Volume 64, Issue 2 pp. 311-314

Brief Report

IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Lei Chen,

Lei Chen

Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Lika'a Fasih Y. Al-Kzayer,

Lika'a Fasih Y. Al-Kzayer

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Tingting Liu,

Corresponding Author

Tingting Liu

[email protected]

Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence

Tingting Liu, Department of Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China.

Email: [email protected]

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Norimoto Kobayashi,

Norimoto Kobayashi

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Yozo Nakazawa,

Yozo Nakazawa

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Kenichi Koike,

Kenichi Koike

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Lei Chen,

Lei Chen

Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Lika'a Fasih Y. Al-Kzayer,

Lika'a Fasih Y. Al-Kzayer

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Tingting Liu,

Corresponding Author

Tingting Liu

[email protected]

Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence

Tingting Liu, Department of Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China.

Email: [email protected]

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Norimoto Kobayashi,

Norimoto Kobayashi

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Yozo Nakazawa,

Yozo Nakazawa

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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Kenichi Koike,

Kenichi Koike

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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First published: 12 September 2016

https://doi.org/10.1002/pbc.26236

Citations: 16

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Abstract

IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.

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Citing Literature

Volume64, Issue2

February 2017

Pages 311-314

Filename	Description
pbc26236-sup-0001-text.TIF1 MB	SUPPLEMENTARY FIGURE S1 B-cell marker of CD20 positively expressed in neoplastic cells
pbc26236-sup-0002-text.TIF1.6 MB	SUPPLEMENTARY FIGURE S2 T-cell markers of CD3 and CD43 negatively expressed in neoplastic cells
pbc26236-sup-0003-text.TIF1.9 MB	SUPPLEMENTARY FIGURE S3 Follicular dendritic cells positive for CD21 and CD23

IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

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IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

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