Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-κB and AP-1
Sun Hong Park
Collage of Pharmacy, Chungnam National University, Daejeon, Korea
These authors contributed equally to this work.
Search for more papers by this authorJong Soon Kang
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
These authors contributed equally to this work.
Search for more papers by this authorYeo Dae Yoon
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKiho Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKang-Jeon Kim
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKi Hoon Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorChang Woo Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorEun-Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
Search for more papers by this authorSang-Bae Han
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
Search for more papers by this authorBong Hee Kim
Collage of Pharmacy, Chungnam National University, Daejeon, Korea
Search for more papers by this authorCorresponding Author
Hwan Mook Kim
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, KoreaSearch for more papers by this authorCorresponding Author
Song-Kyu Park
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, KoreaSearch for more papers by this authorSun Hong Park
Collage of Pharmacy, Chungnam National University, Daejeon, Korea
These authors contributed equally to this work.
Search for more papers by this authorJong Soon Kang
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
These authors contributed equally to this work.
Search for more papers by this authorYeo Dae Yoon
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKiho Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKang-Jeon Kim
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorKi Hoon Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorChang Woo Lee
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Search for more papers by this authorEun-Yi Moon
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
Search for more papers by this authorSang-Bae Han
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
Search for more papers by this authorBong Hee Kim
Collage of Pharmacy, Chungnam National University, Daejeon, Korea
Search for more papers by this authorCorresponding Author
Hwan Mook Kim
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, KoreaSearch for more papers by this authorCorresponding Author
Song-Kyu Park
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, KoreaSearch for more papers by this authorAbstract
Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and cardiovascular protective activities. The present study reports an inhibitory effect of glabridin on microglial activation. Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor-α and interleukin-1β, in BV-2 cells, a murine microglia cell line. Moreover, mRNA expression of these inflammatory mediators was also suppressed by glabridin in LPS-stimulated BV-2 cells. Further study demonstrated that glabridin inhibited LPS-induced DNA binding activity of NF-κB and AP-1 in BV-2 cells. Collectively, the results presented in this report demonstrate that glabridin inhibits the production of inflammatory mediators in BV-2 cells and this is mediated, at least in part, by blocking NF-κB and AP-1 activation. The results suggest that glabridin might be a potential therapeutic agent for the treatment of neuroinflammatory and neurodegenerative diseases. Copyright © 2009 John Wiley & Sons, Ltd.
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