Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
Lingyi Lu
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorGeraldine Cancel-Tassin
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorAntoine Valeri
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorOlivier Cussenot
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorEthan M. Lange
University of Michigan ICPCG Group
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina
Search for more papers by this authorKathleen A. Cooney
University of Michigan ICPCG Group
Department of Medicine, University of Michigan, Ann Arbor, Michigan
Search for more papers by this authorJames M. Farnham
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorNicola J. Camp
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorLisa A. Cannon-Albright
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorTeuvo L.J. Tammela
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
Search for more papers by this authorJohanna Schleutker
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
Search for more papers by this authorJosef Hoegel
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Search for more papers by this authorKathleen Herkommer
University of Ulm ICPCG Group
Urologische Klinik, Universität Ulm, Ulm, Germany
Urologische Klinik rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
Search for more papers by this authorChristiane Maier
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Urologische Klinik, Universität Ulm, Ulm, Germany
Search for more papers by this authorWalther Vogel
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Search for more papers by this authorFredrik Wiklund
Karolinska Institute ICPCG Group
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorMonica Emanuelsson
Karolinska Institute ICPCG Group
Oncologic Centre, Umeå University, Umeå, Sweden
Search for more papers by this authorHenrik Grönberg
Karolinska Institute ICPCG Group
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorKathleen E. Wiley
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorSarah D. Isaacs
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorPatrick C. Walsh
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorBrian T. Helfand
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorDonghui Kan
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorWilliam J. Catalona
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorJanet L. Stanford
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorLiesel M. FitzGerald
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorBo Johanneson
FHCRC ICPCG Group
Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorKerry Deutsch
FHCRC ICPCG Group
Institute for Systems Biology, Seattle, Washington
Search for more papers by this authorLaura McIntosh
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorElaine A. Ostrander
FHCRC ICPCG Group
Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorStephen N. Thibodeau
Mayo Clinic ICPCG Group, Rochester, Minnesota
Search for more papers by this authorShannon K. McDonnell
Mayo Clinic ICPCG Group, Rochester, Minnesota
Search for more papers by this authorAlice S. Whittemore
BC/CA/HI ICPCG Group
Department of Health Research and Policy, Stanford School of Medicine, Stanford, California
Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California
Search for more papers by this authorIngrid Oakley-Girvan
BC/CA/HI ICPCG Group
Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California
Search for more papers by this authorChih-Lin Hsieh
BC/CA/HI ICPCG Group
Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California
Search for more papers by this authorIsaac Powell
African American Hereditary Prostate Cancer ICPCG Group
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
Search for more papers by this authorJoan E. Bailey-Wilson
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
African American Hereditary Prostate Cancer ICPCG Group
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorCheryl D. Cropp
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorClaire Simpson
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorJohn D. Carpten
African American Hereditary Prostate Cancer ICPCG Group
Genetic Basis of Human Disease Research Division, Translational Genomics Research Institute, Phoenix, Arizona
Search for more papers by this authorDaniela Seminara
National Cancer Institute, NIH, Bethesda, Maryland
Search for more papers by this authorS. Lilly Zheng
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorJianfen Xu
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorGraham G. Giles
ACTANE Consortium ICPCG Group
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Search for more papers by this authorGianluca Severi
ACTANE Consortium ICPCG Group
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Search for more papers by this authorJohn L. Hopper
ACTANE Consortium ICPCG Group
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Search for more papers by this authorDallas R. English
ACTANE Consortium ICPCG Group
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Search for more papers by this authorWilliam D. Foulkes
ACTANE Consortium ICPCG Group
Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada
Search for more papers by this authorLovise Maehle
ACTANE Consortium ICPCG Group
The Norwegian Radium Hospital, Oslo, Norway
Search for more papers by this authorPal Moller
ACTANE Consortium ICPCG Group
The Norwegian Radium Hospital, Oslo, Norway
Search for more papers by this authorMichael D. Badzioch
ACTANE Consortium ICPCG Group
Division of Medical Genetics, University of Washington Medical Center, Seattle, Washington
Search for more papers by this authorSteve Edwards
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorMichelle Guy
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorRos Eeles
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorDouglas Easton
ACTANE Consortium ICPCG Group
Cancer Research UK Genetic Epidemiology Unit, Cambridge, UK
Search for more papers by this authorCorresponding Author
William B. Isaacs
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Marburg 115, Johns Hopkins Hospital, Baltimore, MD 21287.Search for more papers by this authorInternational Consortium for Prostate Cancer Genetics
Search for more papers by this authorLingyi Lu
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorGeraldine Cancel-Tassin
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorAntoine Valeri
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorOlivier Cussenot
CeRePP ICPCG Group, Hopital Tenon, Assistance publique-Hopitaux de Paris, Paris, France
Search for more papers by this authorEthan M. Lange
University of Michigan ICPCG Group
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina
Search for more papers by this authorKathleen A. Cooney
University of Michigan ICPCG Group
Department of Medicine, University of Michigan, Ann Arbor, Michigan
Search for more papers by this authorJames M. Farnham
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorNicola J. Camp
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorLisa A. Cannon-Albright
University of Utah ICPCG Group, Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah
Search for more papers by this authorTeuvo L.J. Tammela
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
Search for more papers by this authorJohanna Schleutker
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
Search for more papers by this authorJosef Hoegel
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Search for more papers by this authorKathleen Herkommer
University of Ulm ICPCG Group
Urologische Klinik, Universität Ulm, Ulm, Germany
Urologische Klinik rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
Search for more papers by this authorChristiane Maier
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Urologische Klinik, Universität Ulm, Ulm, Germany
Search for more papers by this authorWalther Vogel
University of Ulm ICPCG Group
Institut fuer Humangenetik, Universität Ulm, Ulm, Germany
Search for more papers by this authorFredrik Wiklund
Karolinska Institute ICPCG Group
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorMonica Emanuelsson
Karolinska Institute ICPCG Group
Oncologic Centre, Umeå University, Umeå, Sweden
Search for more papers by this authorHenrik Grönberg
Karolinska Institute ICPCG Group
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Search for more papers by this authorKathleen E. Wiley
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorSarah D. Isaacs
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorPatrick C. Walsh
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Search for more papers by this authorBrian T. Helfand
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorDonghui Kan
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorWilliam J. Catalona
Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago, Illinois
Search for more papers by this authorJanet L. Stanford
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorLiesel M. FitzGerald
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorBo Johanneson
FHCRC ICPCG Group
Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorKerry Deutsch
FHCRC ICPCG Group
Institute for Systems Biology, Seattle, Washington
Search for more papers by this authorLaura McIntosh
FHCRC ICPCG Group
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington
Search for more papers by this authorElaine A. Ostrander
FHCRC ICPCG Group
Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorStephen N. Thibodeau
Mayo Clinic ICPCG Group, Rochester, Minnesota
Search for more papers by this authorShannon K. McDonnell
Mayo Clinic ICPCG Group, Rochester, Minnesota
Search for more papers by this authorAlice S. Whittemore
BC/CA/HI ICPCG Group
Department of Health Research and Policy, Stanford School of Medicine, Stanford, California
Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California
Search for more papers by this authorIngrid Oakley-Girvan
BC/CA/HI ICPCG Group
Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California
Search for more papers by this authorChih-Lin Hsieh
BC/CA/HI ICPCG Group
Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California
Search for more papers by this authorIsaac Powell
African American Hereditary Prostate Cancer ICPCG Group
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
Search for more papers by this authorJoan E. Bailey-Wilson
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
African American Hereditary Prostate Cancer ICPCG Group
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorCheryl D. Cropp
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorClaire Simpson
University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
National Human Genome Research Institute, NIH, Bethesda, Maryland
Search for more papers by this authorJohn D. Carpten
African American Hereditary Prostate Cancer ICPCG Group
Genetic Basis of Human Disease Research Division, Translational Genomics Research Institute, Phoenix, Arizona
Search for more papers by this authorDaniela Seminara
National Cancer Institute, NIH, Bethesda, Maryland
Search for more papers by this authorS. Lilly Zheng
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorJianfen Xu
Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Search for more papers by this authorGraham G. Giles
ACTANE Consortium ICPCG Group
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Search for more papers by this authorGianluca Severi
ACTANE Consortium ICPCG Group
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Search for more papers by this authorJohn L. Hopper
ACTANE Consortium ICPCG Group
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Search for more papers by this authorDallas R. English
ACTANE Consortium ICPCG Group
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Search for more papers by this authorWilliam D. Foulkes
ACTANE Consortium ICPCG Group
Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada
Search for more papers by this authorLovise Maehle
ACTANE Consortium ICPCG Group
The Norwegian Radium Hospital, Oslo, Norway
Search for more papers by this authorPal Moller
ACTANE Consortium ICPCG Group
The Norwegian Radium Hospital, Oslo, Norway
Search for more papers by this authorMichael D. Badzioch
ACTANE Consortium ICPCG Group
Division of Medical Genetics, University of Washington Medical Center, Seattle, Washington
Search for more papers by this authorSteve Edwards
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorMichelle Guy
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorRos Eeles
ACTANE Consortium ICPCG Group
Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK
Search for more papers by this authorDouglas Easton
ACTANE Consortium ICPCG Group
Cancer Research UK Genetic Epidemiology Unit, Cambridge, UK
Search for more papers by this authorCorresponding Author
William B. Isaacs
Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Marburg 115, Johns Hopkins Hospital, Baltimore, MD 21287.Search for more papers by this authorInternational Consortium for Prostate Cancer Genetics
Search for more papers by this authorAbstract
BACKGROUND
In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.
METHODS
In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups.
RESULTS
Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13–25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology.
CONCLUSIONS
These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer. Prostate 72:410–426, 2012. © 2011 Wiley Periodicals, Inc.
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