Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)
Corresponding Author
Wendy Hsiao
Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, California, USA
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Correspondence
Wendy Hsiao, Division of Nephrology, 4650 Sunset Blvd, MS #40, Los Angeles, CA 90027, USA.
Email: [email protected]
Search for more papers by this authorYimei Li
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorKelly Getz
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorLusha Cao
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorEdward Krause
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMark Ramos
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJudy Lee
Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA
Search for more papers by this authorMaria Monica Gramatges
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorKaren R. Rabin
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorMichael E. Scheurer
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorRichard Aplenc
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMichelle Denburg
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorTamara P. Miller
Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Search for more papers by this authorCorresponding Author
Wendy Hsiao
Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, California, USA
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Correspondence
Wendy Hsiao, Division of Nephrology, 4650 Sunset Blvd, MS #40, Los Angeles, CA 90027, USA.
Email: [email protected]
Search for more papers by this authorYimei Li
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorKelly Getz
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorLusha Cao
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorEdward Krause
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMark Ramos
Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJudy Lee
Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA
Search for more papers by this authorMaria Monica Gramatges
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorKaren R. Rabin
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorMichael E. Scheurer
Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA
Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Search for more papers by this authorRichard Aplenc
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorMichelle Denburg
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorTamara P. Miller
Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Search for more papers by this authorPreviously presented as: “Assessment of the spectrum of kidney injury during therapy for pediatric acute leukemia,” Pediatric Academic Societies 2023 Meeting; April 30, 2023; Washington, DC, USA (poster).
Abstract
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.
CONFLICT OF INTEREST STATEMENT
The authors declare they have no conflicts of interest.
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