REVIEW
Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain
Bárbara B. Garrido-Suárez,
Gabino Garrido,
Octavio Piñeros,
René Delgado-Hernández,
Corresponding Author
Bárbara B. Garrido-Suárez
Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, Cuba
Correspondence
Bárbara B. Garrido-Suárez, Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba.
Email: [email protected]
Gabino Garrido, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Gabino Garrido
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile
Correspondence
Bárbara B. Garrido-Suárez, Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba.
Email: [email protected]
Gabino Garrido, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile.
Email: [email protected]
Search for more papers by this authorOctavio Piñeros
Departamento de Investigaciones, Universidad de Santiago de Cali, Cali, Colombia
Search for more papers by this authorRené Delgado-Hernández
Centro de Estudio para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de La Habana, Havana, Cuba
Search for more papers by this authorBárbara B. Garrido-Suárez,
Gabino Garrido,
Octavio Piñeros,
René Delgado-Hernández,
Corresponding Author
Bárbara B. Garrido-Suárez
Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, Cuba
Correspondence
Bárbara B. Garrido-Suárez, Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba.
Email: [email protected]
Gabino Garrido, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Gabino Garrido
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile
Correspondence
Bárbara B. Garrido-Suárez, Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba.
Email: [email protected]
Gabino Garrido, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, Chile.
Email: [email protected]
Search for more papers by this authorOctavio Piñeros
Departamento de Investigaciones, Universidad de Santiago de Cali, Cali, Colombia
Search for more papers by this authorRené Delgado-Hernández
Centro de Estudio para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de La Habana, Havana, Cuba
Search for more papers by this authorAbstract
Osteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as Mangifera indica L. Previous studies have documented its analgesic, anti-inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.
CONFLICT OF INTEREST
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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