Anti-Cancer Effects of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells in Human Endometrioid Adenocarcinoma Cells
Corresponding Author
Jun-Ichiro Ikeda
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorYoko Tsuruta
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorSatoshi Nojima
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorHajime Sakakita
Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba, 305-8568 Japan
Search for more papers by this authorMasaru Hori
Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku Nagoya, 464-8603 Japan
Search for more papers by this authorYuzuru Ikehara
Molecular Medicine Team, Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba, 305-8568 Japan
Search for more papers by this authorCorresponding Author
Jun-Ichiro Ikeda
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorYoko Tsuruta
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorSatoshi Nojima
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, 565-0871 Japan
Search for more papers by this authorHajime Sakakita
Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba, 305-8568 Japan
Search for more papers by this authorMasaru Hori
Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku Nagoya, 464-8603 Japan
Search for more papers by this authorYuzuru Ikehara
Molecular Medicine Team, Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba, 305-8568 Japan
Search for more papers by this authorAbstract
To examine the effect of NEAPP on cancer-initiating cells (CICs) that are believed to cause recurrence or metastasis due to their resistance to anti-cancer drugs, the treatment of nonequilibrium atmospheric pressure plasma (NEAPP) combined with anti-cancer drug cisplatin and NEAPP irradiation of tumor xenograft mice are performed in human uterine endometrioid adenocarcinoma cells. NEAPP treatment affects both ALDH-low (non-CICs) and ALDH-high cells (CICs) more efficiently than cisplatin. In tumor xenograft mice, ALDH expression reduces in tumor with NEAPP irradiation. These results suggest that NEAPP treatment is effective not only on non-CICs but also on CICs.
References
- 1 M. G. Kong, G. Kroesen, G. Morfill, T. Nosenko, T. Shimizu, J. van Dijk, J. L. Zimmermann, New J. Phys. 2009, 11, 115012.
- 2 S. Kalghatgi, C. M. Kelly, E. Cerchar, B. Torabi, O. Alekseev, A. Fridman, G. Friedman, J. Azizkhan-Clifford, PLoS ONE 2011, 6, e16270.
- 3
H. Sakakita,
Y. Ikehara,
Plasma Fusion Res.
2010,
5, S2117.
10.1585/pfr.5.S2117 Google Scholar
- 4 Y. Ikehara, H. Sakakita, N. Shimizu, S. Ikehara, H. Nakanishi, J. Photopolym. Sci. Technol. 2013, 26, 555.
- 5 G. Fridman, G. Friedman, A. Gutsol, A. B. Shekhter, V. N. Vasilets, A. Fridman, Plasma Process. Polym. 2008, 5, 1142.
- 6
H. Tanaka,
M. Mizuno,
K. Ishikawa,
K. Nakamura,
H. Kajiyama,
H. Kano,
F. Kikkawa,
M. Hori,
Plasma Med.
2011,
1, 265.
10.1615/PlasmaMed.2012006275 Google Scholar
- 7 S. Iseki, K. Nakamura, M. Hayashi, H. Tanaka, H. Kondo, H. Kajiyama, H. Kano, F. Kikkawa, M. Hori, Appl. Phys. Lett. 2012 100, 113702.
- 8 F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, H. Kano, M. Hori, F. Kikkawa, PLoS ONE 2013, 8, e81576.
- 9 C. H. Kim, J. H. Bahn, S. H. Lee, G. Y. Kim, S. I. Jun, K. Lee, S. J. Baek, J Biotechnol. 2010 150, 530.
- 10
S. Kalghatgi,
C. Kelly,
E. Cerchar,
J. Azizkhan-Clifford,
Plasma Med.
2011,
1, 249.
10.1615/PlasmaMed.2012004184 Google Scholar
- 11 A. R. Gibson, H. O. McCarthy, A. A. Ali, D. O'Connell, W. G. Graham, Plasma Process. Polym. 2014, 11, 1142.
- 12 D. Bonnet, J. E. Dick, Nat. Med. 1997, 3, 730.
- 13 M. Diehn, R. W. Cho, N. A. Lobo, T. Kalisky, M. J. Dorie, A. N. Kulp, D. Qian, J. S. Lam, L. E. Ailles, M. Wong, B. Joshua, M. J. Kaplan, I. Wapnir, F. M. Dirbas, G. Somlo, C. Garberoglio, B. Paz, J. Shen, S. K. Lau, S. R. Quake, J. M. Brown, I. L. Weissman, M. F. Clarke, Nature 2009, 458, 780.
- 14 J. Ikeda, S. Mamat, T. Tian, Y. Wang, W. Luo, N. Rahadiani, K. Aozasa, E. Morii, Lab. Invest. 2012, 92, 606.
- 15 T. Kondo, T. Setoguchi, T. Taga, Proc. Natl. Acad. Sci. USA. 2004, 101, 781.
- 16 C. A. O'Brien, A. Pollett, S. Gallinger, J. E. Dick, Nature 2007, 445, 106.
- 17 N. Rahadiani, J. Ikeda, S. Mamat, S. Matsuzaki, Y. Ueda, R. Umehara, T. Tian, Y. Wang, T. Enomoto, T. Kimura, K. Aozasa, E. Morii, Cancer Sci. 2011, 102, 903.
- 18 T. Reya, S. J. Morrison, M. F. Clarke, I. L. Weissman, Nature 2001, 414, 105.
- 19 L. Ricci-Vitiani, D. G. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro, C. Peschle, R. De Maria, Nature 2007, 445, 111.
- 20 C. Ginestier, M. H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C. G. Kleer, S. Liu, A. Schott, D. Hayes, D. Birnbaum, M. S. Wicha, G. Dontu, Cell Stem Cell 2007, 1, 555.
- 21 F. Jiang, Q. Qiu, A. Khanna, N. W. Todd, J. Deepak, L. Xing, H. Wang, Z. Liu, Y. Su, S. A. Stass, R. L. Katz, Mol. Cancer Res. 2009, 7, 330.
- 22 I. Ma, A. L. Allan, Stem Cell Rev. 2011, 7, 292.
- 23 J. P. Chute, G. G. Muramoto, J. Whitesides, M. Colvin, R. Safi, N. J. Chao, D. P. McDonnell, Proc. Natl. Acad. Sci. USA. 2006, 103, 11707.
- 24
J. Ikeda,
Plasma Med.
2014,
4, 49.
10.1615/PlasmaMed.2014011935 Google Scholar
- 25 L. Brulle, M. Vandamme, D. Ries, E. Martel, E. Robert, S. Lerondel, V. Trichet, S. Richard, J. M. Pouvesle, A. L. Pape, PLoS ONE 2012, 7, e52653.
Citing Literature
