Volume 28, Issue 12 pp. 2351-2357

PAPER

Health-related quality of life by human immunodeficiency virus status in a cross-sectional survey of gay and bisexual prostate cancer survivors

Elizabeth J. Polter,

Corresponding Author

Elizabeth J. Polter

[email protected]

orcid.org/0000-0001-7336-3492

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

Correspondence

Elizabeth Polter, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S. 2nd St, Ste 300, Minneapolis, MN 55454.

Email: [email protected]

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Christopher W. Wheldon,

Christopher W. Wheldon

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland

Department of Public Health, Temple University, Philadelphia, Pennsylvania

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B.R. Simon Rosser,

B.R. Simon Rosser

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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Nidhi Kohli,

Nidhi Kohli

Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota

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Benjamin D. Capistrant,

Benjamin D. Capistrant

orcid.org/0000-0001-5841-6592

School of Social Work, Smith College, Northampton, Massachusetts

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Aditya Kapoor,

Aditya Kapoor

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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Badrinath Konety,

Badrinath Konety

Department of Urology, University of Minnesota, Minneapolis, Minnesota

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Darryl Mitteldorf,

Darryl Mitteldorf

Malecare Cancer Support, 85 Delancey Street (The Yard), New York, New York

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Michael Ross,

Michael Ross

Department of Family Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota

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Kristine M.C. Talley,

Kristine M.C. Talley

School of Nursing, University of Minnesota, Minneapolis, Minnesota

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Loren Terveen,

Loren Terveen

Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota

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William West,

William West

Department of Writing Studies, University of Minnesota, Minneapolis, Minnesota

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Morgan M. Wright,

Morgan M. Wright

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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Elizabeth J. Polter,

Corresponding Author

Elizabeth J. Polter

[email protected]

orcid.org/0000-0001-7336-3492

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

Correspondence

Elizabeth Polter, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S. 2nd St, Ste 300, Minneapolis, MN 55454.

Email: [email protected]

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Christopher W. Wheldon,

Christopher W. Wheldon

Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland

Department of Public Health, Temple University, Philadelphia, Pennsylvania

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B.R. Simon Rosser,

B.R. Simon Rosser

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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Nidhi Kohli,

Nidhi Kohli

Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota

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Benjamin D. Capistrant,

Benjamin D. Capistrant

orcid.org/0000-0001-5841-6592

School of Social Work, Smith College, Northampton, Massachusetts

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Aditya Kapoor,

Aditya Kapoor

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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Badrinath Konety,

Badrinath Konety

Department of Urology, University of Minnesota, Minneapolis, Minnesota

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Darryl Mitteldorf,

Darryl Mitteldorf

Malecare Cancer Support, 85 Delancey Street (The Yard), New York, New York

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Michael Ross,

Michael Ross

Department of Family Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota

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Kristine M.C. Talley,

Kristine M.C. Talley

School of Nursing, University of Minnesota, Minneapolis, Minnesota

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Loren Terveen,

Loren Terveen

Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota

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William West,

William West

Department of Writing Studies, University of Minnesota, Minneapolis, Minnesota

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Morgan M. Wright,

Morgan M. Wright

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

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First published: 13 September 2019

https://doi.org/10.1002/pon.5228

Citations: 9

Funding information: National Cancer Institute, Grant/Award Numbers: 1 R21 CA182041, CA182041; American Cancer Society Institutional Research Grant

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Abstract

Objective

Prostate cancer is the most common invasive cancer in gay and bisexual men (GBM). Despite the unique sexual and urinary concerns of this group, studies of prostate cancer rehabilitation have primarily focused on heterosexual men. GBM also have high prevalence of human immunodeficiency virus (HIV), which may be associated with lower health-related quality of life (HRQOL). We examined the association between HIV status and HRQOL in a cohort of GBM with prostate cancer.

Methods

Data from the Restore study, a cross-sectional online survey of GBM treated for prostate cancer, were used to examine this association. The Expanded Prostate Cancer Index Composite (EPIC) assessed function, bother, and summary measures in four domains: urinary, sexual, bowel, and hormone. Overall physical and mental HRQOL was assessed using the Short-Form Health Survey (SF-12). Multivariate analysis of variance and linear regression were used to evaluate the association between HIV status and HRQOL scores after adjustment for demographic and sexual characteristics.

Results

Of 192 participants, 24 (12.4%) reported an HIV diagnosis. After adjustment for covariates, HIV-positive status was associated with lower scores on the EPIC urinary (mean difference [MD]: −13.0, 95% CI, −21.4 to −4.6), sexual (MD: −12.5, 95% CI, −21.9 to −3.2), and bowel (MD: −5.9, 95% CI, −11.7 to −0.2) domains. No significant associations were observed between HIV status and other outcomes.

Conclusions

HIV status may be associated with poorer urinary, sexual, and bowel HRQOL in GBM prostate cancer survivors.

CONFLICT OF INTEREST

The authors have no conflict of interest to report.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Citing Literature

Volume28, Issue12

December 2019

Pages 2351-2357

Health-related quality of life by human immunodeficiency virus status in a cross-sectional survey of gay and bisexual prostate cancer survivors

Abstract

Objective

Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

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Health-related quality of life by human immunodeficiency virus status in a cross-sectional survey of gay and bisexual prostate cancer survivors

Abstract

Objective

Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Related

Information