Volume 16, Issue 3 pp. 217-222

Research Article

Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model

Yoshimasa Kasahara,

Yoshimasa Kasahara

The Yamagata Prefectural Institute of Public Health, 1-6-6, Tokamachi, Yamagata-shi, Yamagata, 990-0031, Japan

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Ken Yasukawa,

Corresponding Author

Ken Yasukawa

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, Japan

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, JapanSearch for more papers by this author

Susumu Kitanaka,

Susumu Kitanaka

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, Japan

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M. Taufiq Khan,

M. Taufiq Khan

The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK

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Fred J. Evans,

Fred J. Evans

The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK

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Yoshimasa Kasahara,

Yoshimasa Kasahara

The Yamagata Prefectural Institute of Public Health, 1-6-6, Tokamachi, Yamagata-shi, Yamagata, 990-0031, Japan

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Ken Yasukawa,

Corresponding Author

Ken Yasukawa

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, Japan

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, JapanSearch for more papers by this author

Susumu Kitanaka,

Susumu Kitanaka

College of Pharmacy, Nihon University, 7-1, Narashinodai 7-chome, Funabashi-shi, Chiba 274-8555, Japan

Search for more papers by this author

M. Taufiq Khan,

M. Taufiq Khan

The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK

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Fred J. Evans,

Fred J. Evans

The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK

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First published: 15 May 2002

https://doi.org/10.1002/ptr.1099

Citations: 18

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Abstract

The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind-paw oedema induced by γ-carrageenin in mice. Furthermore, MEFTP not only inhibited the hind-paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E₁, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd.

REFERENCES

Akihisa T, Oinuma H, Tamura T et al. 1994. erythro-Hentriacontane-6,8-diol and 11 other alkane-6,8-diols from Carthamus tinctorius. Phytochemistry 36: 105–108.
10.1016/S0031-9422(00)97021-3
CAS Web of Science® Google Scholar
Bhardwaj DK, Bisht MS, Uain SC, Mehta CK, Sharma GC. 1980. Quercetagetin 5-methyl ether from the petals of Tagetes patula. Phytochemistry 19: 713–714.
10.1016/0031-9422(80)87053-1
CAS Web of Science® Google Scholar
Bown D. 1995. Encyclopedia of Herbs and Their Uses. Dorling Kindersley Ltd: London, 358–359.
Google Scholar
Bye RA Jr. 1986. Medical plants of the Sierra Madre: comparative study of Tarahumara and Mexican market plants. Econ Bot 40: 103–124.
10.1007/BF02858951
Web of Science® Google Scholar
Chandhoke N, Ghatak BJ. 1969. Studies on Tagetes minuta: some pharmacological actions of the essential oil. Indian J Med Res 57: 864–876.
CAS PubMed Web of Science® Google Scholar
Fujimura H, Tsuruni S, Hayashi M et al. 1963. Pharmacological studies on 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydro-pyrimidine (BCP) as an anti-inflammatory agent. Nippon Yakurigaku Zasshi 63: 43–86.
10.1254/fpj.63.43
Google Scholar
Garg SN, Charles R, Kumar S. 1999. A new acyclic monoterpene glucoside from the capitula of Tagetes patula. Fitoterapia 70: 472–474.
10.1016/S0367-326X(99)00044-1
CAS Web of Science® Google Scholar
Hasegawa I. 1978. Mechanism of adjuvant induced arthritis. Nihon Seikeigeka Gakkaishi 52: 1639–1651.
Google Scholar
Kasahara Y, Kumaki K, Katagiri S. 1991. Pharmacological studies on flower petals of Carthamus tinctorius. (II) Anti-inflammatory effect. Shoyakugaku Zasshi 45: 306–315.
Google Scholar
Kasahara Y, Kumaki K, Katagiri S et al., 1994. Carthami Flos and its component, stigmasterol, inhibit tumour promotion in mouse skin two-stage carcinogenesis. Phytother Res, 8: 327–331.
10.1002/ptr.2650080603
CAS Web of Science® Google Scholar
Kasahara Y, Kumaki K, Sato T, Katagiri S. 1989. Pharmacological studies on flower petals of Carthamus tinctorius. Central actions and anti-inflammation. Shoyakugaku Zasshi 43: 331–338.
Google Scholar
Khan MT. 1996. The podiatric treatment of hallux abducto valgus and its associated condition, bunion, with Tagetes patula. J Pharm Pharmacol 48: 768–770.
10.1111/j.2042-7158.1996.tb03968.x
CAS PubMed Web of Science® Google Scholar
Khan MT, Potter M, Birch I. 1996. Podiatric treatment of hyperkeratotic plantar lesions with marigold Tagetes erecta. Phytother Res 10: 211–214.
10.1002/(SICI)1099-1573(199605)10:3<211::AID-PTR813>3.0.CO;2-7
Web of Science® Google Scholar
Matsuda R, Tanihata S. 1992. Suppressive effect of sialic acid on the prostaglandin E₂-mediated oedema in carrageenin-induced inflammation of rat hind paws. Nippon Yakurigaku Zasshi 99: 363–372.
10.1254/fpj.99.363
CAS PubMed Web of Science® Google Scholar
Newbould BB. 1963. Chemotherapy of arthritis induced in rats mycobacterial adjuvant. Br J Pharmacol 21: 127–136.
10.1111/j.1476-5381.1963.tb01508.x
CAS PubMed Web of Science® Google Scholar
Quackenbush FW. 1973. Use of heat to saponify xanthophyll esters and speed analysis for carotenoids in feed material: collaborative study. J Assoc Anal Chem 56: 748–753.
CAS PubMed Web of Science® Google Scholar
Quackenbush FW, Miller SL. 1972. Composition and analysis of the carotenoids in marigold petals. J Assoc Anal Chem 55: 617–621.
CAS PubMed Web of Science® Google Scholar
Rodriguez E, Mabry TJ. 1977. Tagetes—chemical review. In The Biology and Chemistry of the Compositae, VH Heywood, BJ Harborne, BL Turner, (eds). Academic Press: London, New York, San Francisco, 792–802.
Google Scholar
Secoy DM, Smith AE. 1983. Use of plants in control of agricultural and domestic pests. Econ Bot 37: 28–57.
10.1007/BF02859304
Web of Science® Google Scholar
Tsurufuji S, Ohuchi K, Ishiguro M, Miura M. 1979. Inhibition of allergic foot pad inflammation by antirheumatic drug D-penicillamine. J Pharm Dyn 2: 187–191.
10.1248/bpb1978.2.187
CAS Web of Science® Google Scholar
Whittle BA. 1964. The use of changes in capillary in mice to distinguish between narcotic and non-narcotic analgesia. Br J Pharmacol 22: 246–252.
10.1111/j.1476-5381.1964.tb02030.x
CAS PubMed Web of Science® Google Scholar
Yasukawa K, Akihisa T, Kasahara Y et al., 1996. Inhibitory effect of alkane-6,8-diols, the components in safflower, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 53: 133–136.
10.1159/000227549
CAS PubMed Web of Science® Google Scholar
Yasukawa K, Akihisa T, Kasahara Y et al., 1998. Inhibitory effect of triterpenes from Compositae plants on tumor promotion in two-stage carcinogenesis in mouse skin. In Toward Natural Medicine Research in the 21st Century, H Ageta, N Aimi, Y Ebizuka, T Fujita, G Honda, (eds). Elsevier: Amsterdam, 207–218.
Web of Science® Google Scholar

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Volume16, Issue3

May 2002

Pages 217-222

Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model

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Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model

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