Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies
Elena Azzini
Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy
Contribution: Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorSheila I. Peña-Corona
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Contribution: Data curation, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorHéctor Hernández-Parra
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorDeepak Chandran
Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, India
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorLejaniya Abdul Kalam Saleena
Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorYousef Sawikr
Department of Pharmacology and Toxicology, Faculty of Medicine University of Ajdabiya, Ajdabiya, Libya
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorIlaria Peluso
Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorSangram Dhumal
Division of Horticulture, RCSM College of Agriculture, Kolhapur, India
Contribution: Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorManoj Kumar
Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai, India
Contribution: Data curation, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Gerardo Leyva-Gómez
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Miquel Martorell
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Javad Sharifi-Rad
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Daniela Calina
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorElena Azzini
Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy
Contribution: Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorSheila I. Peña-Corona
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Contribution: Data curation, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorHéctor Hernández-Parra
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorDeepak Chandran
Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, India
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorLejaniya Abdul Kalam Saleena
Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorYousef Sawikr
Department of Pharmacology and Toxicology, Faculty of Medicine University of Ajdabiya, Ajdabiya, Libya
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorIlaria Peluso
Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy
Contribution: Data curation, Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorSangram Dhumal
Division of Horticulture, RCSM College of Agriculture, Kolhapur, India
Contribution: Investigation, Writing - original draft, Writing - review & editing
Search for more papers by this authorManoj Kumar
Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai, India
Contribution: Data curation, Investigation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Gerardo Leyva-Gómez
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Miquel Martorell
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Javad Sharifi-Rad
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Daniela Calina
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Correspondence
Gerardo Leyva-Gómez, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Email: [email protected]
Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Email: [email protected]
Javad Sharifi-Rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Email: [email protected]
Daniela Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Email: [email protected]
Contribution: Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorAbstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, a polyphenolic compound derived from Curcuma longa, has shown potential neuroprotective effects due to its anti-inflammatory and antioxidant properties. This review aims to synthesize current preclinical data on the anti-neuroinflammatory mechanisms of curcumin in the context of AD, addressing its pharmacokinetics, bioavailability, and potential as a therapeutic adjunct. An exhaustive literature search was conducted, focusing on recent studies within the last 10 years related to curcumin's impact on neuroinflammation and its neuroprotective role in AD. The review methodology included sourcing articles from specialized databases using specific medical subject headings terms to ensure precision and relevance. Curcumin demonstrates significant neuroprotective properties by modulating neuroinflammatory pathways, scavenging reactive oxygen species, and inhibiting the production of pro-inflammatory cytokines. Despite its potential, challenges remain regarding its limited bioavailability and the scarcity of comprehensive human clinical trials. Curcumin emerges as a promising therapeutic adjunct in AD due to its multimodal neuroprotective benefits. However, further research is required to overcome challenges related to bioavailability and to establish effective dosing regimens in human subjects. Developing novel delivery systems and formulations may enhance curcumin's therapeutic potential in AD treatment.
CONFLICT OF INTEREST STATEMENT
The authors wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Open Research
DATA AVAILABILITY STATEMENT
None.
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