Synthese von cyanosubstiuierten Di- und Tetrahydropyridinen in DIMCARB (Dimethylamin–CO₂-Additionsverbindung)

Synthesis of Cyanosubstituted Di- and Tetrahydropyridines in DIMCARB (Dimethylamine–CO₂-Adduct)

A new selective method for base-catalyzed ring closure reaction of acetophenones (1a–I) with malononitrile in DIMCARB (dimethylamine–CO₂-addition-compound) as solvent of high dimethylamine concentration is reported, which allows effective syntheses of (1.2-dihydro-4-pyrid-6-yl)dicyanomethanides and 5-cyano-6-dicyanomehylene-1,2,3,6-tetrahydropyridines in good yields. The structure of the two new classes of compounds is proved by X-ray diffraction analysis.