Intrathecal tobramycin and pausing induction chemotherapy for pediatric acute lymphoblastic leukemia facilitate successful management of disseminated Pseudomonas aeruginosa infection and meningitis
Corresponding Author
Henri Aarnivala
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Correspondence
Henri Aarnivala, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland.
Email: [email protected]
Search for more papers by this authorTerhi Tapiainen
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this authorOuti Peltoniemi
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this authorRiitta Niinimäki
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this authorCorresponding Author
Henri Aarnivala
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Correspondence
Henri Aarnivala, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland.
Email: [email protected]
Search for more papers by this authorTerhi Tapiainen
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this authorOuti Peltoniemi
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this authorRiitta Niinimäki
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland
Search for more papers by this author
REFERENCES
- 1Toft N, Birgens H, Abrahamsson J, et al. Results of NOPHO ALL2008 treatment for patients aged 1–45 years with acute lymphoblastic leukemia. Leukemia. 2018; 32(3): 606–615.
- 2Lund B, Åsberg A, Heyman M, et al. Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer. 2011; 56(4): 551–559.
- 3Li S, Chen Y, Li Z, et al. Infections during induction therapy of protocol CCLG-2008 in childhood acute lymphoblastic leukemia: a single-center experience with 256 cases in China. Chin Med J (Engl). 2015; 128(4): 472–476.
- 4O'Connor D, Bate J, Wade R, et al. Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003. Blood. 2014; 124(7): 1056–1061.
- 5Bodey GP, Jadeja L, Elting L. Pseudomonas bacteremia: retrospective analysis of 410 episodes. Arch Intern Med. 1985; 145(9): 1621–1629.
- 6Maurice NM, Bedi B, Sadikot RT. Pseudomonas aeruginosa biofilms: host response and clinical implications in lung infections. Am J Respir Cell Mol Biol. 2018; 58(4): 428–439.
- 7Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009; 22(4): 582–610.
- 8Nau R, Blei C, Eiffert H. Intrathecal antibacterial and antifungal therapies. Clin Microbiol Rev. 2020; 33(3): e00190-19.
- 9Tunkel AR, Hasbun R, Bhimraj A, et al. 2017 Infectious Diseases Society of America's clinical practice guidelines for healthcare-associated ventriculitis and meningitis. Clin Infect Dis. 2017; 64(6): e34–e65.
- 10Bhardwaj NK, Khera D, Gupta N, Singh K. Disseminated Pseudomonas aeruginosa sepsis as presenting diagnosis of X-linked agammaglobulinaemia in a previously well 16-month-old child. BMJ Case Rep. 2017; 2017:bcr2017221006.
10.1136/bcr-2017-221006 Google Scholar
- 11Kaiser AB, McGee ZA. Aminoglycoside therapy of gram-negative bacillary meningitis. N Engl J Med. 1975; 293(24): 1215–1220.
- 12Karvouniaris M, Brotis AG, Tsiamalou P, Fountas KN. The role of intraventricular antibiotics in the treatment of nosocomial ventriculitis/meningitis from gram-negative pathogens: a systematic review and meta-analysis. World Neurosurg. 2018; 120: e637–e650.
- 13LeBras M, Chow I, Mabasa VH, Ensom MHH. Systematic review of efficacy, pharmacokinetics, and administration of intraventricular aminoglycosides in adults. Neurocrit Care. 2016; 25(3): 492–507.
- 14Graubner UB, Porzig S, Jorch N, et al. Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008; 50(2): 259–263.