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Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats

Corresponding Author

A. M. Salah

National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA

National Center for Natural Product Research, School of Pharmacy, University of Mississippi, University, MS 38677, USASearch for more papers by this author

J. Gathumbi,

J. Gathumbi

Institute of Veterinary Medicine, University of Munich, Munich, Germany

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W. Vierling,

W. Vierling

Institute of Pharmacology and Toxicology, Technical University of Munich, Munich, Germany

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A. M. Salah,

Corresponding Author

A. M. Salah

National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA

National Center for Natural Product Research, School of Pharmacy, University of Mississippi, University, MS 38677, USASearch for more papers by this author

J. Gathumbi,

J. Gathumbi

Institute of Veterinary Medicine, University of Munich, Munich, Germany

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W. Vierling,

W. Vierling

Institute of Pharmacology and Toxicology, Technical University of Munich, Munich, Germany

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First published: 15 May 2002

https://doi.org/10.1002/ptr.846

Citations: 33

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Abstract

The methanol extracts of Hibiscus sabdariffa (p < 0.01) showed a significant dose dependent relaxant effect (IC₅₀ = 350 μM) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly (p < 0.05–0.01) reduced the intestinal transit (13%–35%) in rats (IC₅₀ = 250 μM). The extracts (40% ± 04%) and nifedipin (51% ± 05%) also potentiated the diarrhoea inducing effect of castor oil (IC₅₀ = 350 μM). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca²⁺ channel modulated mode of action. Copyright © 2002 John Wiley & Sons, Ltd.

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Volume16, Issue3

May 2002

Pages 283-285

Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats

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Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats

Abstract

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