Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: The Canadian asthma primary prevention study
Kathy K. Lee MD
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Search for more papers by this authorCorresponding Author
Richard G. Hegele MD, FRCPC, PhD
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.Search for more papers by this authorJure Manfreda MD
Department of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorKatherine Wooldrage BSc
Department of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorAllan B. Becker MD, FRCPC
Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorAlexander C. Ferguson MB, FRCPC
Department of Pediatrics, Children's and Women's Health Centre of British Columbia, University of British Columbia, Vancouver, British Columbia, Canada
Search for more papers by this authorHelen Dimich-Ward PhD
Division of Respiratory Medicine, University of British Columbia, Vancouver Hospital, Vancouver, British Columbia, Canada
Search for more papers by this authorWade T.A. Watson MD, FRCPC
Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorMoira Chan-Yeung MB, FRCPC
Division of Respiratory Medicine, University of British Columbia, Vancouver Hospital, Vancouver, British Columbia, Canada
Search for more papers by this authorKathy K. Lee MD
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Search for more papers by this authorCorresponding Author
Richard G. Hegele MD, FRCPC, PhD
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.Search for more papers by this authorJure Manfreda MD
Department of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorKatherine Wooldrage BSc
Department of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorAllan B. Becker MD, FRCPC
Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorAlexander C. Ferguson MB, FRCPC
Department of Pediatrics, Children's and Women's Health Centre of British Columbia, University of British Columbia, Vancouver, British Columbia, Canada
Search for more papers by this authorHelen Dimich-Ward PhD
Division of Respiratory Medicine, University of British Columbia, Vancouver Hospital, Vancouver, British Columbia, Canada
Search for more papers by this authorWade T.A. Watson MD, FRCPC
Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Search for more papers by this authorMoira Chan-Yeung MB, FRCPC
Division of Respiratory Medicine, University of British Columbia, Vancouver Hospital, Vancouver, British Columbia, Canada
Search for more papers by this authorAbstract
The contribution of respiratory viral infections to the onset of asthma and atopy is controversial. In “high risk” children (n = 455) born into asthmatic/atopic families, we determined the relationship of exposures to common respiratory viruses and concomitant respiratory symptoms, and to subsequent possible asthma and atopy at ages 1 and 2 years. Frozen nasal specimens, obtained when children were 2 weeks, 4, 8, and 12 months old, underwent reverse transcription-polymerase chain reaction (RT-PCR) testing for parainfluenza virus (PIV), respiratory syncytial virus (RSV), and picornavirus (rhinovirus/enterovirus). Odds ratios of viral RT-PCR results to respiratory symptoms (“cold,” rhinitis, cough, wheezing) and to possible asthma or atopy at 1 and 2 years of age were calculated. Positive viral RT-PCR was associated with increased odds of “cold” and cough; PIV and picornavirus were associated with rhinitis, and RSV was associated with wheezing. PIV was associated with increased odds of atopy at 1 year of age in the control group; PIV and RSV were associated with possible asthma at 2 years of age. We conclude that in high-risk children, viral exposures documented by RT-PCR are associated with respiratory symptoms, and exposures to PIV and RSV during the first year of life are associated with the initial onset of possible asthma. Pediatr Pulmonol. 2007; 42:290–297. © 2007 Wiley-Liss, Inc.
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