffolds utilizing a layer-by-layer molecular assembly technique (see image). A multicomponent LBL film substitutes the function of thymic stromal cells and successfully supports ex vivo T-cell differentiation of human hematopoietic stem cells.
Supporting Information
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