Acute Liver Failure in a 17-Year-Old Boy Caused by a Blastic Plasmacytoid Dendritic Cell Neoplasm With a Novel MYB Rearrangement
Atsushi Kohso
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorCorresponding Author
Hidemi Toyoda
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Correspondence: Hidemi Toyoda ([email protected])
Search for more papers by this authorMari Morimoto
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorKaori Niwa
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTakahiro Ito
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorRyo Hanaki
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTomonori Sakazaki
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorYosuke Okumura
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTakao Deguchi
Division of Cancer Immunodiagnostics, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYuji Shimokariya
Department of Clinical Laboratory, Mie University Hospital, Tsu, Japan
Search for more papers by this authorSatoru Muramatsu
Pathology Division, Mie University Hospital, Tsu, Japan
Search for more papers by this authorYoshifumi Hirokawa
Pathology Division, Mie University Hospital, Tsu, Japan
Search for more papers by this authorHideki Muramatsu
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
Search for more papers by this authorMasahiro Hirayama
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorAtsushi Kohso
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorCorresponding Author
Hidemi Toyoda
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Correspondence: Hidemi Toyoda ([email protected])
Search for more papers by this authorMari Morimoto
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorKaori Niwa
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTakahiro Ito
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorRyo Hanaki
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTomonori Sakazaki
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorYosuke Okumura
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorTakao Deguchi
Division of Cancer Immunodiagnostics, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYuji Shimokariya
Department of Clinical Laboratory, Mie University Hospital, Tsu, Japan
Search for more papers by this authorSatoru Muramatsu
Pathology Division, Mie University Hospital, Tsu, Japan
Search for more papers by this authorYoshifumi Hirokawa
Pathology Division, Mie University Hospital, Tsu, Japan
Search for more papers by this authorHideki Muramatsu
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
Search for more papers by this authorMasahiro Hirayama
Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
Search for more papers by this authorFunding: The authors received no specific funding for this work.

Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
References
- 1B. Cuglievan, J. Connors, J. He, et al., “Blastic Plasmacytoid Dendritic Cell Neoplasm: A Comprehensive Review in Pediatrics, Adolescents, and Young Adults (AYA) and an Update of Novel Therapies,” Leukemia 37 (2023): 1767–1778.
- 2T. Li, P. Wu, M. Chen, M. Fu, and H. Wang, “Blastic Plasmacytoid Dendritic Cell Neoplasm Presenting as Eyelid Mass Without Cutaneous Involvement in a Child,” Pediatric Blood & Cancer 70 (2023): e30433.
- 3H. J. Kosasih, G. Healey, M. S. Brennan, et al., “A Novel MYB::PAIP1 Oncogenic Fusion in Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Is Dependent on BCL2 Expression and Is Sensitive to Venetoclax,” HemaSphere 8 (2024): e1.
- 4K. Suzuki, Y. Suzuki, A. Hama, et al., “Recurrent MYB Rearrangement in Blastic Plasmacytoid Dendritic Cell Neoplasm,” Leukemia 31 (2017): 1629–1633.
- 5D. M. Reddi, A. S. Barbas, A. W. Castleberry, et al., “Liver Transplantation in an Adolescent With Acute Liver Failure From Acute Lymphoblastic Leukemia,” Pediatric Transplantation 18 (2014): E57–E63.
- 6R. L. Gu, M. Xiang, J. Suo, and J. Yuan, “Acute Lymphoblastic Leukemia in an Adolescent Presenting With Acute Hepatic Failure: A Case Report,” Molecular and Clinical Oncology 11 (2019): 135–138.
- 7J. B. Litten, M. M. Rodríguez, and V. Maniaci, “Acute Lymphoblastic Leukemia Presenting in Fulminant Hepatic Failure,” Pediatric Blood & Cancer 47 (2006): 842–845.