“Cepacia syndrome” associated with Burkholderia cepacia (Genomovar I) infection in an adolescent with cystic fibrosis
Corresponding Author
Edward F. Nash MRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Consultant in Respiratory Medicine and Honorary Senior Clinical Lecturer, West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.Search for more papers by this authorAjit Thomas MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRichard Whitmill MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRifat Rashid MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorBethan Barker MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRosie J. Rayner FRCPCH
Department of Paediatrics, New Cross Hospital, Wednesfield Road, Wolverhampton, UK
Search for more papers by this authorJoanna L. Whitehouse FRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorDavid Honeybourne FRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorCorresponding Author
Edward F. Nash MRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Consultant in Respiratory Medicine and Honorary Senior Clinical Lecturer, West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.Search for more papers by this authorAjit Thomas MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRichard Whitmill MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRifat Rashid MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorBethan Barker MRCP (UK)
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorRosie J. Rayner FRCPCH
Department of Paediatrics, New Cross Hospital, Wednesfield Road, Wolverhampton, UK
Search for more papers by this authorJoanna L. Whitehouse FRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this authorDavid Honeybourne FRCP
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
Search for more papers by this author
REFERENCES
- 1Ederer GM, Malsen JM. Colonisation and infection with Pseudomonas cepacia. J Infect Dis 1972; 125: 613–618.
- 2Isles A, Maclusky I, Corey M, Gold R, Prober C, Fleming P, Levison H. Pseudomonas cepacia infection in cystic fibrosis: An emerging problem. J Pediatr 1984; 104: 206–210.
- 3Vandamme P, Holmes B, Vancanneyt M, Coenye T, Hoste B, Coopman R, Revets H, Lauwers S, Gillis M, Kersters K, Govan JR. Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. nov. Int J Syst Bacteriol 1997; 47: 1188–1200.
- 4Mahenthiralingam E, Baldwin A, Dowson CG. Burkholderia cepacia complex bacteria: Opportunistic pathogens with important natural biology. J Appl Microbiol 2008; 104: 1539–1551.
- 5Vanlaere E, Lipuma JJ, Baldwin A, Henry D, De Brandt E, Mahenthiralingam E, Speert D, Dowson C, Vandamme P. Burkholderia latens sp. nov. Burkholderia diffusa sp. nov. Burkholderia arboris sp. nov. Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov. novel species within the Burkholderia cepacia complex. Int J Syst Evol Microbiol 2008; 58: 1580–1590.
- 6Vanlaere E, Baldwin A, Gevers D, Henry D, De Brandt E, LiPuma JJ, Mahenthiralingam E, Speert DP, Dowson C, Vandamme P, Taxon K. A complex within the Burkholderia cepacia complex, comprises at least two novel species: Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol 2009; 59: 102–111.
- 7LiPuma J. Update on Burkholderia nomenclature and resistance. Clin Microbiol Lett 2007; 29: 65–69.
10.1016/j.clinmicnews.2007.04.003 Google Scholar
- 8Lewin LO, Byard PJ, Davis PB. Effect of Pseudomonas cepacia colonization on survival and pulmonary function of cystic fibrosis patients. J Clin Epidemiol 1990; 43: 125–131.
- 9Ledson MJ, Gallagher MJ, Jackson M, Hart CA, Walshaw MJ. Outcome of Burkholderia cepacia colonisation in an adult cystic fibrosis centre. Thorax 2002; 57: 142–145.
- 10Jones A, Dodd M, Govan J, Barcus V, Doherty CJ, Morris J, Webb AK. Burkholderia cenocepacia and Burkholderia multivorans: Influence on survival in cystic fibrosis. Thorax 2004; 59: 948–951.
- 11Chaparro C, Maurer J, Gutierrez C, Kraiden M, Chan C, Winton T, Keshavjee S, Scavuzzo M, Tullis E, Hutcheon M, Keston S. Infection with Burkholderia cepacia in cystic fibrosis: Outcome following lung transplantation. Am J Respir Crit Care Med 2001; 163: 43–48.
- 12Aris RM, Routh JC, LiPuma JJ, Heath DG, Gilligan PH. Lung transplantation for cystic fibrosis patients with Burkholderia cepacia complex. Survival linked to genomovar type. Am J Respir Crit Care Med 2001; 164: 2102–2106.
- 13Kahariadis G, Levy MH, Burns JL. Cepacia-like syndrome caused by Burkholderia multivorans. Can J Infect Dis 2003; 14: 123–125.
- 14Blackburn L, Brownlee K, Conway S, Denton M. ‘Cepacia syndrome’ with Burkholderia multivorans, 9 years after initial colonization. J Cyst Fibros 2004; 3: 133–134.
- 15Turton JF, Arif N, Hennessy D, Kauffmann ME, Pitt TL. Revised approach for identification of isolates within the Burkholderia cepacia complex and description of clinical isolates not assigned to any of the known genomovars. J Clin Microbiol 2007; 45: 3105–3108.