Plasma-activated water from a dielectric barrier discharge plasma source for the selective treatment of cancer cells
P. S. Ganesh Subramanian
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorAditi Jain
Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorAnand M. Shivapuji
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorNagalingam R. Sundaresan
Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India
Cardiovascular and Muscle Research Laboratory, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorSrinivasaiah Dasappa
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorCorresponding Author
Lakshminarayana Rao
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Correspondence Lakshminarayana Rao, Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Email: [email protected]
Search for more papers by this authorP. S. Ganesh Subramanian
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorAditi Jain
Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorAnand M. Shivapuji
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorNagalingam R. Sundaresan
Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India
Cardiovascular and Muscle Research Laboratory, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorSrinivasaiah Dasappa
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Search for more papers by this authorCorresponding Author
Lakshminarayana Rao
Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka, India
Correspondence Lakshminarayana Rao, Centre for Sustainable Technologies, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Email: [email protected]
Search for more papers by this authorAbstract
In this study, cold plasma was used to prepare plasma-activated water (PAW) from a dielectric barrier discharge plasma source, with ambient air as the plasma-forming gas. The PAW prepared was characterized for its physicochemical parameters, some of which followed a strong linear correlation with activation time (ta). The effects of PAW addition on the cell viability of human breast cancer cells (MDA-MB-231) and healthy murine muscle-derived fibroblast cells were investigated using the MTT assay. The volume of PAW added and ta of PAW showed a significant impact. The PAW prepared was selective toward killing cancer cells at specific ta. PAW retains its potency against cancer cells after 14 days of refrigerated storage.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
Supporting Information
| Filename | Description |
|---|---|
| ppap201900260-sup-0001-Supplementary_Material.docx15.1 KB | Supporting information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Y. F. Li, T. Shimizu, J. L. Zimmermann, G. E. Morfill, Plasma. Process. Polym. 2012, 9, 585.
- 2P. Narayanappa, A. Singh, L. Rao, S. Dasappa, presented at Proc. ISPC 23, Montreal, Canada, 2017.
- 3J. Ananthanarasimhan, L. Rao, A. M. Shivapuji, S. Dasappa, Proc. ISPC, 24, Naples, Italy, 2019.
- 4N. Punith, R. Harsha, R. Lakshminarayana, M. Hemanath, M. S. Anand, S. Dasappa, Adv. Mater. Lett. 2019, 10, 700.
- 5H. Rao, P. Narayanappa, L. Rao, A. M. Shivapuji, S. Dasappa, presented at Proc. ISPC 2019, Naples, Italy, 24.
- 6S. Sukhani, N. Punith, R. Lakshminarayana, H. N. Chanakya, Adv. Mater. Lett. 2019, 10, 797.
10.5185/amlett.2019.0043 Google Scholar
- 7G. Fridman, G. Friedman, A. Gutsol, A. B. Shekhter, V. N. Vasilets, A. Fridman, Plasma. Process. Polym. 2008, 5, 503.
- 8P. S. G. Subramanian, R. Harsha, D. K. Manju, M. Hemanth, R. Lakshminarayana, M. S. Anand, S. Dasappa, Adv. Mater. Lett. 2019, 10, 919.
10.5185/amlett.2019.0041 Google Scholar
- 9Plasma Chemistry and Catalysis in Gases and Liquids (Eds: V. I. Parvulescu, M. Magureanu, P. Lukes), Wiley, Hoboken, NJ 2012.
- 10Y. Li, M. H. Kang, H. S. Uhm, G. J. Lee, E. H. Choi, I. Han, Sci. Rep. 2017, 7, 45781.
- 11H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, H. Kajiyama, H. Kano, F. Kikkawa, M. Hori, Plasma Med. 2011, 1, 265.
10.1615/PlasmaMed.2012006275 Google Scholar
- 12N. Georgescu, A. R. Lupu, IEEE Trans. Plasma Sci. 2010, 38, 1949.
- 13B. Gweon, M. Kim, D. Bee Kim, D. Kim, H. Kim, H. Jung, J. H. Shin, W. Choe, Appl. Phys. Lett. 2011, 99, 063701.
- 14M. Wang, B. Holmes, X. Cheng, W. Zhu, M. Keidar, L. G. Zhang, PLOS One 2013, 8, e73741.
- 15J. Y. Kim, S. O. Kim, Y. Wei, J. Li, Appl. Phys. Lett. 2010, 96, 203701.
- 16J. Y. Kim, J. Ballato, P. Foy, T. Hawkins, Y. Wei, J. Li, S. O. Kim, Biosens. Bioelectron. 2011, 28, 333.
- 17M. Keidar, R. Walk, A. Shashurin, P. Srinivasan, A. Sandler, S. Dasgupta, R. Ravi, R. Guerrero-Preston, B. Trink, Br. J. Cancer 2011, 105, 1295.
- 18R. Guerrero-Preston, T. Ogawa, M. Uemura, G. Shumulinsky, B. L. Valle, F. Pirini, R. Ravi, D. Sidransky, M. Keidar, B. Trink, Int. J. Mol. Med. 2014, 34, 941.
- 19M. Naciri, D. Dowling, M. Al-Rubeai, Plasm. Process. Polym. 2014, 11, 391.
- 20M. Vandamme, E. Robert, S. Lerondel, V. Sarron, D. Ries, S. Dozias, J. Sobilo, D. Gosset, C. Kieda, B. Legrain, J. M. Pouvesle, A. L. Pape, Int. J. Cancer 2012, 130, 2185.
- 21Reboux, Cancer, https://www.who.int/news-room/fact-sheets/detail/cancer (accessed: April 2019).
- 22IARC, Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018, https://www.iarc.fr/featured-news/latest-global-cancer-data-cancer-burden-rises-to-18-1-million-new-cases-and-9-6-million-cancer-deaths-in-2018/ (accessed: April 2019).
- 23J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, F. Bray, Int. J. Cancer 2015, 136, E359.
- 24IARC, Cancer fact sheets, http://gco.iarc.fr/today/fact-sheets-cancers (accessed: April 2019).
- 25A. S. Silva, R. A. Gatenby, Biol. Direct, 2010, 5, 25.
- 26S. Crawford, Front. Pharmacol. 2013, 4, 1.
- 27M. G. Kong, G. Kroesen, G. Morfill, T. Nosenko, T. Shimizu, J. V. Dijk, J. L. Zimmermann, New J. Phys. 2009, 11, 115012.
- 28F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Hori, F. Kikkawa, SpringerPlus 2014, 3, 398.
- 29H. J. Ahn, K. I. Kim, G. Kim, E. Moon, S. S. Yang, J. S. Lee, PLOS One 2011, 6, e28154.
- 30I. E. Kieft, D. Darios, A. J. M. Roks, E. Stoffels, IEEE Trans. Plasma Sci. 2005, 33, 771.
- 31F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, H. Kano, M. Hori, F. Kikkawa, PLOS One 2013, 8, 1.
- 32L. Partecke, K. Evert, J. Haugk, F. Doering, L. Normann, S. Diedrich, F. U. Weiss, M. Evert, N. O. Huebner, C. Guenther, C. D. Heidecke, A. Kramer, R. Bussiahn, K. D. Weltmann, O. Pati, C. Bender, W. Bernstroff, BMC Cancer 2012, 12, 473.
- 33F. Saadati, H. Mahdikia, H. A. Abbaszadeh, M. A. Abdollahifar, M. S. Khoramgah, B. Shokri, Sci. Rep. 2018, 8, 7689.
- 34A. Jain, V. Ravi, J. Muhamed, K. Chatterjee, N. R. Sundaresan, Int. J. Cardiol. 2017, 232, 160.
- 35B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter, Molecular Biology of the Cell, 4th ed., Garland Science, New York 2002.
- 36B. Adinolfi, M. Pellegrino, F. Baldini, Biomed. Pharmacother. 2015, 69, 228.
- 37P. Rivalland, K. Vié, L. Coiffard, Y. De Roeck-Holtzhauer, Pharm. Acta Helv. 1994, 69, 159.
- 38J. K. Lee, D. B. Kim, J. I. Kim, P. Y. Kim, Toxicol. In Vitro 2000, 14, 345.
- 39D. G. Spindola, A. Hinsberger, V. M. de, S. Antunes, L. F. G. Michelin, C. Bincoletto, C. R. Oliveira, Braz. J. Pharm. Sci. 2018, 54, 1.
- 40R. Matsumoto, S. Kazunori, N. Takunori, T. Hiromasa, M. Masaaki, K. Fumitaka, H. Masaru, H. Hiroyuki, Regener. Ther. 2016, 5, 55.
- 41C. Pan, C. Kumar, S. Bohl, U. Klingmueller, M. Mann, Mol. Cell. Proteomics 2009, 8, 443.
- 42 American Type Culture Collection Standards Development Organization Workgroup ASN-0002, Nat. Rev. Cancer 2010, 10, 441.
- 43T. Reya, H. Clevers, Nature 2005, 434, 843.
- 44D. Porter, M. D. Poplin, F. Holzer, W. C. Finney, B. R. Locke, IEEE Trans. Ind. Appl. 2009, 45, 623.
- 45R. Thirumdas, A. Kothakota, U. Annapure, K. Siliveru, R. Blundell, R. Gatt, V. P. Valdramidis, Trends Food Sci. Technol. 2018, 77, 21.
- 46I. E. Vlad, S. D. Anghel, J. Electrostat. 2017, 87, 284.
- 47R. Laurita, D. Barbieri, M. Gherardi, V. Colombo, P. Lukes, Clin. Plasma Med. 2015, 3, 53.
- 48P. Lu, D. Boehm, P. Bourke, P. J. Cullen, Plasma Processes Polym. 2017, 14, 1.
- 49H. S. Kim, K. C. Wright, I. W. Hwang, D. H. Lee, A. Rabinovich, A. Fridman, Y. I. Cho, Int. Commun. Heat Mass Transfer. 2013, 42, 5.
- 50W. F. L. M. Hoeben, P. P. van Ooij, D. C. Schram, T. Huiskamp, A. J. M. Pemen, P. Lukeš, Plasma Chem. Plasma Process. 2019, 39, 597.
- 51L. Sivachandiran, Khacef, RSC Adv. 2017, 7, 1822.
- 52J. Shen, Y. Tian, Y. Li, R. Ma, Q. Zhang, J. Zhang, J. Fang, Sci. Rep. 2016, 6.
- 53J. Chauvin, F. Judée, M. Yousfi, P. Vicendo, N. Merbahi, Sci. Rep. 2017, 7, 1.
- 54F. Judée, S. Simon, C. Bailly, T. Dufour, Water Res. 2017, 133, 47.
- 55Q. Xiang, C. Kang, L. Niu, D. Zhao, K. Li, Y. Bai, LWT 2018, 96, 395.
- 56I. F. Tannock, D. Rotin, Cancer Res. 1989, 49, 4373.
- 57N. Rosenthal, S. Brown, Nat. Cell Biol. 2007, 9, 993.
- 58C. Szpirer Rat Genomics. Methods in Molecular Biology (Methods and Protocols) (Ed: I. Anegon), Humana Press, Totowa, NJ 2010.
- 59D.-J. Cheon, S. Orsulic, Annu. Rev. Pathol.: Mech. Dis. 2011, 6, 95.
- 60A. S. Seluanov, A. Vaidya, V. Gorbunova, J. Vis. Exp. 2010.
- 61M. A. Chapman, R. Meza, R. L. Lieber, Differentiation 2016, 92, 108.
- 62S. Kalghatgi, G. Friedman, A. Fridman, A. M. Clyne, Ann. Biomed. Eng. 2010, 38, 748.
- 63M. Naítali, G. Kamgang-Youbi, J. M. Herry, M. N. Bellon-Fontaine, J. L. Brisset, Appl. Environ. Microbiol. 2010, 76, 7662.
- 64M. J. Traylor, M. J. Pavlovich, S. Karim, P. Hait, Y. Sakiyama, D. S. Clark, D. B. Graqves, J. Phys. D: Appl. Phys. 2011, 44, 3.
- 65P. Lukes, E. Dolezalova, I. Sisrova, M. Clupek, Plasma Sources Sci. Technol. 2014, 23, 1.
