Phytochemicals targeting ferroptosis in cardiovascular diseases: Recent advances and therapeutic perspectives
Jianxia Wen
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Conceptualization, Funding acquisition, Methodology, Project administration, Software, Writing - original draft
Search for more papers by this authorLu Li
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Investigation, Visualization
Search for more papers by this authorYi Yang
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Resources, Validation
Search for more papers by this authorDinglin Ou
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Methodology
Search for more papers by this authorJunjie Yang
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Formal analysis
Search for more papers by this authorJiachen Xie
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Data curation
Search for more papers by this authorCorresponding Author
Wenya Du
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Correspondence
Wenya Du, School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China.
Email: [email protected]
Yuling Tong, School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China.
Email: [email protected]
Contribution: Supervision, Visualization
Search for more papers by this authorCorresponding Author
Yuling Tong
School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China
Correspondence
Wenya Du, School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China.
Email: [email protected]
Yuling Tong, School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China.
Email: [email protected]
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorJianxia Wen
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Conceptualization, Funding acquisition, Methodology, Project administration, Software, Writing - original draft
Search for more papers by this authorLu Li
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Investigation, Visualization
Search for more papers by this authorYi Yang
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Resources, Validation
Search for more papers by this authorDinglin Ou
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Methodology
Search for more papers by this authorJunjie Yang
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Formal analysis
Search for more papers by this authorJiachen Xie
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Contribution: Data curation
Search for more papers by this authorCorresponding Author
Wenya Du
School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China
Correspondence
Wenya Du, School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China.
Email: [email protected]
Yuling Tong, School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China.
Email: [email protected]
Contribution: Supervision, Visualization
Search for more papers by this authorCorresponding Author
Yuling Tong
School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China
Correspondence
Wenya Du, School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Chongqing Key Laboratory of Sichuan Chongqing Joint Construction of Specialty Food, Xihua University, Chengdu, China.
Email: [email protected]
Yuling Tong, School of Medicine and Food, Sichuan Vocational College of Health and Rehabilitation, Zigong, China.
Email: [email protected]
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorAbstract
Ferroptosis is a form of iron-dependent regulatory cell death that is related to the pathogenesis and progression of various cardiovascular diseases, such as arrhythmia, diabetic cardiomyopathy, myocardial infarction, myocardial ischemia/reperfusion injury, and heart failure. This makes it a promising therapeutic target for cardiovascular diseases. It is interesting that a significant number of cardiovascular disease treatment drugs derived from phytochemicals have been shown to target ferroptosis, thus producing cardioprotective effects. This study offers a concise overview of the initiation and control mechanisms of ferroptosis. It discusses the core regulatory factors of ferroptosis as potential new therapeutic targets for various cardiovascular diseases, elucidating how ferroptosis influences the progression of cardiovascular diseases. In addition, this review systematically summarizes the regulatory effects of phytochemicals on ferroptosis, emphasizing their potential mechanisms and clinical applications in treating cardiovascular diseases. This study provides a reference for further elucidating the molecular mechanisms of phytochemicals in treating cardiovascular diseases. This may accelerate their application in the treatment of cardiovascular diseases and is worth further research in this field.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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