Research Article

Comparative study of two Ginkgo biloba extracts on the phagocytic activity and DTH response of healthy mice

Corresponding Author

María Martha Villaseñor-García

[email protected]

Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico

Centro de Investigación Biomédica de Occidente, IMSS, Sierra Mojada 800, Colonia Independencia S.L., 44340 Guadalajara, Jalisco, MexicoSearch for more papers by this author

Ana María Puebla-Pérez,

Ana María Puebla-Pérez

Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico

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Xavier Lozoya,

Xavier Lozoya

Medicinal Plants Laboratory, Research Unit of Neurological Diseases, National Medical Centre ‘Siglo XXI’, IMSS, Mexico City, Mexico

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María Martha Villaseñor-García,

Corresponding Author

María Martha Villaseñor-García

[email protected]

Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico

Centro de Investigación Biomédica de Occidente, IMSS, Sierra Mojada 800, Colonia Independencia S.L., 44340 Guadalajara, Jalisco, MexicoSearch for more papers by this author

Ana María Puebla-Pérez,

Ana María Puebla-Pérez

Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico

Search for more papers by this author

Xavier Lozoya,

Xavier Lozoya

Medicinal Plants Laboratory, Research Unit of Neurological Diseases, National Medical Centre ‘Siglo XXI’, IMSS, Mexico City, Mexico

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First published: 15 May 2002

https://doi.org/10.1002/ptr.850

Citations: 1

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Abstract

The phagocytic activity and delayed-type Hypersensitivity (DTH) response to dinitrofluorobenzene (DNFB) of healthy BALB/c mice treated orally (100 mg/kg/day for 7 days) using two Ginkgo biloba extracts were studied. The phytopharmaceuticals Gb 30 (Alban Muller International, France) and EGb 761 (Schwabe, Germany) administered orally stimulated the phagocytic activity of peritoneal and alveolar macrophages. Likewise, the DTH response was found to be increased only with Gb 30 treatment. These results suggest that Ginkgo biloba possesses immunological activity in addition to the biological activity reported. The different chemical concentration of the components of the Ginkgo biloba extracts mentioned above may be responsible for the differences in the observed findings. Copyright © 2002 John Wiley & Sons, Ltd.

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Volume16, Issue3

May 2002

Pages 253-255

Comparative study of two Ginkgo biloba extracts on the phagocytic activity and DTH response of healthy mice

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Comparative study of two Ginkgo biloba extracts on the phagocytic activity and DTH response of healthy mice

Abstract

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