Front Cover: Integration of “Omics” Strategies for Biomarkers Discovery and for the Elucidation of Molecular Mechanisms Underlying Brugada Syndrome
Graphical Abstract
The main characteristics of BrS are the peculiar ECG pattern. The study suggests a cooperative activity of mutated genes, deregulated miRNAs and proteins in orchestrating transcriptional and post-translational events concurring in the development of the Brugada cardiac phenotype. The image summarizes the integration of “-omics” approaches (genomic, mirnomic and proteomic) in “codifying” the peculiar ECG pattern of Brugada syndrome. This is reported by Domenica Scumaci, Antonio Oliva, Antonio Concolino, Antonio Curcio, Claudia Vincenza Fiumara, Laura Tammè, Oscar Campuzano, Vincenzo L. Pascali, Monica Coll, Anna Iglesias, Paola Berne, Gavino Casu, Erika Olivo, Francesco Ausania, Pietrantonio Ricci, Ciro Indolfi, Josep Brugada, Ramon Brugada, Giovanni Cuda in article number 1800065.
