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Architecture of helix bundle membrane proteins: An analysis of cytochrome c oxidase from bovine mitochondria
Erik Wallin,
Tomitake Tsukihara,
Shinya Yoshikawa,
Gunnar Von Heijne,
Arne Elofsson,
Erik Wallin
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Search for more papers by this authorTomitake Tsukihara
Institute for Protein Research, Osaka University, 3-2 Yamada-oka, Suita 565, Japan
Search for more papers by this authorShinya Yoshikawa
Department of Life Science, Himeji Institute of Technology, Kamigohri Akoh, Hyogo 678-12, Japan
Search for more papers by this authorGunnar Von Heijne
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Search for more papers by this authorCorresponding Author
Arne Elofsson
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, SwedenSearch for more papers by this authorErik Wallin,
Tomitake Tsukihara,
Shinya Yoshikawa,
Gunnar Von Heijne,
Arne Elofsson,
Erik Wallin
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Search for more papers by this authorTomitake Tsukihara
Institute for Protein Research, Osaka University, 3-2 Yamada-oka, Suita 565, Japan
Search for more papers by this authorShinya Yoshikawa
Department of Life Science, Himeji Institute of Technology, Kamigohri Akoh, Hyogo 678-12, Japan
Search for more papers by this authorGunnar Von Heijne
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Search for more papers by this authorCorresponding Author
Arne Elofsson
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, Sweden
Department of Biochemistry, Stockholm University, S-106 91 Stockholm, SwedenSearch for more papers by this authorAbstract
We have analyzed the structure of mitochondrial cytochrome c oxidase in terms of general characteristics thought to be important for describing the architecture of helix bundle membrane proteins. Many aspects of the structure are similar to what has previously been found for the photosynthetic reaction center and bacteriorhodopsin. Our results lead to a considerably more precise general picture of membrane protein architecture than has hitherto been possible to obtain.
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