Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review
Sepideh Yadegar
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Conceptualization, Data curation, Methodology, Writing - original draft
Search for more papers by this authorFatemeh Mohammadi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation, Methodology, Writing - original draft
Search for more papers by this authorAmirhossein Yadegar
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Conceptualization, Data curation, Methodology, Writing - original draft
Search for more papers by this authorAli Mohammadi Naeini
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorAryan Ayati
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorNesa Milan
Center for Orthopedic Trans-disciplinary Applied Research (COTAR), Shariaty Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorAmirhossein Tayebi
Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran
Contribution: Data curation
Search for more papers by this authorSeyed Arsalan Seyedi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorSeyed Ali Nabipoorashrafi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorSoghra Rabizadeh
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Writing - review & editing
Search for more papers by this authorAlireza Esteghamati
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Manouchehr Nakhjavani
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Correspondence
Manouchehr Nakhjavani, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Contribution: Conceptualization, Project administration, Supervision, Writing - review & editing
Search for more papers by this authorSepideh Yadegar
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Conceptualization, Data curation, Methodology, Writing - original draft
Search for more papers by this authorFatemeh Mohammadi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation, Methodology, Writing - original draft
Search for more papers by this authorAmirhossein Yadegar
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Conceptualization, Data curation, Methodology, Writing - original draft
Search for more papers by this authorAli Mohammadi Naeini
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorAryan Ayati
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorNesa Milan
Center for Orthopedic Trans-disciplinary Applied Research (COTAR), Shariaty Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorAmirhossein Tayebi
Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran
Contribution: Data curation
Search for more papers by this authorSeyed Arsalan Seyedi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorSeyed Ali Nabipoorashrafi
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Data curation
Search for more papers by this authorSoghra Rabizadeh
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Writing - review & editing
Search for more papers by this authorAlireza Esteghamati
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Manouchehr Nakhjavani
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Correspondence
Manouchehr Nakhjavani, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Email: [email protected]
Contribution: Conceptualization, Project administration, Supervision, Writing - review & editing
Search for more papers by this authorAbstract
Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs.
CONFLICT OF INTEREST STATEMENT
The authors declare no competing interests.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Supporting Information
| Filename | Description |
|---|---|
| ptr8171-sup-0001-TableS1.docxWord 2007 document , 18.6 KB | TABLE S1. Search strategy of PubMed, Web of Science, and Scopus. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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